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  4. MAFF Antibody

MAFF Antibody

  • 中文名稱：
    MAFF兔多克隆抗體
  • 貨號：
    CSB-PA425800
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA425800(MAFF Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA425800(MAFF Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    MAFF
  • 別名：
    Avian musculoaponeurotic fibrosarcoma virus (v maf) AS42 oncogene, protein F antibody; CTA 447C4.1 antibody; hMafF antibody; MAFF antibody; MAFF_HUMAN antibody; OTTHUMP00000199299 antibody; Transcription factor MafF antibody; U MAF antibody; U-Maf antibody; V maf avian musculoaponeurotic fibrosarcoma oncogene family, protein F antibody; V maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) antibody; V maf musculoaponeurotic fibrosarcoma oncogene homolog F antibody; V-maf musculoaponeurotic fibrosarcoma oncogene homolog F antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human MAFF
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition.
  • 基因功能參考文獻：
    1. MAF genes have different levels of biological and genetic relevance. Besides, MAFF and MAFG could be associated with the susceptibility to develop CML. PMID: 24118457
    2. MafF/NFE2 hetrodimers act as weak transcriptional activators, and, in particular, are able to stimulate activity of the GCS1 promoter. PMID: 12490281
    3. In myometrial cells we observed an important induction by interleukin 1 beta and a weaker upregulation by tumor necrosis factor, whereas interleukin 6 treatment had no effect. PMID: 16371591
    4. Expression of hMafF or MIP alone did not alter basal reporter transcription activity, whereas co-expression of hMafF and MIP activated transcription efficiently. PMID: 16549056
    5. Only in the presence of both MIP and hMafF could the nUS2-pLacZi reporter in yeast genome be activated. PMID: 19723544

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family, Maf subfamily
  • 組織特異性：
    Expressed in the term myometrium and kidney.
  • 數據庫鏈接：

    HGNC: 6780

    OMIM: 604877

    KEGG: hsa:23764

    STRING: 9606.ENSP00000345393

    UniGene: Hs.517617



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