在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MADCAM1 Antibody, FITC conjugated

MADCAM1 Antibody, FITC conjugated

  • 中文名稱：
    MADCAM1兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA618776HC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MADCAM1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Addressin mucosal antibody; hMAdCAM 1 antibody; hMAdCAM-1 antibody; MACAM1 antibody; MADCA_HUMAN antibody; MAdCAM 1 antibody; MAdCAM-1 antibody; Madcam1 antibody; Mucosal addressin cell adhesion molecule 1 antibody; Mucosal vascular addressin cell adhesion molecule 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Mucosal addressin cell adhesion molecule 1 protein (19-317AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
  • 基因功能參考文獻(xiàn)：
    1. Both the ACT-1 assay and the MAdCAM-1 assay demonstrated acceptable reproducibility and repeatability. The assays were sufficiently stable to allow for clinical use. During clinical testing the assays demonstrated that vedolizumab was able to saturate peripheral cells at all doses tested. PMID: 25908521
    2. Doxo-induced apoptosis has a role in inhibiting hepatocellular carcinoma by targeting Madcam1 and AKT and blocking protein translation initiation PMID: 26124182
    3. MADCAM1 is up-regulated in liver cirrhosis with expression on peribiliary vascular plexus and lymphoid aggregates PMID: 23839340
    4. Domain 1 of mucosal addressin cell adhesion molecule has an I1-set fold and a flexible integrin-binding loop. PMID: 23297416
    5. Findings suggest that the inactive alpha4beta7 and alpha4beta7 activated by different stimuli have distinct conformations with different structural requirements for MAdCAM-1 binding. PMID: 21296888
    6. Ca2+ is essential for cell tethering in flow and rolling interactions through alpha 4 integrins with MAdCAM-1 as substrate; Mg2+ promotes firm adhesion of cells on MAdCAM-1 but with much lower tethering efficiency in shear flow. PMID: 11705388
    7. A crystal structure for the two extracellular amino-terminal domains of human MAdCAM-1 PMID: 11807247
    8. more extensive expression of MAdCAM-1 in Crohn's disease (CrD), than in ulcerative colitis, which could contribute not only to mucosal inflammation, but also to transmural inflammation in CrD. PMID: 12100519
    9. MAdCAM-1/integrin alpha4beta7 homing system may participate in gastric inflammation in response to H pylori-infection and contributes to MALT formation, typically leading to the development of nodular gastritis. PMID: 14669317
    10. a marker of graft rejection in small intestine transplantation PMID: 15050155
    11. PI3-K/Akt is involved in the gut-specific differentiation of human intestinal microvascular endothelial cells, which results in expression of the mucosal addressin MAdCAM-1 PMID: 15483224
    12. Immobilized CCL25 and CCL28 are both able to trigger integrin alpha(4)beta(7)-dependent lymphocyte arrest on MAdCAM-1 under shear flow. PMID: 18308860
    13. mucosal addressin cell adhesion molecule 1 may represent an important determinant for the generation of mucosal damage in celiac disease PMID: 19157500
    14. MADCAM1 gene polymorphisms may be associated with the risk of chronic GVHD and may, also, affect mortality related to aHSCT. PMID: 19286444

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ov
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6765

    OMIM: 102670

    KEGG: hsa:8174

    STRING: 9606.ENSP00000215637

    UniGene: Hs.102598



主站蜘蛛池模板： 亚洲综合无码精品一区二区三区| 在线观看片免费人成视频无码| 亚洲人成人无码www影院| 又粗又大内射免费视频小说| 国产性夜夜春夜夜爽1a片| 日韩欧国产精品一区综合无码| 伊人色综合久久天天网| 一边摸一边叫床一边爽av| 国产精品无码久久久久久| 伊人久久精品一区二区三区| 亚洲精品亚洲人成在线| 无码人妻精品丰满熟妇区| 国精产品蘑菇一区一区有限| 综合亚洲另类欧美久久成人精品| 全黄性性激高免费视频| 亚洲中文无码人a∨在线导航| 国产成人亚洲综合青青| 伊人久久久大香线蕉综合直播| 国产精品美女久久久久久久久| 日韩精品无码一区二区中文字幕| 久久三级中文欧大战字幕| 色夜码无码av网站| 色综合久久一区二区三区| 红桃av一区二区三区在线无码av| 免费看美女部位隐私网站| 国内精品伊人久久久久av影院 | 国产白嫩美女在线观看| 九九综合九色综合网站| 人妻无码少妇一区二区| 亚洲国产精久久久久久久| 天堂а√在线中文在线| 久久精品国产首页027007| 亚洲人成电影网站在线播放| 国产伦精品一区二区三区妓女| 欧美老妇与zozozo交| 99精品热在线在线观看视频| 国产成人av 综合 亚洲| 国产精品无码免费播放| 人妻少妇久久中文字幕456| 久久―日本道色综合久久| 国产a∨精品一区二区三区不卡|