在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MACF1 Antibody

MACF1 Antibody

  • 中文名稱：
    MACF1兔多克隆抗體
  • 貨號：
    CSB-PA890946LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA890946LA01HU diluted at 1:400 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MACF1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    MACF1 antibody; ABP620 antibody; ACF7 antibody; KIAA0465 antibody; KIAA1251 antibody; Microtubule-actin cross-linking factor 1 antibody; isoforms 1/2/3/5 antibody; 620 kDa actin-binding protein antibody; ABP620 antibody; Actin cross-linking family protein 7 antibody; Macrophin-1 antibody; Trabeculin-alpha antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 protein (1936-2150AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，MACF1 Antibody (CSB-PA890946LA01HU)，的標記方式是Non-conjugated。對于MACF1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA890946LB01HU MACF1 Antibody, HRP conjugated ELISA
    FITC CSB-PA890946LC01HU MACF1 Antibody, FITC conjugated
    Biotin CSB-PA890946LD01HU MACF1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells. As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development.
  • 基因功能參考文獻：
    1. Loss of ACF7 leads to aberrant microtubule organization, tight junction stabilization and impaired wound closure in vitro. ACF7 level is also correlated with development and progression of ulcerative colitis (UC) in patients. PMID: 28541346
    2. Study summarized the physiological role of MACF1 as well as its pathological one in various cancers. MACF1 comprises different isoforms, and is broadly expressed in brain, spinal cord, lung, kidney, heart, bone and skeletal muscles tissues. It plays a crucial role in cell proliferation, migration and cell signaling, and is also closely associated with many cancer. PMID: 28782898
    3. in mammalian intestinal epithelial cells, the spectraplakin ACF7 (also known as MACF1) specifically binds to CAMSAP3 and is required for the apical localization of CAMSAP3-decorated microtubule minus ends. PMID: 27802168
    4. MACF1b may contribute to the genetic etiology and mechanistic causation of Parkinson's disease. PMID: 27021023
    5. ACF7, a member of the spectraplakin family of cytoskeletal crosslinking proteins, interacts with Nezha (also called CAMSAP3) at the minus ends of noncentrosomal microtubules and anchors them to actin filaments. PMID: 27693509
    6. the present study represents the first investigation on the functional role of MACF1 in tumor cell biology, as well as demonstrates its potential as a unique biomarker that can be targeted synergistically with TMZ as part of a combinatorial therapeutic approach for the treatment of genetically multifarious glioblastomas PMID: 27959385
    7. Duplication in the microtubule-actin cross-linking factor 1 gene causes neuromuscular diseases. PMID: 24899269
    8. uncovered a role for ELMO in the recruitment of ACF7 to the membrane to promote microtubule capture and stability PMID: 23184944
    9. ACF7 targeting to the plasma membrane is both required and sufficient for microtubule capture downstream of ErbB2. PMID: 20937854
    10. p230, through its interaction with MACF1, provides the molecular link for transport of GPI-anchored proteins along the microtubule and actin cytoskeleton from the TGN to the cell periphery. PMID: 15265687
    11. In two lung cell lines, MACF1b was chiefly localized to the Golgi complex. The domain of MACF1b that targets it to the Golgi was found at the N-terminal part of the region that contains the plakin repeats. PMID: 16076900

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform 2]: Cytoplasm, cytoskeleton. Cytoplasm. Golgi apparatus. Cell membrane. Cell projection, ruffle membrane.; [Isoform 1]: Cytoplasm. Golgi apparatus.
  • 蛋白家族：
    Plakin or cytolinker family
  • 組織特異性：
    Isoform 2: Ubiquitously expressed. Isoform 1: Expressed in cell lines NCI-H460, A-549 and HaCaT. Isoform 4: Expressed in heart, lung, pituitary and placenta, not found in brain, kidney, liver, pancreas or skeletal muscle.
  • 數據庫鏈接：

    HGNC: 13664

    OMIM: 608271

    KEGG: hsa:23499

    STRING: 9606.ENSP00000354573

    UniGene: Hs.472475



主站蜘蛛池模板： 成人片无码免费播放| 亚洲成a人片77777kkkk| 丝袜人妻一区二区三区| 学生精品国产在线视频| 国产7色在线 | 国产| 97婷婷狠狠成为人免费视频| 67194熟妇在线观看线路1| 国产午夜精品无码| 国产亚洲产品影视在线产品| 少妇呻吟白浆高潮啪啪69| 天堂а√8在线最新版在线| 国产精品自在欧美一区| 免费无码a片一区二三区| 亚洲国产老鸭窝一区二区三区| 亚洲精品成人网站在线观看| 99久久精品国产一区二区蜜芽| 亚洲熟妇中文字幕日产无码| 亚洲日韩va在线视频| 久久无码高潮喷水| 男人靠女人免费视频网站| 亚洲欧美日韩中文无线码| 午夜免费啪视频在线18| 国产性生大片免费观看性| 成人片黄网站色大片免费毛片| 成人性生交大片免费看96| 琪琪秋霞午夜av影视在线| 99热成人精品热久久| 国产精品网站在线观看免费传媒| 日日噜噜夜夜狠狠久久蜜桃| 国产免费午夜福利不卡片在线| 露脸内射熟女--69xx| 欧美激情一区二区三区在线| 久久 国产 尿 小便 嘘嘘| 国内精品久久久久电影院| 亚洲色欲综合一区二区三区| 久久婷婷激情综合色综合俺也去 | 四虎影库久免费视频| 中文国产成人精品久久不卡 | 免费无码专区在线视频| 波多野结衣在线观看一码| 小雪好紧好滑好湿好爽视频|