在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MACF1 Antibody

MACF1 Antibody

  • 中文名稱：
    MACF1兔多克隆抗體
  • 貨號：
    CSB-PA890946LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA890946LA01HU diluted at 1:400 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MACF1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    MACF1 antibody; ABP620 antibody; ACF7 antibody; KIAA0465 antibody; KIAA1251 antibody; Microtubule-actin cross-linking factor 1 antibody; isoforms 1/2/3/5 antibody; 620 kDa actin-binding protein antibody; ABP620 antibody; Actin cross-linking family protein 7 antibody; Macrophin-1 antibody; Trabeculin-alpha antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 protein (1936-2150AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，MACF1 Antibody (CSB-PA890946LA01HU)，的標記方式是Non-conjugated。對于MACF1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA890946LB01HU MACF1 Antibody, HRP conjugated ELISA
    FITC CSB-PA890946LC01HU MACF1 Antibody, FITC conjugated
    Biotin CSB-PA890946LD01HU MACF1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells. As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development.
  • 基因功能參考文獻：
    1. Loss of ACF7 leads to aberrant microtubule organization, tight junction stabilization and impaired wound closure in vitro. ACF7 level is also correlated with development and progression of ulcerative colitis (UC) in patients. PMID: 28541346
    2. Study summarized the physiological role of MACF1 as well as its pathological one in various cancers. MACF1 comprises different isoforms, and is broadly expressed in brain, spinal cord, lung, kidney, heart, bone and skeletal muscles tissues. It plays a crucial role in cell proliferation, migration and cell signaling, and is also closely associated with many cancer. PMID: 28782898
    3. in mammalian intestinal epithelial cells, the spectraplakin ACF7 (also known as MACF1) specifically binds to CAMSAP3 and is required for the apical localization of CAMSAP3-decorated microtubule minus ends. PMID: 27802168
    4. MACF1b may contribute to the genetic etiology and mechanistic causation of Parkinson's disease. PMID: 27021023
    5. ACF7, a member of the spectraplakin family of cytoskeletal crosslinking proteins, interacts with Nezha (also called CAMSAP3) at the minus ends of noncentrosomal microtubules and anchors them to actin filaments. PMID: 27693509
    6. the present study represents the first investigation on the functional role of MACF1 in tumor cell biology, as well as demonstrates its potential as a unique biomarker that can be targeted synergistically with TMZ as part of a combinatorial therapeutic approach for the treatment of genetically multifarious glioblastomas PMID: 27959385
    7. Duplication in the microtubule-actin cross-linking factor 1 gene causes neuromuscular diseases. PMID: 24899269
    8. uncovered a role for ELMO in the recruitment of ACF7 to the membrane to promote microtubule capture and stability PMID: 23184944
    9. ACF7 targeting to the plasma membrane is both required and sufficient for microtubule capture downstream of ErbB2. PMID: 20937854
    10. p230, through its interaction with MACF1, provides the molecular link for transport of GPI-anchored proteins along the microtubule and actin cytoskeleton from the TGN to the cell periphery. PMID: 15265687
    11. In two lung cell lines, MACF1b was chiefly localized to the Golgi complex. The domain of MACF1b that targets it to the Golgi was found at the N-terminal part of the region that contains the plakin repeats. PMID: 16076900

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform 2]: Cytoplasm, cytoskeleton. Cytoplasm. Golgi apparatus. Cell membrane. Cell projection, ruffle membrane.; [Isoform 1]: Cytoplasm. Golgi apparatus.
  • 蛋白家族：
    Plakin or cytolinker family
  • 組織特異性：
    Isoform 2: Ubiquitously expressed. Isoform 1: Expressed in cell lines NCI-H460, A-549 and HaCaT. Isoform 4: Expressed in heart, lung, pituitary and placenta, not found in brain, kidney, liver, pancreas or skeletal muscle.
  • 數據庫鏈接：

    HGNC: 13664

    OMIM: 608271

    KEGG: hsa:23499

    STRING: 9606.ENSP00000354573

    UniGene: Hs.472475



主站蜘蛛池模板： 一本大道久久东京热av| 久久丫精品国产| 久久综合久久美利坚合众国| 亚洲国内精品自在线影院| 久久大香线蕉国产精品免费| 男女啪啪进出阳道猛进| 艳z门照片无码av| 韩国午夜福利片在线观看| 成人免费无码不卡毛片| 日韩成人大屁股内射喷水| 天天干天天射天天操| 三上悠亚精品一区二区久久 | 亚洲午夜无码久久久久 | 被技师按摩到高潮的少妇| 99热在线精品免费全部my| 久久精品国产导航| 国产av激情久久无码天堂| 亚洲孰妇无码av在线播放| 国产精品 欧美 亚洲 制服 | 亚洲精品456在线播放 | 99视频精品全部免费免费观看| 久久久一本精品99久久精品66直播 | 亚洲最大的成人网站| 成熟女人特级毛片www免费| 国产精品无码嫩草地址更新| 无码国产69精品久久久久孕妇| 国产亚洲日韩在线播放更多| 国内精品乱码卡一卡2卡| 久久国产精品久久久久久| 中文字幕亚洲日韩无线码| 久久综合久久88中字幕文| 欧美丰满熟妇多毛xxxxx| 欧美丰满熟妇xxxx性大屁股| 欧洲性久久精品| 波多野无码黑人在线播放| 国产欧美一区二区三区免费视频 | 视频在线+欧美十亚洲曰本| 国产美女露脸口爆吞精| 日日夜夜撸啊撸| 热久久美女精品天天吊色| 国产精品星空无限传媒|