在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MACF1 Antibody

MACF1 Antibody

  • 中文名稱：
    MACF1兔多克隆抗體
  • 貨號：
    CSB-PA890946LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA890946LA01HU diluted at 1:400 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MACF1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    MACF1 antibody; ABP620 antibody; ACF7 antibody; KIAA0465 antibody; KIAA1251 antibody; Microtubule-actin cross-linking factor 1 antibody; isoforms 1/2/3/5 antibody; 620 kDa actin-binding protein antibody; ABP620 antibody; Actin cross-linking family protein 7 antibody; Macrophin-1 antibody; Trabeculin-alpha antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 protein (1936-2150AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，MACF1 Antibody (CSB-PA890946LA01HU)，的標記方式是Non-conjugated。對于MACF1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA890946LB01HU MACF1 Antibody, HRP conjugated ELISA
    FITC CSB-PA890946LC01HU MACF1 Antibody, FITC conjugated
    Biotin CSB-PA890946LD01HU MACF1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells. As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development.
  • 基因功能參考文獻：
    1. Loss of ACF7 leads to aberrant microtubule organization, tight junction stabilization and impaired wound closure in vitro. ACF7 level is also correlated with development and progression of ulcerative colitis (UC) in patients. PMID: 28541346
    2. Study summarized the physiological role of MACF1 as well as its pathological one in various cancers. MACF1 comprises different isoforms, and is broadly expressed in brain, spinal cord, lung, kidney, heart, bone and skeletal muscles tissues. It plays a crucial role in cell proliferation, migration and cell signaling, and is also closely associated with many cancer. PMID: 28782898
    3. in mammalian intestinal epithelial cells, the spectraplakin ACF7 (also known as MACF1) specifically binds to CAMSAP3 and is required for the apical localization of CAMSAP3-decorated microtubule minus ends. PMID: 27802168
    4. MACF1b may contribute to the genetic etiology and mechanistic causation of Parkinson's disease. PMID: 27021023
    5. ACF7, a member of the spectraplakin family of cytoskeletal crosslinking proteins, interacts with Nezha (also called CAMSAP3) at the minus ends of noncentrosomal microtubules and anchors them to actin filaments. PMID: 27693509
    6. the present study represents the first investigation on the functional role of MACF1 in tumor cell biology, as well as demonstrates its potential as a unique biomarker that can be targeted synergistically with TMZ as part of a combinatorial therapeutic approach for the treatment of genetically multifarious glioblastomas PMID: 27959385
    7. Duplication in the microtubule-actin cross-linking factor 1 gene causes neuromuscular diseases. PMID: 24899269
    8. uncovered a role for ELMO in the recruitment of ACF7 to the membrane to promote microtubule capture and stability PMID: 23184944
    9. ACF7 targeting to the plasma membrane is both required and sufficient for microtubule capture downstream of ErbB2. PMID: 20937854
    10. p230, through its interaction with MACF1, provides the molecular link for transport of GPI-anchored proteins along the microtubule and actin cytoskeleton from the TGN to the cell periphery. PMID: 15265687
    11. In two lung cell lines, MACF1b was chiefly localized to the Golgi complex. The domain of MACF1b that targets it to the Golgi was found at the N-terminal part of the region that contains the plakin repeats. PMID: 16076900

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform 2]: Cytoplasm, cytoskeleton. Cytoplasm. Golgi apparatus. Cell membrane. Cell projection, ruffle membrane.; [Isoform 1]: Cytoplasm. Golgi apparatus.
  • 蛋白家族：
    Plakin or cytolinker family
  • 組織特異性：
    Isoform 2: Ubiquitously expressed. Isoform 1: Expressed in cell lines NCI-H460, A-549 and HaCaT. Isoform 4: Expressed in heart, lung, pituitary and placenta, not found in brain, kidney, liver, pancreas or skeletal muscle.
  • 數據庫鏈接：

    HGNC: 13664

    OMIM: 608271

    KEGG: hsa:23499

    STRING: 9606.ENSP00000354573

    UniGene: Hs.472475



主站蜘蛛池模板： 久久人人妻人人做人人爽| 亚洲欧美偷拍另类a∨| 色婷婷亚洲精品综合影院| 顶级少妇做爰视频在线观看 | 日韩高清国产一区在线| 最新精品国偷自产在线美女足 | 麻豆文化传媒精品一区观看| 日韩人妻无码免费视频一二区 | a毛片免费全部播放| 亚洲色欲色欲大片www无码| 少妇做爰免费视频了| 四虎永久在线精品无码视频| 日韩av无码精品一二三区| 精品一品国产午夜福利视频| 无码国产玉足脚交极品播放| 成人内射国产免费观看| 国产喷水1区2区3区咪咪爱av| 在线观看潮喷失禁大喷水无码| 亚洲人成77777在线播放网站不卡 国产 | 欧洲野花视频天堂视频p 亚洲aⅴ天堂av天堂无码 | 最新国产麻豆aⅴ精品无码| 欧亚乱熟女一区二区在线 | 西西人体大胆午夜啪啪| 亚洲 另类 在线 欧美 制服| 亚洲天堂在线观看完整版| 国产综合久久亚洲综合| 伊人色综合一区二区三区| 国产真实伦对白全集| 丁香五月综合久久激情| 吃奶呻吟打开双腿做受视频| 久久精品国产精品亚洲色婷婷| 在线看片免费人成视频福利 | 日产a一a区二区www| 亚洲国产区男人本色| 8天堂资源在线| 小荡货奶真大水多好紧视频| 性按摩无码中文| 色综合久久网| 国产福利视频一区二区| 色综合天天无码网站| 亚洲精品无码少妇30p| 免费中文熟妇在线影片|