在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. M6PR Antibody

M6PR Antibody

  • 中文名稱：
    M6PR兔多克隆抗體
  • 貨號：
    CSB-PA02625A0Rb
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA02625A0Rb at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA02625A0Rb at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA02625A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) M6PR Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    M6PR
  • 別名：
    M6PR; MPR46; MPRD; Cation-dependent mannose-6-phosphate receptor; CD Man-6-P receptor; CD-MPR; 46 kDa mannose 6-phosphate receptor; MPR 46
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Cation-dependent mannose-6-phosphate receptor protein (1-277AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，M6PR Antibody (CSB-PA02625A0Rb)，的標記方式是Non-conjugated。對于M6PR Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA02625B0Rb M6PR Antibody, HRP conjugated ELISA
    FITC CSB-PA02625C0Rb M6PR Antibody, FITC conjugated
    Biotin CSB-PA02625D0Rb M6PR Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
  • 基因功能參考文獻：
    1. Most rotavirus strains require the cation-independent mannose-6-phosphate receptor, sortilin-1, and cathepsins to enter cells. PMID: 29275103
    2. In light of existing report suggesting critical role of Nef-GCC185 interaction reveals valuable mechanistic insights affecting specific protein transport pathway in docking of late endosome derived Rab9 bearing transport vesicle at TGN elucidating role of Nef during viral pathogenesis. PMID: 27105913
    3. Results suggest that Rab protein Rab29 is essential for the integrity of the trans-Golgi network (TGN) and participates in the retrograde trafficking of mannose-6-phosphate receptor (M6PR). PMID: 24788816
    4. These data indicate that clathrin is required for the function of AP-1- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane. PMID: 24407285
    5. Sortilin is a new alpha-Gal A receptor expressed in renal endothelial cells and that this receptor together with the M6PR is able to internalize circulating alpha-Gal A. PMID: 22768187
    6. Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody PMID: 22163010
    7. mediates in vitro human immunodeficiency virus and sperm cell interaction PMID: 22015004
    8. sorting of the CD-MPR in late endosomes requires a distinct di-aromatic motif with only limited possibilities for variations PMID: 12697764
    9. All 5 MPRci-deficient lines resisted infection by cell-free, but not cell-associated, VZV, secreted lysosomal enzymes, and released infectious virions when infected by cell-associated VZV PMID: 15620351
    10. We conclude that the CI-MPR participates in lysosomal and granular targeting of serglycin and basic proteins such as lysozyme associated with the proteoglycan in hematopoietic cells. PMID: 17210618
    11. sortilin and mannose-6-phosphate receptors recycle to the TGN in SNX1-dependent carriers, which we named endosome-to-TGN transport carriers PMID: 18088323
    12. Missorting of cathepsin D in GARP-depleted cells results from accumulation of recycling MPRs in a population of light, small vesicles downstream of endosomes. PMID: 18367545
    13. Data demonstrate that Rab31 is required for transport of mannose 6-phosphate receptors from the trans-Golgi network to endosomes and for the Golgi/TGN organization. PMID: 19345684

    顯示更多

    收起更多

  • 亞細胞定位：
    Lysosome membrane; Single-pass type I membrane protein.
  • 數據庫鏈接：

    HGNC: 6752

    OMIM: 154540

    KEGG: hsa:4074

    STRING: 9606.ENSP00000000412

    UniGene: Hs.134084



主站蜘蛛池模板： 四库影院永久国产精品地址 | 大屁股熟女一区二区三区| 一本大道伊人av久久乱码| 无码一区二区三区在线观看| 两个美女裸体舌吻互扒内裤| 久久国内精品自在自线图片| 亚洲丁香婷婷久久一区二区| xx性欧美肥妇精品久久久久久| 久章草国语自产拍在线观看| 国产97色在线 | 日| 日本免费一区二区三区| 国产精品久久人妻无码网站一区| 2021国产精品一卡2卡三卡4卡| 国产av亚洲精品ai换脸电影 | 狠狠人妻久久久久久综合蜜桃| 国产影片中文字幕| 国产成人毛片在线视频软件| 成人免费精品网站在线观看影片| 丁香啪啪综合成人亚洲| 日韩av高清无码| 国内精品乱码卡一卡2卡三卡新区 亚洲爆乳成av人在线视菜奈实 | 99精品国产一区二区三区| 西西444www大胆无码视频 | 无码国产69精品久久久久网站| 国产精品成人一区二区三区 | 天堂а√在线中文在线最新版| 久久久精品国产sm最大网站| 亚洲国产99精品国自产拍| 婷婷色综合视频在线观看| 夜夜高潮夜夜爽夜夜爱爱| 999国内精品永久免费视频| 亚洲国产午夜精华无码福利| 东京热人妻丝袜无码av一二三区观| 成人网站在线进入爽爽爽| 国产精品高潮呻吟av久久4虎| 亚洲国产精品成人综合色| 玩弄丰满少妇xxxxx性多毛| 欧美老熟妇乱大交xxxxx| 香蕉久久av一区二区三区app| 亚洲成av人片天堂网无码】| a一区二区三区乱码在线 | 欧洲|