在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. Loxl2 Antibody

Loxl2 Antibody

  • 中文名稱：
    Loxl2兔多克隆抗體
  • 貨號：
    CSB-PA013041LA01MO
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: Loxl2 antibody at 14µg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: A549 whole cell lysate
      Lane 3: A431 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 88, 82 kDa
      Observed band size: 88 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Mus musculus (Mouse) Loxl2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Loxl2Lysyl oxidase homolog 2 antibody; EC 1.4.3.13 antibody; Lysyl oxidase-like protein 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Mouse, Human
  • 免疫原：
    Recombinant Mouse Lysyl oxidase homolog 2 protein (26-776AA)
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，Loxl2 Antibody (CSB-PA013041LA01MO)，的標記方式是Non-conjugated。對于Loxl2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA013041LB01MO Loxl2 Antibody, HRP conjugated ELISA
    FITC CSB-PA013041LC01MO Loxl2 Antibody, FITC conjugated
    Biotin CSB-PA013041LD01MO Loxl2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription. LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. During EMT, involved with SNAI1 in negatively regulating pericentromeric heterochromatin transcription. SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits. Interacts with the endoplasmic reticulum protein HSPA5 which activates the IRE1-XBP1 pathway of the unfolded protein response, leading to expression of several transcription factors involved in EMT and subsequent EMT induction. When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.
  • 基因功能參考文獻：
    1. although Loxl2 is expressed in both dermis and epidermis, its function appears largely confined to the epidermis. PMID: 29953488
    2. LOXL2 controls myofibroblast transformation and migration. PMID: 27966531
    3. The mRNA and protein expression levels of LOXL2 were higher in a mouse model of tubulointerstitial fibrosis compared with in control mice. PMID: 28677767
    4. Findings indicate a pathophysiologic role and function for lysyl oxidase-like protein LOXL2 in breast cancer metastasis. PMID: 28720577
    5. Insulin resistance promotes lysyl oxidase like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease. PMID: 28468951
    6. glomerular extracellular matrix. Altogether, we demonstrate that LOXL2 is a novel component of the molecular machinery that forms cross-linked collagen IV networks, which are essential for glomerular basement membrane stability and molecular ultrafiltration function. PMID: 27770022
    7. LOX and LOXL2 may play an important role in the pathogenesis of AMD. Targeting LOXL2 could have a broader efficacy than targeting LOX, by reducing angiogenesis and inflammation, as well as fibrosis. PMID: 26258612
    8. Loss and gain of function analyses combined with in vivo studies in syngeneic breast cancer models demonstrate the participation of LOXL2 and E47 in tumor growth and their requirement for lung metastasis. PMID: 24632622
    9. promoted intrahepatic metastasis by increasing tissue stiffness PMID: 25048396
    10. Findings reveal new insight into the mechanisms of fibroblast activation, a novel function of LOXL2, and further highlight the importance of generating LOXL2-targeted therapies for the prevention of tumor progression and metastasis. PMID: 24008674
    11. The Snail1 transcription factor represses mouse pericentromeric transcription, acting through the H3K4 deaminase LOXL2. PMID: 24239292
    12. The enzymatic activity of lysyl oxidas-like-2 (LOXL2) is not required for LOXL2-induced inhibition of keratinocyte differentiation. PMID: 22157764
    13. This study provides the first evidence for the role of LOXL2 in regulating angiogenesis through collagen IV scaffolding. PMID: 21835952
    14. LOXL2 promotes chondrocyte differentiation by mechanisms that are likely to include roles as both a regulator and an effector of chondrocyte differentiation PMID: 21071451
    15. The efficacy and safety of LOXL2-specific monoclonal antibody represents a new therapeutic approach with broad applicability in oncologic and fibrotic diseases. PMID: 20818376
    16. LoxL2 is not expressed in MC3T3-E1 cells. PMID: 15652501

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus. Chromosome. Endoplasmic reticulum.
  • 蛋白家族：
    Lysyl oxidase family
  • 組織特異性：
    Ubiquitous. Highest expression in skin, lung and thymus. Present in chondrocytes: mainly expressed by chondrocytes in healing fractures and in epiphyseal growth plates (at protein level).
  • 數據庫鏈接：


主站蜘蛛池模板： 久久精品国产福利一区二区| 精品久久香蕉国产线看观看亚洲| 欧美激情性做爰免费视频| 鲁丝片一区二区三区毛片| 亚洲国产欧美在线看片一国产| 国产精品偷伦视频观看免费| 少妇性l交大片欧洲热妇乱xxx| 亚洲精品第一国产综合亚av| 日产日韩亚洲欧美综合在线| 777米奇色狠狠俺去啦| 曰本无码人妻丰满熟妇啪啪| 国产午夜伦鲁鲁| 国产高清乱码又大又圆| 久久综合九色综合欧洲98| 秋霞影院午夜伦a片欧美| 欧美性xxxx极品少妇| 亚洲成av人片在线观看天堂无 | 成年无码a√片在线观看| 韩国乱码伦视频免费| 久久九九精品99国产精品 | 国产农村乱子伦精品视频| 欧美精品在线观看| 国产精品亚洲专区无码牛牛| 亚洲高清成人aⅴ片| 国产无遮挡a片又黄又爽漫画| 精品国产第一国产综合精品| 亚洲精品一区二区三区婷婷月| 国产成人精品久久一区二区| 激情航班h版在线观看| 精品乱码一区内射人妻无码| 医院人妻闷声隔着帘子被中出| 人妻少妇久久精品电影| 97人妻天天摸天天爽天天| 怡红院免费的全部视频| 欧美成人免费va影院高清| 麻花传媒mv国产免费观看视频| 国产国语老龄妇女a片| 国产日产欧产精品精品推荐免费| 欧美 日本 国产 在线a∨观看| 国产精品国产三级国产专区53| 性xxxxx大片免费视频|