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  4. LYAR Antibody

LYAR Antibody

  • 中文名稱：
    LYAR兔多克隆抗體
  • 貨號：
    CSB-PA003178
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of SH-SY5Y cells using LYAR Polyclonal Antibody
    • Western Blot analysis of HELA Jurkat cells using LYAR Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    LYAR
  • 別名：
    Cell growth regulating nucleolar protein antibody; Cell growth-regulating nucleolar protein antibody; Likely ortholog of mouse Ly1 antibody reactive clone antibody; Ly1 antibody reactive antibody; Ly1 antibody reactive homolog (mouse) antibody; Ly1 antibody reactive homolog antibody; LYAR antibody; LYAR_HUMAN antibody; ZC2HC2 antibody; ZLYAR antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human LYAR.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs. Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression. In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA. Preferentially binds to a DNA motif containing 5'-GGTTAT-3'. Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity. In addition, inhibits NF-kappa-B-mediated expression of proinflammatory cytokines. Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells. Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal.
  • 基因功能參考文獻：
    1. Data suggest that LYAR induces proliferation and promotes survival of neuroblastoma cells by repressing the expression of oxidative stress genes such as CHAC1 and suppressing oxidative stress, and identify LYAR as a novel co-factor in N-Myc oncogenesis. PMID: 28686580
    2. LYAR may promote tumor cell migration and invasion by upregulating galectin-1 gene expression in colorectal cancer. PMID: 26413750
    3. Results show that LYAR protein expression is testis-predominant but can also be found in cancer cells originated from tissues other than testis. Lyar seems to promote proliferation of NIH-3T3 cells. PMID: 24990247
    4. The data indicate that LYAR acts as a novel transcription factor that binds the gamma-globin gene, and is essential for silencing the gamma-globin gene. PMID: 25092918
    5. Over-expression of LYAR increases cell proliferation without affecting the expression of c-Myc or p53. Some rapidly growing cells enhance ribosome biogenesis by increasing the expression of LYAR. PMID: 24495227

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  • 亞細胞定位：
    Nucleus. Nucleus, nucleolus. Cytoplasm. Cell projection, cilium, photoreceptor outer segment.
  • 組織特異性：
    Predominantly expressed in testis.
  • 數據庫鏈接：

    HGNC: 26021

    OMIM: 617684

    KEGG: hsa:55646

    STRING: 9606.ENSP00000345917

    UniGene: Hs.425427



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