在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LTBP4 Antibody, FITC conjugated

  • 中文名稱:
    LTBP4兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào):
    CSB-PA02049C0Rb
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) LTBP4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    latent transforming growth factor beta binding protein 4 antibody; latent transforming growth factor beta binding protein 4L antibody; Latent-transforming growth factor beta-binding protein 4 antibody; LTBP 4 antibody; LTBP-4 antibody; LTBP4 antibody; LTBP4_HUMAN antibody; LTBP4L antibody; LTBP4S antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Latent-transforming growth factor beta-binding protein 4 protein (977-1180AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta.
  • 基因功能參考文獻(xiàn):
    1. DMD gene mutations involving the hinge 3 region, actin-binding domain, and exons 45-49, as well as the LTBP4 IAAM haplotype, were not associated with age of left ventricular dysfunction onset inDuchenne muscular dystrophy. PMID: 29766838
    2. High LTBP4 expression is associated with recurrence in glioblastoma. PMID: 27270107
    3. Studied the potential role of LTBP-4 in scleroderma through clinical, in vivo and in vitro studies. Results suggest that LTBP-4 protein level is increased in plasma and skin tissue of scleroderma patients; found LTBP-4 to be a potential biomarker to differentiate systemic scleroderma (SSc) from localized scleroderma (LSc) patients. PMID: 28263294
    4. The LTBP4 VTTT allele is associated with increased risk of dilated cardiomyopathy in European Americans. LTBP4 protein with the IAAM residues bound more latent TGFbeta compared to the LTBP4 VTTT protein. PMID: 26918958
    5. Our results show that LTBP4 interacts with TGFBR2 and stabilizes TGFbeta receptors by preventing their endocytosis and lysosomal degradation in a ligand-dependent and receptor kinase activity-dependent manner. PMID: 25882708
    6. We show that corticosteroid treatment and the IAAM haplotype of the LTBP4 gene are significantly associated with prolonged ambulation in patients with Duchenne muscular dystrophy PMID: 25476005
    7. In the mdx mouse model of Duchenne muscular dystrophy, the human LTBP4 transgene exacerbated muscular dystrophy symptoms and resulted in weaker muscles with an increased inflammatory infiltrate. PMID: 25338755
    8. In Caucasians with Duchenne muscular dystrophy and LTBP4 genotype there was a protective effect on age at loss of ambulation. PMID: 25641372
    9. It recruits elastin to microfibrils via fibulin-5. PMID: 25675815
    10. LTBP4 haplotype influences age at loss of ambulation, and should be considered in the management of Duchenne muscular dystrophy patients. PMID: 23440719
    11. Latent transforming growth factor beta-binding protein 4 is downregulated in esophageal cancer via promoter methylation. PMID: 23741501
    12. Data indicate mutations of FBLN4, FBLN5, and LTBP4 in 12 probands presenting with type 1 recessive cutis laxa. PMID: 22829427
    13. the G1 and G3 domains of versican were upregulated and LTBP-4 was downregulated in breast cancer stroma PMID: 21505857
    14. The lack of LTBP4-mediated targeting in malignant mammary tumor tissues may lead to a possible modification of TGF-ss1 and BMP bioavailability and function. PMID: 21468687
    15. Meta-analysis of abdominal aortic aneurysm size and growth rates demonstrated a significant association with the LTBP4 21011A>T genotype (a 2% decrease in AAA diameter, or a 0.53 mm/year reduction in AAA growth rate, per T allele [p=0.03, p=0.01]). PMID: 19897194
    16. These data suggest that LTBP-4 functions are modified by tissue-specific expression of the two N-terminally distinct variants, which in addition exhibit significant differences in cellular processing and targeting. PMID: 20175115
    17. Extracellular matrix is an important site of deposition for LTBP-3 and LTBP-4. PMID: 16157329
    18. Our findings suggest that variations in or near the HPN and LTBP4 genes do not play a role in the susceptibility to IA in the Dutch population. PMID: 18487557
    19. Novel functions for LTBP-4 as an adhesion molecule. PMID: 18585707
    20. Mutations in LTBP4 cause a syndrome of impaired pulmonary, gastrointestinal, genitourinary, musculoskeletal, and dermal development. PMID: 19836010

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Urban-Rifkin-Davis syndrome (URDS); Duchenne muscular dystrophy (DMD)
  • 亞細(xì)胞定位:
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族:
    LTBP family
  • 組織特異性:
    Highly expressed in heart, skeletal muscle, pancreas, uterus, and small intestine. Weakly expressed in placenta and lung.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6717

    OMIM: 310200

    KEGG: hsa:8425

    STRING: 9606.ENSP00000311905

    UniGene: Hs.466766



主站蜘蛛池模板: 含紧一点h边做边走动免费视频| 骚片av蜜桃精品一区| 欧美精品亚洲精品日韩专区va| 国产95在线 | 欧美| 怡春院久久国语视频免费| 午夜福制92视频| 亚洲天天做日日做天天欢毛片| 国产人妻大战黑人20p| 色一情一乱一伦| 亚洲在线国产日韩欧美| 怡春院久久国语视频免费| 亚洲五月综合缴情在线观看| 亚洲最大成人av在线天堂网 | 狠狠躁夜夜躁人人爽蜜桃| 日本欧美一区二区三区在线播放| 亚洲精品aa片在线观看国产| 久久精品国产99久久6| 粗了大了 整进去好爽视频| 日韩人妻无码制服丝袜视频| 亚洲日本在线在线看片| 很黄很黄的曰批视频| 高潮喷水的毛片| 亚洲鲁丝片一区二区三区| 亚洲欧美日韩中文加勒比| 精品国产第一福利网站| 欧美天天综合色影久久精品| 国产成人精品亚洲日本在线观看| 欧美变态另类牲交zozo| 强伦姧人妻免费无码电影| 亚洲欧美日韩综合久久久久久| 成人精品视频99在线观看免费| 欧美破苞系列二十三| 午夜好爽好舒服免费视频| 精品露脸国产偷人在视频| 97人妻天天摸天天爽天天| 在线观看无码不卡av| 国产精品 自在自线| 亚洲精品综合欧美一区二区| 中文字幕乱码熟女人妻水蜜桃| 国产精品久久久久久久| 久久99青青精品免费观看|