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  4. LRRFIP2 Antibody, HRP conjugated

LRRFIP2 Antibody, HRP conjugated

  • 中文名稱：
    LRRFIP2兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA896921LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) LRRFIP2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    LRRFIP2
  • 別名：
    5133400F20Rik antibody; AI850587 antibody; DKFZp434H2035 antibody; FLJ20248 antibody; FLJ22683 antibody; FLJ58304 antibody; HUFI 2 antibody; Leucine rich repeat (in FLII) interacting protein 2 antibody; Leucine rich repeat flightless interacting protein 2 antibody; Leucine-rich repeat flightless-interacting protein 2 antibody; LRR FLII interacting protein 2 antibody; LRR FLII-interacting protein 2 antibody; LRRF2_HUMAN antibody; Lrrfip2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Leucine-rich repeat flightless-interacting protein 2 protein (211-342AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
  • 基因功能參考文獻：
    1. Data show that the ability of Ca(2+) to accentuate the activity of NLRP3 inflammasome is abrogated in Flightless-I (FliI) and leucine-rich repeat FliI-interaction protein 2 (LRRFIP2)-knockdown macrophages. PMID: 27431477
    2. FATylation of LRRFIP2 occurs on two distinct sites, each being modified by a single FAT10 moiety. PMID: 23036196
    3. A novel exonic rearrangement affecting MLH1 and the contiguous LRRFIP2 is a founder mutation in Portuguese Lynch syndrome families PMID: 21785361
    4. Unambiguous characterization of site-specific phosphorylation of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in Toll-like receptor 4 (TLR4)-mediated signaling. PMID: 21220426
    5. These data suggest that LRRFIP2 plays an important role in transducing Wnt signals. PMID: 15677333
    6. LRR-binding MyD88 interactor LRRFIP2 is a positive regulator of NF-kappa B activity and is also a positive regulator of cytokine production in lipopolysaccharide-stimulated macrophages, suggesting a functional role in TLR4-mediated inflammatory response. PMID: 19265123

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  • 蛋白家族：
    LRRFIP family
  • 組織特異性：
    Widely expressed, with highest levels in heart and skeletal muscle.
  • 數據庫鏈接：

    HGNC: 6703

    OMIM: 614043

    KEGG: hsa:9209

    STRING: 9606.ENSP00000338727

    UniGene: Hs.740522



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