在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LPXN Antibody

  • 中文名稱:
    LPXN兔多克隆抗體
  • 貨號:
    CSB-PA013068GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    LPXN
  • 別名:
    LPXN antibody; LDLPLeupaxin antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human LPXN
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.
  • 基因功能參考文獻:
    1. LPXN may facilitate bladder cancer progression by upregulating the expression of S100P via PI3K/AKT pathway. These results provide a novel insight into the role of LPXN in tumorigenesis and progression of bladder cancer and potential therapeutic target of bladder cancer. PMID: 29975926
    2. this is the first demonstration of a role for the leupaxin in the regulation of hepatocellular carcinoma progression, at least in part, by enhancing beta-catenin transcription activity. PMID: 26361959
    3. The full-length leupaxin binds to the Pyk2-focal adhesion targeting domain. PMID: 26866573
    4. Authors demonstrate that LPXN directly influences cytoskeletal dynamics via interaction with the actin-binding protein CaD and regulates CaD phosphorylation by recruiting ERK to highly dynamic structures within PCa cells. PMID: 26079947
    5. Results show that leupaxin has particular influence on the progression and invasion of breast cancer cells and may therefore represent an interesting candidate protein for diagnosis and therapeutic interventions. PMID: 25955236
    6. first evidence of dynamic regulation of leupaxin localization and tyrosine phosphorylation by G-Protein Coupled Receptors PMID: 20543562
    7. leupaxin functions as a paxillin counterpart that potently suppresses the tyrosine phosphorylation of paxillin during integrin signaling. PMID: 19917054
    8. leupaxin may be a critical nucleating component of the osteoclast podosomal signaling complex PMID: 12674328
    9. Leupaxin binding to tyrosine phosphatase PEP suggests that leupaxin may function as a signal-transducing complex with PEP. PMID: 15786712
    10. These data demonstrate that LPXN forms a signaling complex with Pyk2, c-Src, and PTP-PEST to regulate migration of prostate cancer cells. PMID: 17329398
    11. Leupaxin plays an inhibitory role in BCR signaling and B cell function. PMID: 17640867
    12. leupaxin could serve as a potential progression marker for a subset of PCa and may represent a novel coactivator of the androgen receptor PMID: 18451096
    13. Leupaxin is enriched in vascular smooth nuscle. It undergoes cytoplasmic/nuclear shuttling & functions as an serum response factor cofactor. It associates with CArG-containing regions. Its ectopic expression induces smooth muscle marker gene expression. PMID: 18497331
    14. LPXN, a member of the paxillin superfamily, is fused to RUNX1 in an acute myeloid leukemia patient with a t(11;21)(q12;q22) translocation. PMID: 19760607

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region. Cell projection, podosome. Cell membrane. Note=Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B-cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin.
  • 蛋白家族:
    Paxillin family
  • 組織特異性:
    Macrophages, monocytes and osteoclasts (at protein level). Strongly expressed in cells and tissues of hematopoietic origin. Highest expression in lymphoid tissues such as spleen, lymph node, thymus and appendix and in the vascular smooth muscle. Lower lev
  • 數據庫鏈接:

    HGNC: 14061

    OMIM: 605390

    KEGG: hsa:9404

    STRING: 9606.ENSP00000431284

    UniGene: Hs.125474



主站蜘蛛池模板: 久九九久视频精品免费| 成人做爰视频www网站小优视频| 在线观看日本亚洲一区| 精品久久久久久久久久中文字幕| 另类 专区 欧美 制服| 18禁无遮挡羞羞污污污污免费| 日韩欧美国产aⅴ另类| 精品国产第一国产综合精品| 精品国产一区av天美传媒| 久久精品天天中文字幕人妻| 成在人线av无码免观看麻豆| 精品国内自产拍在线观看| 色无码av在线播放| 婷婷四房播播| 国产农村乱人伦精品视频| 国产sm精品调教视频网址 | 中文在线√天堂| 麻豆蜜桃av蜜臀av色欲av| 欧美大香线蕉线伊人久久| 免费做a爰片久久毛片a片| 无码国产乱人伦偷精品视频| 久久亚洲精品成人无码网站夜色| 8x国产精品视频| 欧美老熟妇xb水多毛多| 久久久亚洲欧洲日产国码αv| 在线看片免费人成视频国产片 | 亚洲国产av导航第一福利网| 国产偷窥熟女精品视频| 一 级做人爱全视频在线看| 黄页网站在线观看免费视频| 久久综合给久久狠狠97色| 思思99热久久精品在线6 | 不卡av电影在线| 亚洲熟妇无码av另类vr影视| 精品成人毛片一区二区| 野外做受三级视频| 国产猛男猛女超爽免费视频| 国产95在线 | 欧美| 中文字幕 欧美精品 第1页| 亚洲精品无码久久| 亚洲国产精品久久网午夜|