在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LPAR6 Antibody, FITC conjugated

  • 中文名稱:
    LPAR6兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA017336OC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) LPAR6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    LPAR6; P2RY5; Lysophosphatidic acid receptor 6; LPA receptor 6; LPA-6; Oleoyl-L-alpha-lysophosphatidic acid receptor; P2Y purinoceptor 5; P2Y5; Purinergic receptor 5; RB intron encoded G-protein coupled receptor
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Peptide sequence from Human Lysophosphatidic acid receptor 6 protein (292-313AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.
  • 基因功能參考文獻:
    1. Novel sequence variants in the LIPH and LPAR6 genes underlies autosomal recessive woolly hair/hypotrichosis in three consanguineous Pakistani families. PMID: 28425126
    2. DLD-C-F cells formed large-sized colonies, but not DLD-F-C cells, correlating with LPAR1 and LPAR6 gene expression levels. These results suggest that LPA1 and LPA6 may regulate the colony formation activity in DLD1 cells treated with anticancer drugs. PMID: 29369010
    3. LPA2 mRNA levels were associated with poorer differentiation, and higher LPA6 levels were associated with microvascular invasion in HCC; both became a risk factor for recurrence after surgical treatment when combined with increased serum ATX levels PMID: 27583415
    4. LPAR6 has a role in tumorigenicity of hepatocellular carcinoma PMID: 25589345
    5. These results suggest that the diverse roles of LPA4, LPA5 and LPA6 are involved in the activation of tumor progression in pancreatic cancer cells. PMID: 25849892
    6. Missense mutations in LPAR6 reveal abnormal phospholipid signaling pathways leading to hypotrichosis. PMID: 25119526
    7. We have identified a novel deletion mutation in LPAR6, which was responsible for autosomal woolly hair syndrome with hypotrichosis in a consanguineous Chinese family. PMID: 23773027
    8. study extends the spectrum of mutations in LPAR6/P2RY5 gene and underscores those mutations in LPAR6/P2RY5 and LIPH result in similar phenotypes PMID: 22385360
    9. LPA2 and LPA6 receptor subtypes are predominant in both HPAECs and HMVECs PMID: 23084965
    10. These findings extend the spectrum of known LPAR6 mutations and suggest a founder effect of the p.G146R mutation in the Pakistani population PMID: 22531990
    11. homozygous loss of the entire LPAR6 gene in a Turkish family with hypotrichosis and woolly hair PMID: 22621192
    12. Mutations identified in the present study extend the body of evidence implicating LPAR6 and LIPH genes in pathogenesis of human hereditary hair loss. PMID: 21426374
    13. Autosomal recessive form of hypotrichosis simplex mapped to chromosome 13q14.11-13q21.33, and identified homozygous truncating mutations in P2RY5. PMID: 18297070
    14. Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair. PMID: 18297072
    15. In the present study, 14 of 22 families with autosomal recessive hypotrichosis show linkage to LAH3 locus on chromosome 13q14.11-q21.32. Affected individuals of all the 22 families have common clinical features. PMID: 18461368
    16. Our findings show that mutations in P2RY5 display variable expressivity, underlying both hypotrichosis and woolly hair, and underscore the essential role of P2RY5 in the tissue integrity and maintenance of the hair follicle. PMID: 18692127
    17. There is an involvement of P2RY5 mutations in hereditary hair diseases. PMID: 18803659
    18. LIPH is a second causative gene for ARWH/hypotrichosis, giving rise to a phenotype clinically indistinguishable from P2RY5 mutations PMID: 18830268
    19. gene is involved in genetics of hypotrichosis simplex and autosomal recessive wooly hair syndrome. PMID: 19061667
    20. Mutations revealed in the results extend the body of evidence implicating the P2RY5 gene in the pathogenesis of human hereditary hair loss. PMID: 19292720
    21. study increases the spectrum of known P2RY5 mutations and highlights the importance of this receptor in human hair growth and texture PMID: 19529952
    22. Expression of turkey (Meleagris gallopavo) 6H1/p2y5 receptor in human astrocytoma cells and measurement of second mesenger levels indicate it is not a member of the P2Y receptor family. PMID: 9240460

    顯示更多

    收起更多

  • 相關疾病:
    Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1); Hypotrichosis 8 (HYPT8)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripher
  • 數據庫鏈接:

    HGNC: 15520

    OMIM: 278150

    KEGG: hsa:10161

    STRING: 9606.ENSP00000344353

    UniGene: Hs.123464



主站蜘蛛池模板: 日本久久综合久久鬼色| 女人的精水喷出来视频| 99国产精品久久久久久久成人 | 欧美成人精品午夜免费影视| 蜜臀av色欲a片无码一区二区| 越南毛茸茸的少妇| 人妻少妇被粗大爽9797pw| 国内偷自第一区二区三区| 国产精品_国产精品_k频道| 精品亚洲aⅴ在线无码播放| 国产又滑又嫩又白| 人妻aⅴ无码一区二区三区| 久久久久国色av免费看图片| 午夜嘿嘿嘿在线观看| 国产精品天干天干| 國产一二三内射在线看片| 成年无码动漫av片在线观看羞羞| 狠狠色狠狠色综合网老熟女| 久久久久久九九精品久| 深夜福利小视频在线观看| 国产成a人亚洲精品无码久久网| 国产成人+亚洲欧洲+综合| 亚洲精品综合一区二区三| 蜜臀视频一区二区在线播放| 亚洲裸男自慰gv网站| 免费国精产品自偷自偷免费看| 亚洲欧美日韩成人综合网| 少妇被粗大的猛烈进出动视频| 少妇人妻丰满做爰xxx| 日本熟妇色xxxxx日本免费看| 亚洲国产精品一区二区第四页| 久久综合国产乱子伦精品免费 | 亚洲熟妇av一区二区三区宅男| 在线永久无码不卡av| 亚洲精品国偷拍自产在线观看蜜桃| 亚洲国产精品无码久久久久高潮 | 5858s亚洲色大成网站www| av无码久久久久久不卡网站| 国产ae86亚洲福利入口| 国产成人无码激情视频| 亚洲日韩久久综合中文字幕 |