在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LPAR3 Antibody, FITC conjugated

  • 中文名稱:
    LPAR3兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA013049OC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) LPAR3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Calcium mobilizing lysophosphatidic acid receptor LP A3 antibody; Calcium mobilizing lysophosphatidic acid receptor LPA 3 antibody; Calcium mobilizing lysophosphatidic acid receptor LPA3 antibody; EDG 7 antibody; Endothelial cell differentiation gene 7 antibody; Endothelial differentiation lysophosphatidic acid G protein coupled receptor 7 antibody; FLJ98231 antibody; GPCR antibody; HOFNH 30 antibody; HOFNH30 antibody; LP A3 antibody; LPA 3 antibody; LPA receptor 3 antibody; LPA receptor EDG 7 antibody; LPA receptor EDG7 antibody; LPA-3 antibody; LPA3 antibody; LPAR 3 antibody; Lpar3 antibody; LPAR3_HUMAN antibody; Lysophosphatidic acid receptor 3 antibody; Lysophosphatidic acid receptor Edg 7 antibody; Lysophosphatidic acid receptor Edg-7 antibody; Lysophosphatidic acid receptor Edg7 antibody; OTTHUMP00000011573 antibody; RP4 678I3 antibody; RP4678I3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Peptide sequence from Human Lysophosphatidic acid receptor 3 protein (312-330AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.
  • 基因功能參考文獻:
    1. Using pharmacological activators and shRNA knockdown experiments, we demonstrate that activation of LPA3 inhibits megakaryopoiesis in human HSCs. In addition, pharmacological activation of LPA3 suppressed thrombopoiesis in zebrafish. PMID: 29239275
    2. The results indicate that LPA2 and LPA3 receptors play opposing roles during red blood cells differentiation. PMID: 27244685
    3. myeloma cells stimulate mesenchymal stem cells (MSCs to produce autotaxin, an indispensable enzyme for the biosynthesis of lysophosphatidic acid, and LPA receptor 1 (LPA1) and 3 (LPA3) transduce opposite signals to MSCs to determine the fate of MSCs. PMID: 27641212
    4. Expression profiles reveal LPAR3 (lysophosphatidic acid receptor 3) as a mediator for mitotic phosphorylation-driven pancreatic cell motility and invasion. Together, this work identifies YAP as a novel regulator of pancreatic cancer cell motility, invasion and metastasis. PMID: 26440309
    5. These data indicated that the expression of LPA receptor 3 was increased in human triple-negative breast cancers and is associated with tumor metastatic ability. PMID: 25209561
    6. Suggest that LPA2 and LPA3 may function as a molecular switch and play opposing roles during megakaryopoiesis of K562 cells. PMID: 25463482
    7. The results demonstrate LPA-stimulated migration in oral carcinoma cells through LPAR3, mediated further by PKC, which acts either in concert with or independently of EGFR transactivation PMID: 24928086
    8. LPA3 mRNA is clearly expressed in human PANC-1 tumor cells. PMID: 24061591
    9. Lysophosphatidic acid (LPA) increased hepatocellular carcinoma cells cell invasion, which was LPA-receptor dependent. PMID: 23569130
    10. in the normal human menstrual cycle, lysophosphatidic acid receptor 3 messenger RNA and protein expression change, indicating that this gene may be related to the function of the endometrium. PMID: 22872026
    11. The results indicated that LPA(3) acts as a positive regulator of cell motility and invasion in sarcoma cells, suggesting that LPA signaling pathway via LPA(3) may be involved in the progression of sarcoma cells. PMID: 23167620
    12. High LPAR3 expression is associated with aggressiveness of breast carcinoma. PMID: 22922883
    13. LPA3 Receptor act as a negative regulator on cell motile and invasive abilities of colon cancer. PMID: 22763559
    14. found that LPA receptor 2/3-mediated IL-8 expression occurs through Gi/PI3K/AKT, Gi/PKC and IkappaB/NF-kappaB signaling PMID: 21964883
    15. study found that LPS induces both ATX and LPA3 expression in THP-1 cells; the PKR and SPK1-mediated pathways are involved in both ATX and LPA3 induction, resulting in the coordinate up-regulation of these two genes PMID: 22314276
    16. Mutation in LPA3 gene indicate that the alterations in LPA receptor gene may play some role in pathogenesis in human osteosarcoma cells. PMID: 21116120
    17. Data show that CLL cells express LPA receptors LPA(1-5) and VEGF receptors, and the plasma levels of VEGF are elevated in CLL patients. PMID: 19860625
    18. show that human microglia express LPA receptor subtypes LPA(1), LPA(2), and LPA(3) on mRNA and protein level. LPA activation of C13NJ cells induced Rho and extracellular signal-regulated kinase activation and enhanced cellular ATP production. PMID: 19899077
    19. demonstrate that two biological fluids, blood plasma and seminal plasma, differentially activate LPA receptors PMID: 12123830
    20. results suggested that lysophosphatidic acid (LPA) receptors LPA(2) and LPA(3) may be involved in VEGF expression mediated by LPA signals in human ovarian oncogenesis PMID: 12668280
    21. data suggest that endothelial differentiation gene EDG-7 regulates Lysophosphatidic acid(LPA)-mediated mesangial cell proliferation and suggest that EDG-7 and EDG-2 LPA receptors play a diverse role in mesangial cell proliferation PMID: 15292052
    22. expression of LPA-induced inflammatory response genes is mediated by LPA1 and LPA3 PMID: 17923111
    23. Lysophosphatidic acid receptor 3 may contribute to the pathogenesis of rheumatoid arthritis through the modulation of fibroblast-like synoviocyte migration and cytokine production. PMID: 18006645
    24. Lysophosphatidic acid might regulate VEGF-C and lymphatic marker expression in endothelial cells, which contributes to endothelial cell tube formation in vitro and in vivo, thus facilitating endothelial cell participation lymphangiogenesis. PMID: 18627789
    25. Expression of LPA3 during ovarian carcinogenesis contributes to ovarian cancer aggressiveness, suggesting that the targeting of LPA production and action may have potential for the treatment of ovarian cancer. PMID: 19001604
    26. Switching of LPA receptor expression from LPA3 to LPA1, may be involved in prostate cancer progression and/or androgen independence PMID: 19025891
    27. LPA(1) receptor, LPA(2) and LPA(3) receptors-induced VASP phosphorylation is a critical mediator of tumor cell migration initiation PMID: 19081821
    28. LPA-stimulated cell growth is mediated by distinct but overlapping receptors and signaling pathways in these two model ovarian cancer cell lines. PMID: 19420982

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes
  • 數據庫鏈接:

    HGNC: 14298

    OMIM: 605106

    KEGG: hsa:23566

    STRING: 9606.ENSP00000359643

    UniGene: Hs.527909



主站蜘蛛池模板: 久久无码国产专区精品| 国产精品成人精品久久久| 精品人妻中文无码av在线| 快好爽射给我视频| 一本久久伊人热热精品中文字幕| 50岁熟妇的呻吟声对白| 夜夜春夜夜爽| 九色九九九老阿姨| 久久精品99av高久久精品| 亚洲日本精品国产一区vr| 国产精品久久久久久久久久妞妞 | av人摸人人人澡人人超碰小说| 伊人久久大香线蕉av综合| 国产午夜av秒播在线观看| 久久av一区二区三区| 伊人久久五月丁香综合中文亚洲| 精品久久久久久国产潘金莲| 人妻中文乱码在线网站| 亚洲精品无码一区二区| 亚洲另类无码专区国内精品| 77se77亚洲欧美在线| 国产成人精品免高潮在线观看| 在线观看无码av网址| 日本精品人妻无码77777| 欧洲-级毛片内射| 大伊香蕉在线精品视频75| 国产精品亚洲专区无码破解版| 亚洲乱码中文字幕综合| 成人高潮视频在线观看| 伊人狼人大焦香久久网| 国产av人人夜夜澡人人爽麻豆| 成在人线av无码免观看午夜网| 亚洲成国产人片在线观看| 亚洲精品在看在线观看高清| 无码人妻精品一区二区三区99不卡| 国产亚洲精品久久久性色情软件| av国産精品毛片一区二区视频| 日本少妇高潮喷水xxxxxxx| 国内精品卡一卡二卡三| 国产高清露脸孕妇系列| 欧美浓毛大泬视频|