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LOXHD1 Antibody

  • 中文名稱:
    LOXHD1兔多克隆抗體
  • 貨號:
    CSB-PA814211LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA814211LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA814211LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) LOXHD1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    LOXHD1
  • 別名:
    LOXHD1 antibody; Lipoxygenase homology domain-containing protein 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Lipoxygenase homology domain-containing protein 1 protein (1101-1366AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,LOXHD1 Antibody (CSB-PA814211LA01HU),的標記方式是Non-conjugated。對于LOXHD1 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA814211LB01HU LOXHD1 Antibody, HRP conjugated ELISA
    FITC CSB-PA814211LC01HU LOXHD1 Antibody, FITC conjugated
    Biotin CSB-PA814211LD01HU LOXHD1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in hearing. Required for normal function of hair cells in the inner ear.
  • 基因功能參考文獻:
    1. We report a Japanese family carrying compound heterozygotes of truncating and nontruncating mutations in LOXHD1 identified by targeted NGS analysis. The fact of lower degree of hearing impairment in our cases than previously reported and the molecular modeling of the missense mutant provide insight to the genotype-phenotype correlation of DFNB77. PMID: 26973026
    2. Mutations in LOXHD1 are identified in a Japanese population with sensorineural hearing loss. PMID: 25792669
    3. Authors identified a missense change in LOXHD1. Data implicate rare alleles in LOXHD1 in the pathogenesis of FCD and highlight how different mutations in the same locus can potentially produce diverse phenotypes. PMID: 22341973
    4. This is the second reported mutation in the LOXHD1 gene, and its homozygous presence in two of 39 Ashkenazi Jewish families with congenital ARNSHL suggest that it could account for some 5% of the familial cases in this community PMID: 21465660
    5. A founder mutation R1572X in the LOXHD1 causes autosomal recessive hearing loss in Ashkenazi Jews PMID: 21465660
    6. A mutation in LOXHD1, which causes DFNB77, a progressive form of autosomal-recessive nonsyndromic hearing loss (ARNSHL), was identified. PMID: 19732867

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  • 相關疾病:
    Deafness, autosomal recessive, 77 (DFNB77)
  • 亞細胞定位:
    Cell projection, stereocilium.
  • 數據庫鏈接:

    HGNC: 26521

    OMIM: 613072

    KEGG: hsa:125336

    STRING: 9606.ENSP00000300591

    UniGene: Hs.345877



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