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  4. LONP2 Antibody

LONP2 Antibody

  • 中文名稱：
    LONP2兔多克隆抗體
  • 貨號：
    CSB-PA060279
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    LONP2
  • 別名：
    Lon peptidase 2, peroxisomal antibody; Lon protease 2 antibody; Lon protease homolog 2 antibody; Lon protease homolog 2 peroxisomal antibody; Lon protease like protein 2 antibody; Lon protease-like protein 2 antibody; LONP antibody; lonp2 antibody; LONP2_HUMAN antibody; LONPL antibody; MGC4840 antibody; peroxisomal antibody; Peroxisomal Lon protease antibody; Peroxisomal Lon protease homolog 2 antibody; Peroxisomal LON protease like antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human LONP2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.
  • 基因功能參考文獻：
    1. Findings suggest that LONP2 promotes cervical tumorigenesis via oxidative stress. PMID: 29502128
    2. The proteolytic activity of oligomeric Tysnd1 is in turn controlled by self-cleavage of Tysnd1 and degradation of Tysnd1 cleavage products by PsLon. PMID: 22002062
    3. Lon recognizes specific surface determinants or folds, initiates proteolysis at solvent-accessible sites of MPPalpha and StAR, and generates unfolded polypeptides that are then processively degraded PMID: 15870080
  • 亞細胞定位：
    Peroxisome matrix.
  • 蛋白家族：
    Peptidase S16 family
  • 組織特異性：
    Widely expressed, with high levels in the liver, kidney and pancreas.
  • 數據庫鏈接：

    HGNC: 20598

    OMIM: 617774

    KEGG: hsa:83752

    STRING: 9606.ENSP00000285737

    UniGene: Hs.295923



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