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  4. LMP2 Antibody

LMP2 Antibody

Rare Species
  • 中文名稱：
    LMP2兔多克隆抗體
  • 貨號：
    CSB-PA321086HA01EFA
  • 規格：
    ￥440
  • 其他：

產品詳情

  • 產品描述：

    The LMP2 polyclonal antibody is an IgG that recognizes and binds specifically to the Epstein-Barr virus LMP2 protein. LMP2 mainly helps the Epstein-Barr virus evade the immune system and establish a persistent infection in host cells. Its activity is critical in the development of EBV-associated malignancies such as Hodgkin's lymphoma, Burkitt's lymphoma, and nasopharyngeal carcinoma.

    The LMP2 polyclonal antibody is generated from rabbits. The recombinant Epstein-Barr virus (1-147aa) is used as the immunogen. After protein G purification, this LMP2 antibody reaches up to 95% in purity. It is suitable for use in ELISA.

  • 產品名稱：
    Rabbit anti-Epstein-Barr virus LMP2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    LMP2
  • 別名：
    LMP2 antibody; Latent membrane protein 2 antibody; Terminal protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Epstein-Barr virus
  • 免疫原：
    Recombinant Epstein-Barr virus Latent membrane protein 2 protein (1-147AA)
  • 免疫原種屬：
    Epstein-Barr virus
  • 標記方式：
    Non-conjugated

    本頁面中的產品，LMP2 Antibody (CSB-PA321086HA01EFA)，的標記方式是Non-conjugated。對于LMP2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA321086HB01EFA LMP2 Antibody, HRP conjugated ELISA
    FITC CSB-PA321086HC01EFA LMP2 Antibody, FITC conjugated
    Biotin CSB-PA321086HD01EFA LMP2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs.; Isoform LMP2B may be a negative regulator of isoform LMP2A.
  • 基因功能參考文獻：
    1. In EBV-positive Hodgkin's lymphoma LMP2A-expressing HRS cells lacking BCR signalling functions cannot induce EGR1 and are consequently protected from entry to the virus lytic cycle. PMID: 23592216
    2. Epstein-Barr virus latent membrane protein 2A contributes to anoikis resistance through ERK activation. PMID: 23698301
    3. LMP2A, but not LMP2B, is critical for efficient long-term growth of B cells in vitro. PMID: 23308294
    4. LMP2A plays a role in the alteration of a cytokine that is important for both tumour survival and anti-tumour responses. PMID: 23303827
    5. LMP2A can affect a number of signaling pathways by regulating the phosphorylation of the ITSN1 and Shb adaptors. PMID: 22975684
    6. Data show that LMP2A enhances antigen presentation function. PMID: 22616025
    7. hnRNP K, when co-expressed with EBNA2, strongly enhances viral latent membrane protein 2A (LMP2A) expression. PMID: 22879910
    8. Epstein-Barr virus latent membrane protein-2A induces ITAM/Syk- and Akt-dependent epithelial migration through alphav-integrin membrane translocation PMID: 22837212
    9. Fra-1 was induced by Epstein-Barr virus LMP2A and is essential for LMP2A-triggered MMP9 expression. PMID: 22514348
    10. Widespread sequence variations in the LMP2A gene were found PMID: 22470549
    11. Studies suggest that LMP2A can also participate in EBV-induced epithelial cell growth transformation. PMID: 22249143
    12. EBV LMP2A is expressed in nasopharyngeal cancer. Cases with nasopharyngeal inflammation showed negative expression of LMP2A. PMID: 16124641
    13. Results confirmed that HPV L1 protein is potential to deliver multiepitope of EBV LMP2 as immunogen. PMID: 20705592
    14. LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. PMID: 20532215
    15. LMP2A uniquely makes resting B-cells sensitive to NF-kappaB inhibition and apoptosis and suggest that NF-kappaB may be a novel target to eradicate latently EBV-infected B-cells. PMID: 20484564
    16. LMP2A induces a heightened sensitivity to TLR ligand stimulation PMID: 16920914
    17. Expression of the EBV genes for latent membrane protein 1 and latent membrane protein 2A decreases FoxO1 expression.[LMP-2A] PMID: 16943287
    18. Phosphorylation of LMP2A is prevented by LMP2B. PMID: 17035319
    19. results indicate that cholesterol-dependent LMP2A trafficking determines the fate of LMP2A degradation PMID: 17150237
    20. The signalling scaffold Shb associates through SH2 and PTB domain interactions with phosphorylated tyrosine motifs in the LMP2A N-terminal tail. PMID: 17311000
    21. These results suggest that constitutive activation of the Ras/PI3-K/Akt pathway by LMP2A is a key factor for LMP2A-mediated transformation. PMID: 17582000
    22. All isolates from 7 Japanese nasal NK/T cell lymphomas showed the same amino acid change from serine to threonine at codon 348 in the CTL epitope SSCSSCPLSK of LMP2A. PMID: 17657160
    23. A role for LMP2A as an indispensable BCR mimic in certain B cells from which human B-cell tumors such as Hodgkin lymphoma originate. PMID: 17682125
    24. The results suggest that the combinatorial effects of DNA methylation, histone acetylation, and H3K4me2 modulate the activity of LMP2A promoter. PMID: 17898065
    25. These results demonstrate that LMP2A activates the Notch pathway in both B cells and epithelial cells, and exploits this pathway to regulate its own expresison. PMID: 17980397
    26. EBV uses its latent protein, LMP2A, to activate the NF-kappaB-survivin pathway to rescue EBV-infected epithelial cells from serum deprivation PMID: 18316606
    27. Despite the lack of pre-BCR expression, bone marrow B cells from TgE LMP2A mice proliferate and survive in low concentrations of interleukin 7, similar to wild-type cells. PMID: 18559925
    28. This demonstrates that the UGDH transcript and protein quantities, the enzyme activity, and glycosaminoglycan contents increase in LMP2A overexpressed human embryonic kidney 293 (HEK293) cells. PMID: 18717819
    29. LMP2A and the Notch1 pathway may cooperate to induce the alterations in B-cell identity seen in Hodgkin Reed-Sternberg cells PMID: 18815281
    30. LMP2B modulates the activity of LMP2A contributing to maintenance of Epstein-Barr virus latency. PMID: 18835714
    31. the immunoreceptor tyrosine-based activation motif (ITAM) of LMP-2A is important for HERV-K18 env transactivation PMID: 19070345
    32. c-Cbl promoted LMP2A degradation through ubiquitination, specifically degraded the Syk protein tyrosine kinase in the presence of LMP2A, and inhibited LMP2A induction of the EBV lytic cycle PMID: 19081591
    33. EBV LMP2A promotes tumor development by protecting pre-tumor B cells that would normally apoptose after the c-myc translocation. PMID: 19182823
    34. LMP2A can permit tumorigenesis in the presence of an intact p53 pathway, identifying an important contribution of EBV to Burkitt's lymphoma PMID: 19815507
    35. Our findings emphasize the role of miR-BART22 in modulating LMP2A expression PMID: 19881953

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  • 亞細胞定位：
    [Isoform LMP2A]: Host cell membrane; Multi-pass membrane protein.; [Isoform LMP2B]: Host endomembrane system; Multi-pass membrane protein. Host cytoplasm, host perinuclear region.
  • 蛋白家族：
    Herpesviridae LMP-2 family
  • 數據庫鏈接：

    KEGG: vg:3783751



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