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  4. LMAN2L Antibody, FITC conjugated

LMAN2L Antibody, FITC conjugated

  • 中文名稱：
    LMAN2L兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA863945LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) LMAN2L Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    LMAN2L
  • 別名：
    LMAN2L antibody; VIPL antibody; PSEC0028 antibody; UNQ368/PRO704 antibody; VIP36-like protein antibody; Lectin mannose-binding 2-like antibody; LMAN2-like protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human VIP36-like protein (45-313AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53.
  • 基因功能參考文獻：
    1. Homozygous missense mutation p.R53Q in the LMAN2L gene causes autosomal recessive intellectual disability and seizures. PMID: 26566883
    2. Study showed a significant association between LMAN2L and risk of both bipolar disorder and schizophrenia PMID: 24914473
    3. The results of this study suggested that significant novel association signals near the genes LMAN2L and provide supportive evidence for the previously reported association signals near ANK3 and within the 3p21.1 locus. PMID: 22182935
    4. VIPL terminates in the sequence KRFY, characteristic for proteins recycling between the ER and ERGIC/cis-Golgi; and knock-down of VIPL mRNA slowed secretion of two glycoproteins (35 and 250 kDa), suggesting that VIPL may function as an ER export receptor. PMID: 12878160
    5. selective interaction of VIPL and VIP36 with the deglucosylated trimannose in the D1 branch of high-mannose-type oligosaccharides but with different pH dependence. PMID: 18025080

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  • 相關疾病：
    Mental retardation, autosomal recessive 52 (MRT52)
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Predominantly found in the endoplasmic reticulum. Partly found in the Golgi.
  • 組織特異性：
    Expressed in numerous tissues. Highest expression in skeletal muscle and kidney, intermediate levels in heart, liver and placenta, low levels in brain, thymus, spleen, small intestine and lung.
  • 數據庫鏈接：

    HGNC: 19263

    OMIM: 609552

    KEGG: hsa:81562

    STRING: 9606.ENSP00000366280

    UniGene: Hs.655743



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