在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. LLGL1 Antibody, FITC conjugated

LLGL1 Antibody, FITC conjugated

  • 中文名稱：
    LLGL1兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA622993LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) LLGL1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    DLG4 antibody; DLG4, formerly antibody; Hugl 1 antibody; HUGL antibody; Hugl-1 antibody; HUGL1 antibody; Human homolog to the D-lgl gene protein antibody; L2GL1_HUMAN antibody; Lethal giant larvae homolog 1 (Drosophila) antibody; Lethal giant larvae homolog 1 antibody; Lethal(2) giant larvae protein homolog 1 antibody; LLGL antibody; Llgl1 antibody; Ly 49G2 antibody; Ly49G2 antibody; Mgl1 antibody; Mlgl antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Lethal (2) giant larvae protein homolog 1 protein (953-1056AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.
  • 基因功能參考文獻(xiàn)：
    1. loss of Llgl1 results in EGFR mislocalization, promoting pre-neoplastic changes PMID: 27542214
    2. these results revealed that miR-652-3p execute a tumor-promoter function in non-small cell lung cancer through direct binding and regulating the expression of Lgl1 PMID: 26934648
    3. Older age is a strong predictor of CNS involvement in patients seropositive for CASPR2-IgG or LGI1-IgG. Pain, peripheral manifestations, and stereotypic paroxysmal dizziness spells are common with LGI1-IgG. PMID: 28628235
    4. Reduced expression of Hugl 1 predicts poor survival in lung SqCC patients. The expression of Hugl 1 was inversely correlated with both overall survival rate and tumor stage. PMID: 26662669
    5. Our results support the growing appreciation that the tumour regulatory functions of Scribble, and other polarity protein family members, are context dependent. PMID: 25982280
    6. this study provides the evidence that Hugl-1 inhibits glioma cell growth in intracranial model of nude mice, suggesting that Hugl-1 might be a potential tumor target for glioma therapy. PMID: 26341367
    7. Lgl1 has a role in inhibiting glioblastoma PMID: 25426552
    8. PTEN loss leads to the phosphorylation and inactivation of Lgl by atypical protein kinase C in glioblastoma cells. PMID: 23907540
    9. Suggest that Hugl-1 induces growth suppression and apoptosis in a human esophageal squamous cell carcinoma cell line both in vitro and in vivo. PMID: 23864775
    10. inactivation of Llgl1 enhances hematopoietic stem cells self-renewal and fitness and is associated with unfavorable outcome in human acute myeloid leukemia PMID: 23277453
    11. Preservation of HUGL-1 expression in pancreatic adenocarcinoma is a good prognostic factor that contributes to a better overall survival PMID: 22843887
    12. Hugl-1 can act as a tumour suppressor in Drosophila and thus is the functional homologue of lgl PMID: 15467749
    13. downregulation of Hugl-1 contributes to colorectal cancer progression PMID: 15735678
    14. loss of Hugl-1 expression contributes to melanoma progression PMID: 16170365
    15. aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia PMID: 17369850
    16. loss of Hugl-1 expression in endometrial cancer may contribute to lymph node metastasis and it can be a factor of poor prognosis. PMID: 18074678
    17. Results provide the first evidence that Hugl-1 mRNA is frequently mutated by aberrant splicing exclusively in HCC, which may be involved in HCC progression. PMID: 19447873

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Early endosome membrane. Golgi apparatus, trans-Golgi network membrane. Golgi apparatus membrane. Cell projection, axon. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    WD repeat L(2)GL family
  • 組織特異性：
    Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6628

    OMIM: 600966

    KEGG: hsa:3996

    STRING: 9606.ENSP00000321537

    UniGene: Hs.513983



主站蜘蛛池模板： 久久麻豆成人精品av| 在办公室被c到呻吟的动态图| 欧美日韩视频无码一区二区三| 精品久久久久久中文字幕| 国产好爽…又高潮了毛片| 久久国产热精品波多野结衣av| 夜夜欢性恔免费视频| 精品久久久无码中文字幕一丶| 西西人体午夜大胆无码视频| 亚洲日韩国产精品第一页一区| 久久久午夜精品福利内容| 国产欧美日韩专区发布| 亚洲一区无码中文字幕| 人狥杂交一区欧美二区| 亚洲人成人无码www影院 | 高潮喷水的毛片| 亚洲综合无码一区二区三区| 国产区精品系列在线观看| 波多老师无码av中字专区| 亚洲精品无码专区在线播放| 亚洲色成人网站www永久| 日本大片免a费观看视频三区| 久久天天躁夜夜躁狠狠i女人 | 日本三级在线播放线观看视频 | 伊人色综合网久久天天| 亚洲午夜精品久久久久久浪潮| 国产成人一区二区三区影院动漫| 偷看农村女人做爰毛片色| 免费国产成人午夜福利电影| 精品一区二区三区在线播放视频 | 色综合亚洲一区二区小说| 一本一久本久a久久精品综合| 四川少妇大战4黑人| 国产无夜激无码av毛片| 天堂www天堂在线资源| 成人免费ā片在线观看| 欧美级特黄aaaaaa片| 熟女人妻高清一区二区三区| 野外亲子乱子伦视频丶| 丰满人妻被中出中文字幕| 国产精品无码日韩欧|