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  4. LIN9 Antibody, Biotin conjugated

LIN9 Antibody, Biotin conjugated

  • 中文名稱：
    LIN9兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA716370LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) LIN9 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    BARA antibody; Beta subunit-associated regulator of apoptosis antibody; Beta-subunit associated regulator of apoptosis antibody; hLin-9 antibody; huLin-9 antibody; lin-9 antibody; lin9 antibody; LIN9_HUMAN antibody; pRB-associated protein antibody; Protein lin-9 homolog antibody; TGS antibody; TUDOR gene similar protein antibody; Type I interferon receptor beta chain-associated protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Protein lin-9 homolog protein (5-103AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.
  • 基因功能參考文獻：
    1. High LIN9 expression is associated with Triple-negative breast cancers. PMID: 28807940
    2. The MuvB multiprotein complex, together with B-MYB and FOXM1 (MMB-FOXM1) regulate the expression of mitotic kinesins in breast cancer cells. PMID: 28061449
    3. LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression. PMID: 24475316
    4. Results show that E7 interacts with the B-Myb, FoxM1 and LIN9 components of this activator complex, leading to cooperative transcriptional activation of mitotic genes in primary cells and E7 recruitment to the corresponding promoters. PMID: 24141769
    5. Study links hTRM9L and tRNA modifications to inhibition of tumour growth via LIN9 and HIF1-alpha-dependent mechanisms. PMID: 23381944
    6. inactivation of LIN9, a subunit of DREAM, results in premature senescence, which can be overcome by the SV40 large T (LT) antigen PMID: 21860417
    7. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20360844
    8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    9. Human Lin-9 has tumor-suppressing activities and the ability of hLin-9 to inhibit transformation is mediated through its association with pRB. PMID: 15538385
    10. Mutation of BARA/LIN-9 restores the expression of E2F target genes. PMID: 16730350
    11. Mip/LIN-9 is required for the expression of B-Myb, and both proteins collaborate in the control of the cell cycle progression via the regulation of S phase and cyclin A, cyclin B, and CDK1 PMID: 17098733
    12. human LIN-9, together with B-MYB, has a critical role in the activation of genes that are essential for progression into mitosis PMID: 17159899
    13. The repressor complex that Mip/LIN-9 forms with p107 takes functional precedence over the transcriptional activation linked to the Mip/LIN-9 and B-Myb interaction. PMID: 17563750

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  • 亞細胞定位：
    Nucleus, nucleoplasm. Note=Found in perinucleolar structures. Associated with chromatin.
  • 蛋白家族：
    Lin-9 family
  • 組織特異性：
    Expressed in thymus and testis.
  • 數據庫鏈接：

    HGNC: 30830

    OMIM: 609375

    KEGG: hsa:286826

    STRING: 9606.ENSP00000329102

    UniGene: Hs.120817



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