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  4. LIN7A Antibody, FITC conjugated

LIN7A Antibody, FITC conjugated

  • 中文名稱：
    LIN7A兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA012963LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) LIN7A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    LIN7A
  • 別名：
    hLin-7 antibody; Lin 7 homolog A (C. elegans) antibody; LIN 7A antibody; Lin-7A antibody; LIN7 antibody; LIN7A antibody; LIN7A_HUMAN antibody; MALS-1 antibody; Mammalian LIN 7 1 antibody; Mammalian lin-seven protein 1 antibody; Protein lin-7 homolog A antibody; Tax interaction protein 33 antibody; TIP-33 antibody; Veli-1 antibody; VELI1 antibody; Vertebrate lin-7 homolog 1 antibody; Vertebrate LIN7 homolog 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Protein lin-7 homolog A protein (1-233AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
  • 基因功能參考文獻(xiàn)：
    1. Overexpression of LIN7 or IRSp53 did not prevent the formation of hyperfused mitochondria in cells coexpressing the Drp1 K38A mutant, thus suggesting that LIN7-IRSp53 complex requires functional Drp1 to regulate mitochondrial morphology. PMID: 27320196
    2. This study therefore shows that LIN7A has a crucial role in the polarity abnormalities associated with breast carcinogenesis. PMID: 26887652
    3. LIN7A depletion disrupts cerebral cortex development, contributing to intellectual disability in 12q21-deletion syndrome. PMID: 24658322
    4. LIN7A is a PDZ protein that interacts with human papillomavirus-16 E6 and forms a tripartite complex with MPP7 and DLG1, regulating the stability and localization of DLG1 to cell junctions. PMID: 17237226
    5. Allelic and haplotype association was found between both BDNF and adult ADHD, and LIN-7 and adult ADHD. PMID: 18286632

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  • 亞細(xì)胞定位：
    Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction. Cell junction, synapse, postsynaptic density membrane; Peripheral membrane protein. Cell junction, tight junction.
  • 蛋白家族：
    Lin-7 family
  • 組織特異性：
    Expressed in brain, testis, kidney, placenta and liver.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 17787

    OMIM: 603380

    KEGG: hsa:8825

    STRING: 9606.ENSP00000447488

    UniGene: Hs.144333



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