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LIM2 Antibody

  • 中文名稱:
    LIM2兔多克隆抗體
  • 貨號:
    CSB-PA012946ESR1HU
  • 規格:
    ¥440
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) LIM2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    LIM2
  • 別名:
    LIM2; Lens fiber membrane intrinsic protein; MP18; MP19; MP20
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Lens fiber membrane intrinsic protein (25-110AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.
  • 基因功能參考文獻:
    1. A novel missense mutation in LIM2 is responsible for autosomal recessive congenital cataracts. PMID: 27814360
    2. we report the absence of mutations in all studied genes in four families with phenotypes associating cataract, mental retardation and microcephaly. PMID: 22103961
    3. The genetic mutation in GJA3, GJA8, and LIM2 may slightly contribute to the development of age-related cataracts. PMID: 21386927
    4. Since the LIM2 gene promoter does not contain a classic TATA box, the Hsu element may serve as the site for binding the RNA polymerase complex. PMID: 15968979
    5. A missense mutation in the LIM2 gene is associated with autosomal recessive presenile cataract in an inbred Iraqi Jewish family PMID: 11917274
    6. This study shows the involvement of LIM2 in human congenital cataract. PMID: 18596884

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  • 相關疾病:
    Cataract, multiple types 19 (CTRCT19)
  • 亞細胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    PMP-22/EMP/MP20 family
  • 組織特異性:
    Eye lens specific.
  • 數據庫鏈接:

    HGNC: 6610

    OMIM: 154045

    KEGG: hsa:3982

    UniGene: Hs.162754



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