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  4. LGI4 Antibody, Biotin conjugated

LGI4 Antibody, Biotin conjugated

  • 中文名稱：
    LGI4兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA818678LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) LGI4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    LGI4
  • 別名：
    Leucine rich glioma inactivated gene 4 antibody; Leucine rich glioma inactivated protein 4 antibody; Leucine rich repeat LGI family member 4 antibody; Leucine-rich glioma-inactivated protein 4 antibody; Leucine-rich repeat LGI family member 4 antibody; LGI1 like protein 3 antibody; LGI1-like protein 3 antibody; LGI4 antibody; Lgi4 protein antibody; LGI4_HUMAN antibody; Lgil3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Leucine-rich repeat LGI family member 4 protein (292-412AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation.
  • 基因功能參考文獻：
    1. in four unrelated multiplex families presenting with severe arthrogryposis multiplex congenital, identified biallelic loss-of-function mutations in LGI4; functional tests showed these germline mutations caused aberrant splicing of the endogenous LGI4 transcript and in a cell-based assay impaired the secretion of truncated LGI4 protein PMID: 28318499
    2. Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals. PMID: 24662834
    3. The positive genotypic association between benign familial infantile convulsions (BFIC)and c.1722G/A polymorphism suggests that LGI4 might contribute to the susceptibility to BFIC. PMID: 19815358
    4. Schwann cells are the principal cellular source of Lgi4 in the developing nerve; transgenic Lgi4 binds directly to Adam22 without a requirement for additional membrane associated factors. PMID: 20220021
    5. Screening of the LGI4 coding region in BFIC and childhood absence epilepsy (CAE) revealed several frequent exonic polymorphisms. PMID: 14505228

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  • 相關疾病：
    Arthrogryposis multiplex congenita, neurogenic, with myelin defect (AMCNMY)
  • 亞細胞定位：
    Secreted.
  • 組織特異性：
    Widely expressed, with highest expression in brain.
  • 數據庫鏈接：

    HGNC: 18712

    OMIM: 608303

    KEGG: hsa:163175

    STRING: 9606.ENSP00000312273

    UniGene: Hs.65256



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