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  4. LCOR Antibody

LCOR Antibody

  • 中文名稱：
    LCOR兔多克隆抗體
  • 貨號：
    CSB-PA856960LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, A549 whole cell lysate
      All lanes: LCOR antibody at 4.6μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 48, 45, 107 kDa
      Observed band size: 48 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) LCOR Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    LCOR
  • 別名：
    A630025C20RIK antibody; C10orf12 antibody; FLJ38026 antibody; KIAA1795 antibody; LCoR antibody; LCOR_HUMAN antibody; Ligand dependent corepressor antibody; Ligand dependent nuclear receptor corepressor antibody; Ligand-dependent corepressor antibody; Mblk1 related protein 2 antibody; Mblk1-related protein 2 antibody; MLR2 antibody; RP11 175O19.1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Ligand-dependent corepressor protein (13-144AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，LCOR Antibody (CSB-PA856960LA01HU)，的標(biāo)記方式是Non-conjugated。對于LCOR Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA856960LB01HU LCOR Antibody, HRP conjugated ELISA
    FITC CSB-PA856960LC01HU LCOR Antibody, FITC conjugated
    Biotin CSB-PA856960LD01HU LCOR Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.
  • 基因功能參考文獻(xiàn)：
    1. Taken together, these results provide new insights into the mechanism of action of LCoR and RIP140 and highlight their strong interplay for the control of gene expression and cell proliferation in breast cancer cells. PMID: 28414308
    2. miR-199a promotes stem cell properties in mammary stem cells and breast cancer stem cells by directly repressing nuclear receptor corepressor LCOR, which primes interferon responses. PMID: 28530657
    3. LCoR recruitment by KLF6 regulates expression of the cyclin-dependent kinase inhibitor CDKN1A gene. PMID: 22277651
    4. Ligand-dependent corepressor acts as a novel androgen receptor corepressor, inhibits prostate cancer growth, and is functionally inactivated by the Src protein kinase. PMID: 21856747
    5. These results showed that the presence of miR-615-3p repressed the expression of LCoR, a derepressor of peroxisome proliferator-activated receptor gamma (PPARgamma). PMID: 21565892
    6. Data show that LCoR (ligand-dependent nuclear receptor corepressor) represents a class of corepressor that attenuates agonist-activated nuclear receptor signaling by multiple mechanisms [Ligand-dependent nuclear receptor corepressor]. PMID: 12535528
    7. HDAC6 can function as a cofactor of LCoR but they can act to enhance expression of specific estrogen-regulated genes PMID: 19744931
    8. role for LCoR and CtBP1 as attenuators of progesterone-regulated transcription, but LCoR and CtBP1 can act to enhance transcription of some genes PMID: 19744932

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  • 亞細(xì)胞定位：
    Nucleus.
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29503

    OMIM: 607698

    KEGG: hsa:84458

    STRING: 9606.ENSP00000348298

    UniGene: Hs.427927



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