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LBH Antibody, Biotin conjugated

  • 中文名稱:
    LBH兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA700659LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) LBH Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    LBH
  • 別名:
    hLBH antibody; lbh antibody; LBH_HUMAN antibody; Limb bud and heart development antibody; Limb bud and heart development homolog (mouse) antibody; Protein LBH antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein LBH protein (1-105AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway.
  • 基因功能參考文獻:
    1. LBH was significantly down-regulated in lung cancer tissue samples and was correlated with the prognosis and clinical characteristics of lung cancer patients. Survival analysis revealed that LBH-negative expression was associated with poor overall survival of LUAD patients (P = 0.021). PMID: 29788015
    2. Low LBH level, caused by a rheumatoid arthritis risk allele, is a risk factor for aggressive fibroblast-like synoviocyte behavior. PMID: 27159840
    3. The expression levels of LBH mRNA in patients with SLE were significantly decreased compared with those in normal controls (P < 0.001). No significant differences were found between LBH mRNA expression levels and SLE disease activity scores, SNP rs7579944 and rs906868. PMID: 26134586
    4. LBH normally induces NPC cell cycle arrest at the G1/S transition, and LBH can suppress the growth of transplanted NPC tumors in vivo by downregulating LMP1-mediated NF-kappaB transcriptional activity. PMID: 25557837
    5. LBH is a candidate gene for synovial pathology in rheumatoid arthritis. It is regulated by growth factors and modulates cell growth in primary fibroblast-like synoviocytes. PMID: 25707478
    6. results showed that the interaction of LBH and alphaB-crystallin may inhibit synergistically the transcriptional regulation of p53 and p21 PMID: 20587334
    7. LBH is aberrantly overexpressed in mammary tumors of mouse mammary tumor virus (MMTV)-Wnt1-transgenic mice and in aggressive basal subtype human breast cancers that display Wnt/beta-catenin hyperactivation. PMID: 20606007
    8. LBH is implicated as a candidate gene for congenital heart disease associated with partial trisomy 2p syndrome PMID: 15958514
    9. These results suggest that hLBH proteins may act as a transcriptional activator in mitogen-activated protein kinase signaling pathway to mediate cellular functions. PMID: 17390236

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  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    LBH family
  • 組織特異性:
    Highly expressed in heart, and expressed at low levels in placenta, lung, skeletal muscle, kidney and liver.
  • 數據庫鏈接:

    HGNC: 29532

    OMIM: 611763

    KEGG: hsa:81606

    STRING: 9606.ENSP00000378733

    UniGene: Hs.567598



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