在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LARP7 Antibody, FITC conjugated

  • 中文名稱:
    LARP7兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA672326LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) LARP7 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    DKFZp564K112 antibody; HDCMA18P antibody; La related protein 7 antibody; La ribonucleoprotein domain family member 7 antibody; La ribonucleoprotein domain family member 7 antibody; La-related protein 7 antibody; LARP 7 antibody; larp7 antibody; LARP7_HUMAN antibody; MGC104360 antibody; P TEFb interaction protein for 7SK stability antibody; P-TEFb-interaction protein for 7SK stability antibody; PIP7S antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human La-related protein 7 protein (409-471AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function. Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II. The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex. LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing. Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes. U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity. Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif. U6 snRNA processing is required for spermatogenesis.
  • 基因功能參考文獻:
    1. LARP7 may have inhibited the proliferation and increased the radioiodine uptake of PTC cells by regulating the SHH signaling pathway. PMID: 29620212
    2. a structural model for Larp7 binding to the 7SK 3' end and mechanism for 7SK RNP assembly. This work provides insight into how this domain contributes to 7SK recognition and assembly of the core 7SK RNP. PMID: 29946027
    3. LARP7 knockdown induces progressive time-dependent telomere shortening concomitant with a reduction in telomerase enzymatic activity and a decrease in full-length (catalytically active) TERT mRNA in vitro, and that humans with LARP7 deficiency display dramatically short telomeres, borderline anemia in younger generations, and anticipation consistent with a telomeropathy. PMID: 27766953
    4. The 7SK small nuclear RNP (snRNP), composed of the 7SK small nuclear RNA (snRNA), MePCE, and Larp7, also functions as a canonical transcription factor that, in collaboration with the little elongation complex (LEC) comprising ELL, Ice1, Ice2, and ZC3H8, promotes transcription of RNAPII-specific spliceosomal snRNA and small nucleolar RNA (snoRNA) genes. PMID: 28254838
    5. protein HEXIM with 7SKsnRNP complex comprising the non-coding RNA 7SK and proteins MePCE and LARP7. PMID: 25863285
    6. results suggest that LARP7 uses both its N- and C-terminal domains to stabilize 7SK in a closed structure, which forms by joining conserved sequences at the 5'-end with the foot of the 3' hairpin and has thus functional implications PMID: 25753663
    7. LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis. PMID: 25053741
    8. LARP7 is most likely recruited to the HIV-1 promoter in the presence of hnRNP A1. PMID: 24607481
    9. The results demonstrate that the La modules of the human LARP7 is also active in tRNA-mediated suppression, even in the absence of stable UUU-3'OH trailer protection. PMID: 23887937
    10. Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb. PMID: 23340209
    11. Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism PMID: 22865833
    12. LARP7 downregulation occurs early during gastric tumorigenesis and may promote gastric tumorigenesis via p-TEFb dysregulation. PMID: 22488152
    13. 7SK RNA thus establishes gene-dependent plasticity between HMGA1 chromatin remodeling and transcription initiation and P-TEFb transcription elongation. PMID: 21957495
    14. A combination of restrictive chromatin structures at the HIV long terminal repeat and limiting P-TEFb levels contribute to transcriptional silencing leading to latency in primary CD4(+) T cells. PMID: 20410271
    15. Results identify PIP7S as a La-related protein stably associated with and required for 7SK snRNP integrity. PMID: 18249148
    16. Results indicate LARP7 is a 7SK-binding protein. PMID: 18281698
    17. Results suggest that LARP7 is a negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. PMID: 18483487

    顯示更多

    收起更多

  • 相關疾病:
    Alazami syndrome (ALAZS)
  • 亞細胞定位:
    Nucleus, nucleoplasm.
  • 數據庫鏈接:

    HGNC: 24912

    OMIM: 612026

    KEGG: hsa:51574

    STRING: 9606.ENSP00000314311

    UniGene: Hs.713663



主站蜘蛛池模板: 亚洲欧洲日韩国内高清| 少妇高潮灌满白浆毛片免费看| 国产精品美女一区二区视频| 日产幕无线码三区在线| 日韩精品一区二区av在线| 国内一区二区三区香蕉aⅴ| 久久99精品网久久| 国产成年无码久久久久下载 | 亚洲午夜精品久久久久久浪潮| 国产亚洲视频中文字幕97精品| 精品久久久久国产免费| 精品一卡二卡三卡四卡网站| 成人做爰www网站视频下载| 久久婷婷五月综合97色一本一本| 免费无遮挡无码视频网站| 无码国产精品高清免费| 玩弄丰满少妇人妻视频| 野花社区在线观看视频| 日日摸天天摸爽爽狠狠97| 欧美18精品久久久无码午夜福利| 国产亚洲精品久久久ai换脸| 欧美熟妇性xxxx欧美熟人多毛| 欧美男生射精高潮视频网站 | 伊人久久大香线蕉在观看| 人妻三级日本三级日本三级极| 国产精品未满十八禁止观看| 双腿张开被9个男人调教| 天天爱天天做久久狠狠做| 久久精品国产日本波多野结衣| 无码人妻丰满熟妇啪啪| 白丝乳交内射一二三区| 人间精品视频在线播放| 亚洲国产欧美在线观看| 亚洲综合国产一区二区三区| 性中国妓女毛茸茸视频| 国产午夜福利久久精品| 国产乱视频在线观看| 欧洲亚洲国产成人综合色婷婷| 国产无遮挡又黄又爽网站| 欧美日韩在线第一页免费观看| 国产国产久热这里只有精品|