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  4. LANCL2 Antibody

LANCL2 Antibody

  • 中文名稱：
    LANCL2兔多克隆抗體
  • 貨號：
    CSB-PA865129LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, U87 whole cell lysate
      All lanes: LANCL2 antibody at 3.5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 51 kDa
      Observed band size: 51 kDa
    • IHC image of CSB-PA865129LA01HU diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA865129LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) LANCL2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    G protein coupled receptor 69B antibody; GPR69B antibody; LanC (bacterial lantibiotic synthetase component C) like 2 antibody; LanC-like protein 2 antibody; LANC2_HUMAN antibody; LANCL2 antibody; TASP antibody; Testis specific adriamycin sensitivity protein antibody; Testis-specific adriamycin sensitivity protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human LanC-like protein 2 protein (2-106AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，LANCL2 Antibody (CSB-PA865129LA01HU)，的標記方式是Non-conjugated。對于LANCL2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA865129LB01HU LANCL2 Antibody, HRP conjugated ELISA
    FITC CSB-PA865129LC01HU LANCL2 Antibody, FITC conjugated
    Biotin CSB-PA865129LD01HU LANCL2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.
  • 基因功能參考文獻：
    1. human LANCL2 is a non-transmembrane G protein-coupled receptor susceptible to hormone-induced nuclear translocation. PMID: 27222287
    2. Data indicate that lanthionine synthetase C-like 2 (LanCL2) depletion sensitizes cells to apoptosis through down-regulating serine/threonine protein kinase Akt phosphorylation. PMID: 25273559
    3. human recombinant LANCL2 binds abscisic acid (ABA) directly and provide the first demonstration of ABA binding to a mammalian ABA receptor. PMID: 22037458
    4. Molecular docking studies predict that ABA and other PPAR gamma agonists (e.g., rosiglitazone and pioglitazone) share a binding site on the surface of LANCL2. PMID: 20512604
    5. cDNA cloned and characterized. May play a role as a component of a peptide-modifying complex PMID: 11762191
    6. Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P-glycoprotein through a transcription-mediated mechanism. PMID: 12566319
    7. Data show that lanthionine synthetase C-like protein (LANCL2) is required for abscisic acid binding on human granulocyte membranes and that LANCL2 is necessary for transduction of the ABA signal into granulocytes and rat insulinoma cells. PMID: 19667068

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  • 亞細胞定位：
    Nucleus. Cytoplasm. Cell membrane.
  • 蛋白家族：
    LanC-like protein family
  • 組織特異性：
    Expressed in brain and testis.
  • 數據庫鏈接：

    HGNC: 6509

    OMIM: 612919

    KEGG: hsa:55915

    STRING: 9606.ENSP00000254770

    UniGene: Hs.595384



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