在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. LAMTOR1 Antibody, FITC conjugated

LAMTOR1 Antibody, FITC conjugated

  • 中文名稱：
    LAMTOR1兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA757083LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) LAMTOR1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    C11orf59 antibody; LAMTOR1 antibody; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1 antibody; Lipid raft adaptor protein p18 antibody; LTOR1_HUMAN antibody; p18 antibody; p27Kip1-releasing factor from RhoA antibody; p27RF-Rho antibody; PDRO antibody; PP7157 antibody; Protein associated with DRMs and endosomes antibody; Ragulator complex protein LAMTOR1 antibody; ragulator complex protein PDRO antibody; Ragulator1 antibody; RhoA activator C11orf59 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ragulator complex protein LAMTOR1 protein (2-161AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
  • 基因功能參考文獻：
    1. In vitro reconstitution and experiments with site-directed mutagenesis defined the physiological importance of LAMTOR1 in assembling the remaining components to ensure fidelity of mTORC1 signaling. PMID: 28935770
    2. LAMTOR1 is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning. PMID: 28993467
    3. Study found that NF1 negatively regulates mTOR signaling in a LAMTOR1-dependent manner. In addition, the cell growth and survival of NF1-deficient cells have become dependent on hyperactivation of the mTOR pathway, and the tumorigenic properties of these cells have become dependent on LAMTOR1. PMID: 28174230
    4. Western blot experiments designed to detect flotillin 2, TMEM256, Rab3B and LAMTOR1 showed that the level of these proteins was higher in urinary exosomes from prostate cancer patients compared to healthy males PMID: 27664330
    5. Data suggest that ablation of p18/LAMTOR1 suppresses starvation-induced cell death by stimulating autophagy through modulation of p27(kip1) activity. PMID: 26032166
    6. LAMTOR1 expression affects the tuning of lysosomal activation that can lead to p53-dependent apoptosis through excessive catabolism. PMID: 22513874
    7. A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC. PMID: 21087931
    8. MT1-MMP-associated protein p27RF-Rho binds p27(kip1) and prevents p27(kip1) from binding to RhoA. [p27RF-Rho] PMID: 19654316
    9. A complex encoded by the MAPKSP1, ROBLD3, and c11orf59 genes interacts with the Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation PMID: 20381137
    10. Studies in rat and mice, identified the rat p18 protein as an endosomal membrane anchoring protein which interacts with MEK1 scaffold p14/MP1 and mobilizes them to late endosome. PMID: 19177150

    顯示更多

    收起更多

  • 亞細胞定位：
    Late endosome membrane; Lipid-anchor; Cytoplasmic side. Lysosome membrane; Lipid-anchor; Cytoplasmic side. Cell membrane.
  • 蛋白家族：
    LAMTOR1 family
  • 數據庫鏈接：

    HGNC: 26068

    OMIM: 613510

    KEGG: hsa:55004

    STRING: 9606.ENSP00000278671

    UniGene: Hs.731528



主站蜘蛛池模板： 色欲αv一区二区三区天美传媒| 国产日产亚洲系列最新| 美女内射视频www网站午夜| 超碰cao已满18进入离开官网| 国产成人精品免费视频大全软件| 国产精品无码av一区二区三区 | 亚洲一卡一卡二新区迎热烈讨论| 免费乱码人妻系列无码专区| 久久精品国产精品亚洲色婷婷 | 亚洲中文字幕精品久久久久久动漫| 国产精品_九九99久久精品| 男男又爽又黄又无遮挡网站| 99精品视频九九精品视频| 久久综合给合久久狠狠狠97色69| 色欲av永久无码精品无码| 国产欧美丝袜在线二区| 亚洲精品乱码久久久久久自慰| 久久午夜夜伦鲁鲁片免费无码| 国产亚洲视频在线观看播放| 久久无码中文字幕免费影院| 777天堂麻豆爱综合视频| 日韩毛片在线视频x| 美女mm131爽爽爽作爱| 老湿机香蕉久久久久久| 男人j进女人p免费视频| 337p人体粉嫩胞高清视频| 国产99久9在线视频 | 传媒| 色欲综合久久中文字幕网| 亚洲色成人中文字幕网站| 乱人伦中文视频在线| 超caopor在线公开视频| 国产在线视频一区二区三区| 51国产黑色丝袜高跟鞋| 亚洲制服 视频在线观看| 国产99视频精品免费视看6| 92国产精品午夜福利| 色婷婷五月综合激情中文字幕| 亚洲国产成人久久一区| 亚洲人成在线影院| 四虎永久在线精品免费视频观看 | 亚洲欧美日韩国产国产a|