在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. LAMP3 Antibody

LAMP3 Antibody

  • 中文名稱：
    LAMP3兔多克隆抗體
  • 貨號：
    CSB-PA008859
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of MCF7 cells using DC-LAMP Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    LAMP3
  • 別名：
    CD208 antibody; CD208 antigen antibody; DC LAMP antibody; DC lysosome associated membrane glycoprotein antibody; DC-lysosome-associated membrane glycoprotein antibody; DCLAMP antibody; LAMP antibody; LAMP 3 antibody; LAMP-3 antibody; Lamp3 antibody; LAMP3_HUMAN antibody; Lysosomal associated membrane protein 3 antibody; Lysosomal-associated membrane protein 3 antibody; Lysosome-associated membrane glycoprotein 3 antibody; Protein TSC403 antibody; TSC403 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human DC-LAMP.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction. Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process. Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway. May also play a role in dendritic cell function and in adaptive immunity.; (Microbial infection) Plays a positive role in post-entry steps of influenza A virus replication, either virus uncoating, cytosolic transport, or nuclear import of viral components, and promotes nuclear accumulation of influenza nucleoprotein/NP at early stages of viral infection.; (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.; (Microbial infection) Promotes the intracellular proliferation of Salmonella typhimuium.
  • 基因功能參考文獻：
    1. Knockdown of LAMP3 significantly inhibited OS cell viability and promoted apoptosis. TP53, which is involved in the apoptosis pathway, was found to be highly upregulated after knockdown of LAMP3. PMID: 30008754
    2. LAMP3 promotes the invasion of osteosarcoma cells via SPP1 signaling. PMID: 28849219
    3. mRNA and protein levels of LAMP3 were significantly higher in oral squamous carcinoma tissues than in adjacent normal tissues. High LAMP3 expression was linked to the degree of tumor differentiation and stage. PMID: 28607528
    4. LAMP3 variants found to be associated with Bipolar disorder or Schizophrenia in other populations are also associated with Bipolar disorder risk in Latinos. PMID: 27759212
    5. this study shows that the vitamin D3 reduce the LAMP3 expression during the dendritic cells differentiation and maturation, via NFkappaB pathways PMID: 27697285
    6. Immunohistochemical results showed that high lysosome-associated membrane protein 3 cytoplasmic expression was significantly related to tumor grade ( p = 0.038), lymph node metastasis ( p = 0.049), metastasis ( p < 0.001), level of CA125 ( p = 0.030), and International Federation of Gynecology and Obstetrics (FIGO) ( p < 0.001). PMID: 28349821
    7. study indicates that LAMP-3 is induced by Salmonella infection and recruited to the Salmonella pathogen for intracellular proliferation. PMID: 27329040
    8. In laryngeal squamous cell carcinoma, high LAMP3 and high TP53 protein expression was significantly associated with tumor stage and size and patients with high expression of these proteins had poor overall survival. PMID: 26191259
    9. our results suggest that epithelial LAMP3 expression is an independent prognostic biomarker for esophageal squamous cell carcinoma . PMID: 26263981
    10. LAMP3 gene expression is relevant for prognosis in squamous cell carcinoma of head and neck. PMID: 24634103
    11. LAMP3 and TP53 protein expression was significantly higher in cancerous gastrointestinal tissues compared to normal and benign tissues; only LAMP3 expression correlated with poor overall survival PMID: 25362357
    12. LAMP3 regulation as part of the unfolded protein response contributes to protein degradation and cell survival during proteasomal dysfunction. PMID: 25681212
    13. the PERK/ATF4/LAMP3-arm of the UPR is an additional pathway mediating hypoxia-induced breast cancer cell migration PMID: 23294542
    14. the MCCC1/LAMP3 gene can decrease the risk of Parkinson disease in Chinese population. PMID: 24631562
    15. Increase in CD208+ dendritic cells in tonsils is associated with immunoglobulin A nephropathy PMID: 24081865
    16. LAMP3 knockdown in MCF7 breast cancer cells increases tamoxifen sensitivity. PMID: 24434718
    17. the association between hypoxia, metastasis, and poor prognosis is due, in part, to hypoxic activation of the unfolded protein response and expression of LAMP3. PMID: 24045183
    18. LAMP3 is a driver of interferon related genes as demonstrated by siRNA experiments and by gene expression in cervical carcer samples. PMID: 23651994
    19. These results suggest that Treg-DC interactions may promote chronic H. pylori infection by rendering gastric DCs tolerogenic. PMID: 23876802
    20. DC-LAMP and DC-SIGN may be involved in the pathogenesis of condyloma acuminatum. PMID: 23569139
    21. The crystal structure of the conserved domain of human DC-LAMP was solved. PMID: 22809326
    22. LAMP3 is an influenza A virus inducible gene, and plays an important role in viral post-entry steps. PMID: 21810281
    23. In the current breast cancer cohorts, LAMP3 had independent prognostic value. PMID: 21319150
    24. Both DC-LAMP and DC-SIGN proteins may be involved in the pathogenesis of psoriasis vulgaris. PMID: 21596034
    25. Data show that the ABCA3 N-terminus is proteolytically removed inside acidic LAMP3-positive vesicles MVB/LB. PMID: 20863830
    26. Findings indicate that LAMP3 overexpression is associated with an enhanced metastatic potential and may be a prognostic factor for cervical cancer. PMID: 16204031
    27. LAMP-1 and DC-LAMP antigen chimeras follow different trafficking pathways, induce distinct modulatory immune responses, and are able to present cryptic epitopes. PMID: 16887987
    28. DC-LAMP staining was lost in solid type adenocarcinomas but persisted in well-differentiated areas and there was no prognostic difference in tumors that reacted with DC-LAMP. PMID: 17056097
    29. DC-LAMP has a role in preventing the progression of micrometastatic melanoma in lymph nodes PMID: 17606713
    30. In rheumatoid arthritis patients, the number of CD304(+) plasmacytoid DCs (pDCs) exceeded that of CD1c(+) myeloid DCs (mDCs), with the majority of infiltrating DCs being CD83(-) or DC-LAMP(-). PMID: 18292234
    31. Because a defect of the granular layer in psoriatic lesions has been recognized, increased expression of lysosome-related CD208 in the basal and suprabasal keratinocytes of psoriatic lesions might represent aberrant epidermal differentiation. PMID: 19335688

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell surface. Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    LAMP family
  • 組織特異性：
    Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in c
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14582

    OMIM: 605883

    KEGG: hsa:27074

    STRING: 9606.ENSP00000265598

    UniGene: Hs.518448



主站蜘蛛池模板： 精品无码久久久久久久久久| 免费视频爱爱太爽了网站| 琪琪午夜伦埋影院77| 蜜桃网站入口在线进入| 男人扒开女人双腿猛进视频| 亚洲无日韩码精品| 免费乱理伦片在线观看| 免费无码av片流白浆在线观看| 粗大的内捧猛烈进出在线视频 | 青青国产线免观| 日本xxxx色视频在线观看| 国产精品免费视频色拍拍| 丰满肥臀大屁股熟妇激情视频| 性欧美激情aa片在线播放| 暖暖的在线观看日本社区| 日本一道高清一区二区三区| 久久精品国产99国产精品| 欧美gv在线观看| 国产欧美综合在线观看第十页| 免费的污污的网站在线观看| 乱女伦露脸对白在线播放| 久国产精品人妻aⅴ| 亚洲中文字慕日产2021| 人妻 校园 激情 另类| 熟睡人妻被讨厌的公侵犯深田咏美| 高清性欧美暴力猛交| 久热这里只有精品12| 在线观看特色大片免费网站| 成在人线av无码免观看麻豆| 2021年精品国产福利在线| 北条麻妃在线一区二区| 毛茸茸性xxxx毛茸茸毛茸茸| 末发育娇小性色xxxxx| 亚洲午夜无码久久久久软件| а天堂中文官网| 天堂网www天堂在线资源| 波多野结衣潮喷视频无码42| 久久99国产乱子伦精品免费| 精品国产小视频在线观看| 真人啪啪高潮喷水呻吟无遮挡| 国产成人av一区二区三区|