在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LAMB3 Antibody

  • 中文名稱:
    LAMB3兔多克隆抗體
  • 貨號:
    CSB-PA009773
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    BM600 125KDA antibody; Epiligrin subunit bata antibody; FLJ99565 antibody; Kalinin B1 chain antibody; Kalinin subunit beta antibody; LAM5 antibody; LAMB3 antibody; LAMB3_HUMAN antibody; Laminin B1k chain antibody; Laminin subunit beta-3 antibody; Laminin-5 subunit beta antibody; LAMNB1 antibody; Nicein subunit beta antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human Laminin β-3.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • 基因功能參考文獻:
    1. From these results, it was shown that laminin-332 is an essential niche component for the proper differentiation of Interfollicular epidermal stem cells. PMID: 29555367
    2. the gentamicin-induced laminin beta3 led to the restoration of laminin 332 assembly, secretion, and deposition within the dermal/epidermal junction, as well as proper polarization of alpha6beta4 integrin in basal keratinocytes PMID: 29946029
    3. Results show three specific LAMB3 mutations: c.823-1G>A, c.957ins77 and c.3228+1G>A are carried by 91% of all LAMB3 alleles and that at least one of these three mutations will be carried in junctional epidermolysis bullosa individuals in this Chilean population. PMID: 27480391
    4. expression in preoperative biopsy material predictive of perineural invasion in patients with oral squamous cell carcinoma PMID: 27863864
    5. The authors have identified a mutation in LAM3 causing lethal epidermolysis bullosa in a Balkan, Hungarian, population. Investigations into the genetic background of its unique carrier group, suggests that the estimated age of the mutation corresponds to the period of Roma migration in the Balkans. PMID: 27062385
    6. the tyrosine kinase FAK and the laminin subunit LAMB3 as functional targets of miR-1298. Silencing of FAK or LAMB3 recapitulated the synthetic lethal effects of miR-1298 expression in KRAS-driven cancer cells. PMID: 27698189
    7. The expression of fascin-1 and lanminin-5 and the serum levels of fascin-1 and laminin-5 were related to the relapse of patients with non-small cell lung cancer. PMID: 28653739
    8. Whole-Exome Sequencing Suggests LAMB3 as a Susceptibility Gene for Morbid Obesity PMID: 27431458
    9. Case Reports: Junctional epidermolysis bullosa with LAMB3 splice-site mutations. PMID: 25708563
    10. LNbeta3 expression may play a key role in the progression and prognosis of pancreatic ductal adenocarcinoma. PMID: 25032755
    11. Screening of ENAM and LAMB3 genes was performed by direct sequencing of genomic DNA from blood samples. PMID: 25769099
    12. Case Report: linear IgA/IgG bullous dermatosis with anti-laminin-332 autoantibodies. PMID: 24978847
    13. An algorithm combining CLDN10, HMGA2, and LAMB3 transcripts was able to discriminate tumors from BTL samples (94% sensitivity and 96% specificity in validation set). PMID: 25867809
    14. Novel LAMB3 mutations cause non-syndromic amelogenesis imperfecta with variable expressivity. PMID: 24494736
    15. we report a case of Herlitz junctional epidermolysis bullosa with a novel heterozygous mutation in LAMB3,c.1597G>A (p.Ala533Thr). PMID: 23278291
    16. However, to our knowledge, this is the first report of dominant AI due to a LAMB3 mutation in the absence of JEB. PMID: 23632796
    17. data further enhance the mutation spectrum of the LAMB3 and the COL7A1 genes, and also underscore the crucial roles of these genes in pathogenesis of epidermolysis bullosa PMID: 23769655
    18. an 8-bp deletion (c.3446_3453del GACTGGAG) shifting the reading frame (p.Gly 1149Glufs*8) and a single nucleotide substitution (c.C3431A) generating an in-frame translation termination codon (p.Ser1144*)associated with amelogenesis imperfecta PMID: 23958762
    19. Results identify the point during neoplastic progression in epithelia when the tumor suppressor p16 and laminin 5 are expressed and suggest that normal epithelia may use the same mechanism to generate non-dividing, motile cells for wound repair. PMID: 12875969
    20. Laminin-5 is a useful biomarker in the evaluation of invasiveness in cervical adenocarcinoma. PMID: 22898004
    21. These results suggest that epigenetic activation of LAMB3 and LAMC2 may play an important role in gastric carcinogenesis. PMID: 21345334
    22. The LAMB3 rs2566 variant CT/TT genotypes were associated with a significantly increased risk of cervical cancer, compared with the wild type CC genotype. PMID: 20163849
    23. Gene LAMB3 detected compound heterozygosity for the nonsense mutation R635X and a novel 2 bp deletion (1587delAG) resulting in a downstream premature termination codon. PMID: 11689492
    24. Deletion analysis of laminin-beta3 indicated that the region comprising aa 726 to 875 of laminin-beta3 interacts with rotavirus enterotoxin NSP4. PMID: 15331737
    25. In squamous cell carcinoma of the tongue and colorectal carcinoma, laminin 5 beta3 chain is important in the invasiveness of cancer cells. PMID: 15363037
    26. homozygous frameshift mutation in LAMB3 was associated to illegitimate splicing leading to non-H junctional epidermolysis bullosa PMID: 15373767
    27. DNA analysis revealed a compound heterozygote for mutations 2379delG and Q995X in the LAMB3 gene in Herlitz junctional epidermolysis bullosa PMID: 16147969
    28. Multiple second-site mutations, all correcting the germline mutation LAMB3 (628G-->A;Glu210Lys), are present in 2 unrelated non-Herlitz junctional epidermolysis bullosa patients with revertant mosaicism. PMID: 17476356
    29. degradation [by Candida species] can exert functional disturbances on basement membrane integrity, possibly aiding Candida cell invasion into tissues PMID: 18284540
    30. The expression of LAMB3 mrna was higher in malignant tissue and correlated with the depth of invasion and venous invasion in ESCC. PMID: 18331784
    31. c.1945dupG mutation in Herlitz junctional epidermolysis bullosa PMID: 18387282
    32. Ln-332 gamma2 may be a therapeutic target against metastatic colon cancer because a lowered beta3:gamma2 ratio would reduce expression of heterotrimeric Ln-332 and increase monomeric gamma2 secretion. PMID: 19383890
    33. Histopathology of anti-laminin 5 mucous membrane pemphigoid is characterized by subepidermal blistering and a sparse to moderate superficial lymphohistiocytic infiltrate with neutrophils and/or eosinophils PMID: 19700013
    34. Results suggest that laminin (LN)gamma2 and LNbeta3, in conjunction with MMP7, play a key role in the progression of biliary tract cancer. PMID: 19701966

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Epidermolysis bullosa, junctional, Herlitz type (H-JEB); Generalized atrophic benign epidermolysis bullosa (GABEB); Amelogenesis imperfecta 1A (AI1A)
  • 亞細胞定位:
    Secreted, extracellular space, extracellular matrix, basement membrane.
  • 組織特異性:
    Found in the basement membranes (major component).
  • 數據庫鏈接:

    HGNC: 6490

    OMIM: 104530

    KEGG: hsa:3914

    STRING: 9606.ENSP00000348384

    UniGene: Hs.497636



主站蜘蛛池模板: 女人被躁到高潮免费视频 | 国产精品无码电影在线观看| 99re久久资源最新地址| 人人妻人人爽人人添夜夜欢视频| 大地资源中文在线观看官网第二页| 久久亚洲一区二区三区四区| 午夜亚洲www湿好爽| 少妇人妻综合久久中文字幕| 亚洲中文字幕无码人在线| 日产精品1区2区3区| 国产精品扒开腿做爽爽爽a片唱戏| 久久久久久成人毛片免费看| 成人欧美一区二区三区黑人| 永久免费的无码中文字幕| 麻豆人妻无码性色av专区 | 亚洲精品美女久久久久久久| 亚洲国产午夜精品理论片在线播放| 高潮喷吹一区二区在线观看| 亚洲一区二区色情苍井空| 国产色秀视频在线播放| 在线a亚洲视频播放在线观看| 国产精品欧美一区二区三区| 精品国产乱码久久久久久乱码| 天下第一社区视频www日本| 亚洲人成色77777在线观看大战p | 亚洲成av人片在www| 骚动漫十八禁在线观看| 无码aⅴ在线观看| 麻豆国产尤物av尤物在线观看| www内射国产在线观看| 精品久久综合1区2区3区激情| 性欧美暴力猛交69hd| 欧美 国产 日产 韩国 在线| 天堂8а√中文在线官网| 亚洲精品在看在线观看高清| 色欲av永久无码精品无码蜜桃| 97精品久久天干天天| 99久久国产综合精品五月天| 国产精品无码一区二区三区电影| 日本孕妇潮喷高潮视频| 久久99er精品国产首页|