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  4. L3MBTL2 Antibody, FITC conjugated

L3MBTL2 Antibody, FITC conjugated

  • 中文名稱：
    L3MBTL2兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA839279LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) L3MBTL2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    L3MBTL2
  • 別名：
    3bt like 2 protein antibody; 3bt like protein antibody; DKFZP761I141 antibody; H-l(3)mbt-like protein 2 antibody; H-l(3)mbt-like protein antibody; Hl antibody; Hl(3)mbt like protein antibody; Hl(3)mbtl antibody; L antibody; l(3)mbt like 2 (Drosophila) antibody; l(3)mbt like 2 antibody; L(3)mbt-like 2 protein antibody; L(3)mbt-like protein 2 antibody; L3MBTL2 antibody; Lethal antibody; Lethal(3)malignant brain tumor-like 2 protein antibody; Lethal(3)malignant brain tumor-like protein 2 antibody; LMBL2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Lethal(3)malignant brain tumor-like protein 2 protein (1-230AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.
  • 基因功能參考文獻：
    1. L3MBTL2 polymorphism is associated with neuroticism. PMID: 27918536
    2. Our findings highlight a PcG/L3MBTL2 collaboration that attains repressive chromatin without entailing histone lysine methylation marks. PMID: 21596310
    3. High-resolution crystallographic analysis of the four MBT repeats of L3MBTL2 reveals its unique asymmetric rhomboid architecture, as well as binding mechanism, which preclude the interaction of the first three MBT repeats with methylated peptides. PMID: 19233876
    4. determination of the solution structure of the FCS zinc finger of L3MBTL2; structure consists of a beta-hairpin followed by an alpha-helix; structure is consistent with the proposal that FCS zinc fingers bind to regulatory RNAs PMID: 19241375
  • 亞細胞定位：
    Nucleus.
  • 數據庫鏈接：

    HGNC: 18594

    OMIM: 611865

    KEGG: hsa:83746

    STRING: 9606.ENSP00000216237

    UniGene: Hs.517641



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