在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KSR2 Antibody

  • 中文名稱:
    KSR2兔多克隆抗體
  • 貨號:
    CSB-PA581207
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from COS7, 293 and 3T3 cells, using KSR2 antibody.
    • Immunofluorescence analysis of HeLa cells, using KSR2 antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) KSR2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from internal of Human KSR2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1. Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
  • 基因功能參考文獻(xiàn):
    1. These observations suggest that, in the brain, KSR2 regulates energy balance via control of feeding behavior and adaptive thermogenesis, while a second KSR2-dependent mechanism, functioning through one or more other tissues, modulates sensitivity to leptin and activators of the energy sensor AMPK. PMID: 28180061
    2. A pleiotropic effect of KSR2-rs7973260 was found on the risk of metabolic syndrome, severe hypertriglyceridemia, and diabetes. PMID: 28537769
    3. KSR2 deficiency affects stromal interaction molecule 1 (STIM1)/ORAI1 puncta formation, which is correlated with cytoskeleton disorganization. PMID: 24672054
    4. Study explored the role of KSR2 in humans by sequencing 2,101 individuals with severe early-onset obesity and identified multiple rare variants in KSR2 that disrupt signaling through the Raf-MEKERK pathway and impair cellular fatty acid oxidation and glucose oxidation in transfected cells. PMID: 24209692
    5. study demonstrated that miR-31 upregulated IL-2 expression via reduction of its up-stream kinase suppressor, KSR2, and is a component of T cell activation PMID: 23303246
    6. The involvement of KSR2 in regulation of cell proliferation was predicted by a KSR2-centered network analysis. PMID: 21403620
    7. KSR interacts with a regulatory Raf molecule in cis to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf molecule in trans PMID: 21441910
    8. Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia cells. PMID: 20945381
    9. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
    10. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
    11. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    12. hKSR-2, a new member of the KSR family, negatively regulates Cot-mediated MAP kinase and NF-kappaB pathway signaling PMID: 12975377
    13. We find that while hKSR-2 blocks MEKK3 activation, it has little to no effect on other members of the MAP3K family, including MEKK4, TAK1, and Ras-Raf, suggesting that its effects are selective. PMID: 16039990
    14. These results demonstrate that kinase suppressor of Ras 2 is a direct target of 1,25-dihydroxyvitamin D(3)in HL60 cells, and is required for optimal monocytic differentiation. PMID: 17599832
    15. KSR-2 may act as a scaffold protein similar as KSR-1 to mediate the MAPK core (RAF-MEK-ERK) signaling but with a distinct RAF isoform specificity; KSR-2 may only mediate the A-RAF signaling while KSR-1 transduces signals only from c-RAF. PMID: 19563921

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族:
    Protein kinase superfamily, TKL Ser/Thr protein kinase family
  • 組織特異性:
    Mainly expressed in brain and kidney.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 18610

    OMIM: 610737

    KEGG: hsa:283455

    STRING: 9606.ENSP00000339952

    UniGene: Hs.375836



主站蜘蛛池模板: 清纯唯美经典一区二区| 无码av岛国片在线播放| 亚洲日韩中文字幕久热| 国产综合有码无码中文字幕| 亚洲色无码播放| 国产午夜成人免费看片app| 亚洲 中文字幕 日韩 无码| 亚洲五月综合缴情在线| 高潮内射免费看片| 99久久精品国产成人综合| 久久狼人大香伊蕉国产| 国产一区二区三区在线观看免费 | 亚洲精品国产精华液有哪些| 国产免费人成视频在线播放播| 四虎影视在线永久免费观看| 农民人伦一区二区三区| 久久精品国产99国产精偷| 久久天天躁夜夜躁狠狠综合| 久久精品免费一区二区三区| 成人小说亚洲一区二区三区| 少妇性l交大片7724com| 国产免费又色又爽又黄软件| 中文字幕有码无码av| 内射后入在线观看一区| 欧美丰满熟妇xxxxx| 亚洲成年网站青青草原| 久久久久久人妻毛片a片| 野外性史欧美k8播放| 色婷婷综合久久久中文字幕| 美女露出奶头扒开尿口免费网站| 国产日产欧产精品精品ai| 国产成人a在线观看视频| 色悠久久久久久久综合网| 欧美日韩一区二区三区视频播放 | 伊人久久丁香色婷婷啪啪| 中文字字幕在线精品乱码| 日本边添边摸边做边爱| 欧美乱色伦图片区| 国产成人亚洲高清一区| 中国猛少妇色xxxxx| 一本色道久久hezyo无码|