在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KSR2 Antibody

  • 中文名稱:
    KSR2兔多克隆抗體
  • 貨號:
    CSB-PA581207
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from COS7, 293 and 3T3 cells, using KSR2 antibody.
    • Immunofluorescence analysis of HeLa cells, using KSR2 antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) KSR2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from internal of Human KSR2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1. Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
  • 基因功能參考文獻(xiàn):
    1. These observations suggest that, in the brain, KSR2 regulates energy balance via control of feeding behavior and adaptive thermogenesis, while a second KSR2-dependent mechanism, functioning through one or more other tissues, modulates sensitivity to leptin and activators of the energy sensor AMPK. PMID: 28180061
    2. A pleiotropic effect of KSR2-rs7973260 was found on the risk of metabolic syndrome, severe hypertriglyceridemia, and diabetes. PMID: 28537769
    3. KSR2 deficiency affects stromal interaction molecule 1 (STIM1)/ORAI1 puncta formation, which is correlated with cytoskeleton disorganization. PMID: 24672054
    4. Study explored the role of KSR2 in humans by sequencing 2,101 individuals with severe early-onset obesity and identified multiple rare variants in KSR2 that disrupt signaling through the Raf-MEKERK pathway and impair cellular fatty acid oxidation and glucose oxidation in transfected cells. PMID: 24209692
    5. study demonstrated that miR-31 upregulated IL-2 expression via reduction of its up-stream kinase suppressor, KSR2, and is a component of T cell activation PMID: 23303246
    6. The involvement of KSR2 in regulation of cell proliferation was predicted by a KSR2-centered network analysis. PMID: 21403620
    7. KSR interacts with a regulatory Raf molecule in cis to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf molecule in trans PMID: 21441910
    8. Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia cells. PMID: 20945381
    9. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
    10. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
    11. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    12. hKSR-2, a new member of the KSR family, negatively regulates Cot-mediated MAP kinase and NF-kappaB pathway signaling PMID: 12975377
    13. We find that while hKSR-2 blocks MEKK3 activation, it has little to no effect on other members of the MAP3K family, including MEKK4, TAK1, and Ras-Raf, suggesting that its effects are selective. PMID: 16039990
    14. These results demonstrate that kinase suppressor of Ras 2 is a direct target of 1,25-dihydroxyvitamin D(3)in HL60 cells, and is required for optimal monocytic differentiation. PMID: 17599832
    15. KSR-2 may act as a scaffold protein similar as KSR-1 to mediate the MAPK core (RAF-MEK-ERK) signaling but with a distinct RAF isoform specificity; KSR-2 may only mediate the A-RAF signaling while KSR-1 transduces signals only from c-RAF. PMID: 19563921

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族:
    Protein kinase superfamily, TKL Ser/Thr protein kinase family
  • 組織特異性:
    Mainly expressed in brain and kidney.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 18610

    OMIM: 610737

    KEGG: hsa:283455

    STRING: 9606.ENSP00000339952

    UniGene: Hs.375836



主站蜘蛛池模板: 男女作爱免费网站| 亚洲狠亚洲狠亚洲狠狠狠| 300部国产真实乱| 中文成人在线| 精品视频一区二区三区中文字幕| 色综合天天天天综合狠狠爱| 在线 | 国产精品星空传媒丿| 国内最真实的xxxx人伦| 久久96国产精品久久久| 免费现黄频在线观看国产| 久久精品伊人一区二区三区| 狠狠色综合激情丁香五月| 丰满人妻一区二区三区无码av| 伊人久久大香线蕉综合5g| 亲近乱子伦免费视频| 一品二品三品中文字幕| 国产成人免费97在线| 一本大道东京热无码视频| 真人作爱90分钟免费看视频| 菠萝蜜视频在线观看入口 | 少妇把腿扒开让我舔18| 国内少妇偷人精品免费| 国产欧美综合在线观看第十页 | 亚洲香蕉成人av网站在线观看| 国产亚洲高清国产拍精品| 精品av一区二区久久久| 亚洲色成人www永久在线观看| 国产亚洲精品aaaa片app| 亚洲欧美日韩综合久久| 成人免费午夜无码视频| 国产精品无码专区| 国产亚洲日韩在线三区| 国产一卡2卡3卡四卡精品国色无边| 国产av无码专区亚洲版综合| 美女内射毛片在线看免费人动物| 成人午夜高潮刺激免费视频| 嘿咻嘿咻男女免费专区| 天天做天天摸天天爽天天爱| 欧美尺码专线欧洲b1b1| 国产欧美日韩精品专区| 中文字幕无码精品亚洲35|