在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KRT1 Antibody, HRP conjugated

  • 中文名稱:
    KRT1兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA012503LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KRT1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KRT1
  • 別名:
    67 kDa cytokeratin antibody; CK-1 antibody; CK1 antibody; Cytokeratin-1 antibody; Cytokeratin1 antibody; EHK antibody; EHK1 antibody; Epidermolytic hyperkeratosis 1 antibody; EPPK antibody; Hair alpha protein antibody; K1 antibody; K2C1_HUMAN antibody; Keratin antibody; Keratin type II cytoskeletal 1 antibody; Keratin-1 antibody; Keratin1 antibody; KRT 1 antibody; Krt1 antibody; KRT1A antibody; NEPPK antibody; type II cytoskeletal 1 antibody; Type II keratin Kb1 antibody; Type-II keratin Kb1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Keratin, type II cytoskeletal 1 protein (267-438AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.
  • 基因功能參考文獻:
    1. The authors report a large Italian family affected Palmoplantar Keratoderma and Charcot Marie Tooth disease. Two different mutated genes, KRT1 and MPZ were responsible for the two main clinical signs. Exome analysis detected two missense mutations, one in KRT1 and one in MPZ. PMID: 27639257
    2. Results show that missense mutations exert dominant negative effects on the keratins K1/K10 protein structure by altering inter-chain interactions. PMID: 27421141
    3. KRT1 and the specific polymorphism of KRT1 in this Chinese Han population are associated with autoimmune diseases SLE and SSc PMID: 29028840
    4. Case Report: post-zygotic mosaicism of KRT/1o mutations in epidermolytic Ichthyosis. PMID: 27722766
    5. KRT1 played an important role of maintaining epithelial barrier and its down-regulation in intestinal tissue was correlated with the progression of inflammatory bowel disease. PMID: 28111259
    6. Report genetic/clinical spectrum of KRT1 mutations in keratinopathic ichthyosis. PMID: 26581228
    7. demonstrated the presence of a genetic cutaneous mosaicism. Both patients carry the KRT1 pI479T substitution, but in the palmoplantar areas of one of them, only the mutated allele is expressed (hemizygous). This leads to highlight a new type of cutaneous mosaic, the palmoplantar mosaicism PMID: 25904304
    8. In our study, the missense mutation in the proband and his mother with epidermolytic ichthyosis was a single amino acid difference in codon 478, which causes more serious skin manifestations PMID: 25808222
    9. Complete structure of an epithelial keratin 1/keratin 10 dimer has been presented. PMID: 26181054
    10. These findings indicate that exogenous FABP4 interacts with plasma membrane proteins, specifically CK1. PMID: 26343611
    11. analysis of a heterozygous novel splice junction mutation in the 2B domain of KRT1 in a family with diffuse palmoplantar keratoderma PMID: 25429721
    12. In ichthyosis with confetti, a causal de novo KRT1 mutation had a C-terminal frameshift, replacing 22 C-terminal AAs with an alternate 30-AA peptide. It distorted the IF network and mislocalized to the nucleus. Reversion occurred by mitotic recombination. PMID: 25774499
    13. In HeLa cells transiently expressing C2GnT-M-GFP, knockdown of KRT1 does not affect Golgi morphology but leaves C2GnT-M outside of the Golgi, resulting in the formation of sialyl-T antigen. PMID: 25605727
    14. Decreased levels of cytokeratin-1 is associated with breast cancer. PMID: 25073515
    15. Hsp74, a potential bladder cancer marker, has direct interaction with keratin 1. PMID: 25050384
    16. identified among endothelial antigens to which antibodies are produced during heart transplant rejection PMID: 23707440
    17. Case Report/Letter: specific mutation in 2B domain of KRT1 gives rise to mild phenotype of epidermolytic hyperkeratosis mimicking ichthyosis bullosa of Siemens. PMID: 23623204
    18. study reports 2 related women of Colombian origin, affected by a severe ichthyosis curth-macklin phenotype, who present a novel KRT1 mutation c.1577delG (p.Gly526Alafs*88) PMID: 22834809
    19. Absence of Krt1 caused a prenatal increase in interleukin-18 (IL-18) and the S100A8 and S100A9 proteins, accompanied by a barrier defect and perinatal lethality. PMID: 23132931
    20. Among Japanese patients with bullous congenital ichthyosiform erythroderma for which genetic diagnosis was determined, all showed mustations in KRT1 or KRT10. PMID: 23182068
    21. Identification Keratin 1 as a cDDP-resistant protein in nasopharyngeal carcinoma cell lines. PMID: 22348822
    22. High cytokeratin is associated with colorectal carcinogenesis. PMID: 21912905
    23. we describe one Chinese family affected with EHK, type PS-1 (severe palmoplantar hyperkeratosis, type 1) and report a recurrent missense mutation (c.1436T>C) in the 2B rod domain of KRT1 in this family. PMID: 22250628
    24. mutation analysis in patients with epidermolytic ichthyosis by direct sequencing of KRT1 and KRT10 genes; identified 14 different mutations, of which four have not been published previously PMID: 21271994
    25. keratin 1 L12 domain mutations are associated with a milder epidermolytic ichthyosis phenotype with pronounced palmoplantar keratoderma, and without neonatal erythroderma and scaling. PMID: 20500210
    26. Data demonstrate that genetic variants in the KRT1 interval contribute to quantifiable differences in the migration rates of keratinocytes isolated from different individuals. PMID: 17668073
    27. alpha-keratin intermediate filaments have a low-density core as seen by cryoelectron microscopy PMID: 12064938
    28. The humans hair Keratin 1 genes are each clustered in the genome and clusters are part of the large typeI epithelial keratin gene domains on chromosomes. PMID: 15797458
    29. bullous congenital ichthyosiform erythroderma (BCIE) caused by a mutation in the 1A helix initiation motif of keratin 1. PMID: 16361731
    30. A new genetic polymorphism has been detected, which is especially prevalent among the African-American population. PMID: 16417221
    31. Allelic expression differences result from the cumulative contribution of multiple DNA sequence polymorphisms. PMID: 16789827
    32. The 2 keratin 1 mutations are associated with tonotubular keratin, i.e. 'whorls' of aggregated keratin that form tubules as seen in transverse or in longitudinal sections PMID: 18795921
    33. Mutation L437P in the 2B domain of keratin 1 causes diffuse palmoplantar keratoderma in a Chinese pedigree. PMID: 19470048
    34. Keratin 1, an intermediate filament network component, is the binding partner of the lymphocytic choriomeningitis virus nucleoprotein. PMID: 19494018
    35. Infection by HPV may alter the differentiation status of the epidermis, leading to delayed or absent expression of cytokeratin 1. PMID: 19515043

    顯示更多

    收起更多

  • 相關疾病:
    Epidermolytic hyperkeratosis (EHK); Ichthyosis hystrix, Curth-Macklin type (IHCM); Keratoderma, palmoplantar, non-epidermolytic (NEPPK); Ichthyosis annular epidermolytic (AEI); Keratoderma, palmoplantar, striate 3 (SPPK3)
  • 亞細胞定位:
    Cell membrane. Note=Located on plasma membrane of neuroblastoma NMB7 cells.
  • 蛋白家族:
    Intermediate filament family
  • 組織特異性:
    The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis.
  • 數據庫鏈接:

    HGNC: 6412

    OMIM: 113800

    KEGG: hsa:3848

    STRING: 9606.ENSP00000252244

    UniGene: Hs.80828



主站蜘蛛池模板: 久久99亚洲精品久久69| 在线亚洲高清揄拍自拍一品区 | 国产激情久久久久影院老熟女| 男女真人国产牲交a做片野外| 色视频无码专区在线观看| 国产精品久久人妻无码| 精品国产aⅴ无码一区二区| 久久96国产精品久久久| 最新国产久免费视频在线观看| 中文字幕丝袜第1页| 18禁肉肉无遮挡无码网站| 国产超碰人人爱被ios解锁| 国产麻豆精品精东影业av网站| 久久精品成人亚洲另类欧美| 国产suv精品一区| 欧洲免费无线码在线一区| 日本高清不卡aⅴ免费网站| 性一交一乱一乱一视频| 国产69精品久久久久久久| 久久综合九色综合欧美婷婷| 久久精品女同亚洲女同| 精品午夜福利无人区乱码一区| 日韩 无码 偷拍 中文字幕| 最近日本mv字幕免费高清完整版| 99国精品午夜福利视频不卡 | 国产亚洲欧美日韩俺去了| 国产精品xxx在线| 碰超免费人妻中文字幕| 久久久肥妇熟女ⅹxxx毛片| 性欧美大战久久久久久久久 | 日本一卡二卡3卡四卡网站精品 | 熟妇人妻av无码一区二区三区 | 日本高清无卡码一区二区久久| 国产福利日本一区二区三区| 亚洲精品中文字幕一区二区三区| 少妇高潮喷水久久久影院| 亚洲午夜久久久久妓女影院| 精品美女国产互换人妻| 性视频播放免费视频| 亚洲熟妇无码av另类vr影视| 国产精品区一区二区三在线播放|