在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. KMT2E Antibody

KMT2E Antibody

  • 中文名稱：
    KMT2E兔多克隆抗體
  • 貨號：
    CSB-PA818269LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, SH-SY5Y whole cell lysate, NIH/3T3 whole cell lysate, 293T whole cell lysate, MCF-7 whole cell lysate, K562 whole cell lysate
      All lanes: KMT2E antibody at 3.1μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 205, 196, 69, 99, 186, 181, 201, 132 kDa
      Observed band size: 80 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) KMT2E Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KMT2E
  • 別名：
    HDCMC04P antibody; Histone lysine N methyltransferase MLL5 antibody; Histone-lysine N-methyltransferase MLL5 antibody; KMT2E antibody; Lysine N methyltransferase 2E antibody; Lysine N-methyltransferase 2E antibody; MGC70452 antibody; Mll5 antibody; MLL5_HUMAN antibody; Myeloid/lymphoid or mixed lineage leukemia 5 (trithorax homolog; Drosophila) antibody; Myeloid/lymphoid or mixed lineage leukemia 5 antibody; Myeloid/lymphoid or mixed lineage leukemia protein 5 antibody; Myeloid/lymphoid or mixed-lineage leukemia protein 5 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Histone-lysine N-methyltransferase 2E protein (182-316AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，KMT2E Antibody (CSB-PA818269LA01HU)，的標記方式是Non-conjugated。對于KMT2E Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA818269LB01HU KMT2E Antibody, HRP conjugated ELISA
    FITC CSB-PA818269LC01HU KMT2E Antibody, FITC conjugated
    Biotin CSB-PA818269LD01HU KMT2E Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry. Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition. During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells.; Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity.
  • 基因功能參考文獻：
    1. three dimensional structure of MLL5 SET domain unveils the structural basis for its lack of methyltransferase activity PMID: 27812132
    2. MLL5 preserves spindle bipolarity through maintaining cytosolic PLK1 in a nonaggregated form. PMID: 27002166
    3. MLL5 interacts with OGT and USP7 to form a stable ternary complex. Upregulation of MLL5 expression was correlated with increased expression of OGT and USP7 in human primary cervical adenocarcinomas. PMID: 26678539
    4. Suggest a role for MLL5 and H3.3 in maintaining self-renewal hierarchies in adult glioblastomas. PMID: 26626085
    5. O-GlcNAcylation of MLL5beta at T440 residue is critical for MLL5 recruitment to the HPV16/18-long control region through its interaction with AP-1. PMID: 25670814
    6. Improved outcome is observed in decitabine-treated patients who express MLL5 at high levels. PMID: 24895338
    7. KMT2E expression retained association with poor acute promyelocytic leukaemia remission rate and shorter survival while the association with disease-free survival was of marginal significance. PMID: 24796963
    8. NMR solution structure of the MLL5 PHD domain PMID: 24130829
    9. these results indicate that the suppression of MLL genes, especially MLL2 and MLL5, take part in modulating breast carcinogenesis. PMID: 23754336
    10. MLL5 is a cellular ligand for the natural cytotoxicity receptor NKp44. PMID: 23958951
    11. findings provide first insights into the molecular basis for the recruitment, exclusion, and regulation of MLL5 at chromatin PMID: 23798402
    12. MLL5 can associate with HCF-1 and then be recruited to E2F1-responsive promoters to stimulate H3K4 trimethylation and transcriptional activation. PMID: 23629655
    13. A new isoform, MLL5beta, truncated in exon 14, regulates E6 & E7 transcription in cervical carcinoma cells. Interaction of MLL5beta with the AP-1-binding site at the distal region of the HPV18 long control region activated E6/E7 transcription. PMID: 21908553
    14. High MLL5 expression levels are associated with a favorable outcome and may improve risk and treatment stratification in acute myeloid leukemia PMID: 21205756
    15. Phosphorylation of MLL5 may have an indispensable role in the mitotic progression in mixed lineage leukemia cells. PMID: 20439461
    16. MLL5 forms intranuclear protein complexes that may play an important role in chromatin remodeling and cellular growth suppression. PMID: 14718661
    17. These findings provide evidence that MLL5 might be an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. PMID: 18573682
    18. MLL5 protein has been classified into a distinct subfamily with SETD5, because its SET domain and domain architecture show high homology with SETD5 rather than the members in MLL subfamily (i.e. MLL, MLL2, MLL3 and MLL4) PMID: 18231586
    19. MLL5 is a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia. PMID: 12101424

    顯示更多

    收起更多

  • 亞細胞定位：
    Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus speckle.; [Isoform 3]: Nucleus, nucleoplasm. Nucleus speckle.; [Isoform NKp44L]: Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, TRX/MLL subfamily
  • 組織特異性：
    Widely expressed in both adult and fetal tissues. Highest levels of expression observed in fetal thymus and kidney and in adult hematopoietic tissues, jejunum and cerebellum. Isoform NKp44L: Not detected on circulating cells from healthy individuals, but
  • 數據庫鏈接：

    HGNC: 18541

    OMIM: 608444

    KEGG: hsa:55904

    STRING: 9606.ENSP00000257745

    UniGene: Hs.592262



主站蜘蛛池模板： 宝宝好涨水快流出来免费视频| 又色又爽又黄的gif动态图| 亚洲人成电影网站色| 亚洲成本人无码薄码区| 欧美日韩视频在线第一区 | 无码啪啪熟妇人妻区| 精品一区二区三区四区五区六区| 天天综合色天天综合色hd| 色88久久久久高潮综合影院| 国产精品免费久久久久影院仙踪林| 国产精品无码久久av| 欲香欲色天天天综合和网| 国产亚洲产品影视在线产品| 久久国产午夜精品理论片34页| 久久精品一区二区av999| 亚洲精品无码国产片| 国产精品一卡二卡三卡| 亚拍精品一区二区三区探花| 免费啪视频在线观看视频网页| 国产成人av男人的天堂| 强睡邻居人妻中文字幕| 国产成人麻豆精品午夜福利在线| 亚洲a∨精品永久无码| 无码一区二区免费波多野播放搜索| 小泽玛利亚一区二区在线观看| 中国女人内谢69xxxxxa片| 日韩国产亚洲欧美中国v| 99久久99视频只有精品| 精品无码专区毛片| 成 人影片 免费观看| 伊人久久丁香色婷婷啪啪| 日日摸处处碰夜夜爽| 成 年 人 黄 色 大 片大 全| 亚欧免费无码aⅴ在线观看蜜桃| 欧美黑人性暴力猛交喷水| 欧美中日韩免费观看网站| 亚洲国产精品成人久久| 3p人妻少妇对白精彩视频| 国产sp调教打屁股视频网站| 性高朝久久久久久久| 免费三级现频在线观看免费|