在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KMO Antibody

  • 中文名稱:
    KMO兔多克隆抗體
  • 貨號(hào):
    CSB-PA012475ESR1HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: KMO antibody at 10μg/ml + Mouse heart tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 56, 55, 52 kDa
      Observed band size: 56 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA012475ESR1HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) KMO Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KMO
  • 別名:
    dJ317G22.1 antibody; kmo antibody; KMO_HUMAN antibody; Kynurenine 3 hydroxylase antibody; Kynurenine 3 monooxygenase (kynurenine 3 hydroxylase) antibody; Kynurenine 3 monooxygenase antibody; Kynurenine 3-hydroxylase antibody; Kynurenine 3-monooxygenase antibody; RP1-317G22.1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Kynurenine 3-monooxygenase protein (1-260AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable).
  • 基因功能參考文獻(xiàn):
    1. There is the association between the rs1053230 polymorphism and depression. PMID: 28139632
    2. results show the incidence of Postpartum Depression in the Chinese population to be 7.3%, with PDS characterized by increased serum 3-HydroxyKinurenine concentration and 3-HK/Kynurenine ratio, versus matched postpartum women without PDS. Furthermore, polymorphisms of Kynurenine Monooxygenase rs1053230 are significantly associated with the incidence of PDS. PMID: 28319697
    3. Our data establish the candidacy of KMO as a causal factor for changes in the kidney leading to proteinuria and indicate a functional role for KMO and metabolites of the tryptophan pathway in podocytes PMID: 27020856
    4. A comprehensive review of the molecular properties of KMO, including its kinetics, reaction mechanism, and inhibitor structure-activity relationship (SAR), is not currently available and, thus, is our focus here PMID: 26589832
    5. SiRNA knockdown of the pathway components Kynurenine 3-monooxygenase and quinolinate phosphoribosyl transferase caused cells to revert to a state of susceptibility to 3HK-mediated apoptosis. PMID: 27077813
    6. These results suggest that KMO exhibits tumor-promoting effects towards hepatocellular carcinoma (HCC) and it may serve as a novel prognostic marker in HCC. PMID: 26099564
    7. Results suggest that KMO variation influences a range of cognitive domains known to predict functional outcome in schizophrenia PMID: 25464917
    8. Two KMO SNPs were observed more often in schizophrenia patient group compared with healthy controls. PMID: 25715464
    9. findings from five independent cohorts suggest that genetic variation in KMO influences the risk for psychotic features in mania of bipolar disorder patients. PMID: 23459468
    10. Study reporting on the first successful bacterial (Escherichia coli) expression of active FLAGtrade mark-tagged human KMO enzyme expressed in the soluble fraction and progress towards its purification. PMID: 24316190
    11. analyzed association between KMO gene polymorphisms and CSF concentrations of kynurenic acid in patients with schizophrenia and controls. results suggest that the nonsynonymous KMO SNP rs1053230 influences CSF concentrations of KYNA. PMID: 21693093
    12. significant and correlated reduction in gene expression and enzyme activity in the frontal eye field in schizophrenia patients; rs2275163 has modest effects on predictive pursuit and visuospatial working memory endophenotypes PMID: 21727251
    13. The present analysis of the combined Scandinavian sample did not reveal any allele frequency difference between patients and healthy controls PMID: 21030213
    14. the function KMO AND indoleamine 2,3-dioxygenase may change from a role in immunosuppression at the maternal-fetal interface in early pregnancy, to one associated with regulation of fetoplacental blood flow or placental metabolism in late gestation PMID: 15950064
    15. Results suggest that kynurenine 3-monooxygenase is unlikely to be related to the development of schizophrenia in Japanese. PMID: 16716206

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Mitochondrion outer membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Aromatic-ring hydroxylase family, KMO subfamily
  • 組織特異性:
    Highest levels in placenta and liver. Detectable in kidney.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6381

    OMIM: 603538

    KEGG: hsa:8564

    STRING: 9606.ENSP00000355517

    UniGene: Hs.731056



主站蜘蛛池模板: 99久久99久久久精品齐齐| 亚洲中文字幕不卡无码| 秋霞国产精品一区二区| 国产无遮挡a片无码免费软件| 99热这里只有精品免费播放| 88国产精品欧美一区二区三区| 久天啪天天久久99久久| 亚洲 制服 丝袜 无码 在线| 波多野结衣一区二区三区av高清| 国模无码一区二区三区| 夜色约爱网站| 亚洲欧美综合精品成人网站| 337p日本欧洲亚洲大胆裸体艺术| 97影院理论片手机在线观看| 久久亚洲精品中文字幕一区| 717影院理论午夜伦八戒| 日韩人妻无码一区二区三区| 国产精品亚洲综合一区在线观看| aaa欧美色吧激情视频| 蜜桃av噜噜一区二区三区| 香蕉久久福利院| 妺妺跟我一起洗澡没忍住| 亚洲 欧美 动漫 少妇 自拍| 亚洲aⅴ男人的天堂在线观看| 成人国产欧美大片一区| 国产成人无码午夜福利在线直播| 亚洲欧美日韩综合久久久久久| 国产成人一区二区三区影院动漫| 亚洲 欧美 成人 自拍 高清| 中文字幕精品久久久久人妻红杏| 麻豆国产一区二区三区四区| 全黄激性性视频| 国产亚洲一区二区在线观看| 久久亚洲人成综合网| 国产一卡2卡3卡四卡精品app| 99久热re在线精品99 6热视频| 西西人体大胆午夜啪啪| 欧产日产国产精品| 亚洲 欧美 综合 另类 中字| 亚洲精品国产精品乱码不99| 超caopor在线公开视频|