在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KLRG1 Antibody

Unavailable
  • 中文名稱:
    KLRG1兔多克隆抗體
  • 貨號:
    CSB-PA012472GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    2F1 Ag antibody; 2F1 antibody; C type lectin domain family 15 member A antibody; C-type lectin domain family 15 member A antibody; CLEC15A antibody; ITIM containing receptor MAFA L antibody; ITIM-containing receptor MAFA-L antibody; Killer cell lectin like receptor G1 antibody; Killer cell lectin like receptor subfamily G member 1 antibody; Killer cell lectin-like receptor subfamily G member 1 antibody; KLRG 1 antibody; KLRG1 antibody; KLRG1 protein antibody; KLRG1_HUMAN antibody; MAFA 2F1 antibody; MAFA antibody; MAFA L antibody; MAFA like antibody; MAFA like receptor antibody; MAFA-like receptor antibody; MAFAL antibody; Mast cell function associated antigen (ITIM containing) antibody; Mast cell function associated antigen antibody; Mast cell function-associated antigen 2F1 antibody; Mast cell function-associated antigen antibody; Mast cell function-associated antigen, rat, homolog of antibody; MGC13600 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human KLRG1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.
  • 基因功能參考文獻:
    1. KLRG1 might contribute to the impaired antitumor immunity of memory T cells in tumor microenvironment PMID: 27557510
    2. Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5'-Monophosphate-Activated Protein Kinase PMID: 27566818
    3. The results suggest that a disease-associated SNP located within the 3'UTR of KLRG1 directly interferes with miR-584-5p binding, allowing for KLRG1 mRNA differential accumulation, which in turn may contribute to pathogenesis of pemphigus. PMID: 27424220
    4. Demonstrate the presence of increased KLRG1-expressing T-cells in tuberculosis-treated individuals, and present KLRG1 as a marker of decreased human T-cell proliferation following BCG-vaccination. PMID: 26750180
    5. This finding provides a rationale for the reciprocal expression of KLRG1 and CD103 in different CD8(+) T-cell subsets. PMID: 26014037
    6. high levels of TfRs such as those found on activated lymphocytes were found to be associated with decreased KLRG1 inhibitory function, indicating that TfRs may sequester KLRG1 from interacting with cadherins. PMID: 24752778
    7. More T cells were KLRG1+ in the synovial fluid of patients with spondylarthritis/rheumatoid arthritis than crystal arthritis or controls. Those T cells were more functionally active, and migrated towards the synovial fluid of SpA/RA patients. PMID: 23740233
    8. KLRG1 was overexpressed on CD4(+) T cells. PMID: 24337749
    9. Data indicate that increments of CD8 + effector memory T cells in human and mouse chronic lymphocytic leukemia (CLL)(Emu-TCL1 model) were due to an expansion of the inhibitory killer cell lectin-like receptor G1 (KLRG1) expressing cellular subset. PMID: 24022692
    10. These results indicate that KLRG1 negatively regulates natural killer cell numbers and functions via the Akt pathway, thus providing a novel marker and therapeutic target for hepatitis C virus infection. PMID: 23966413
    11. The lower inhibitory capacity of mKLRG1 compared with hKLRG1 can thus be rationalized by a decreased proportion of dimeric entities, which can be pinpointed to a single amino acid. PMID: 22684915
    12. cytomegalovirus positive had lower proportions of NK-cells expressing inhibitory receptors (KLRG1 and CD158a) PMID: 21933704
    13. trastuzumab-mediated antibody-dependent cellular cytotoxicity was markedly enhanced by KLRG1-negative peripheral blood mononuclear cells PMID: 21387286
    14. Results demonstrated a substantial reduction in both CD94- and KLRG1- expressing CD3(-)CD56(+) NK cells with increased age. PMID: 20394788
    15. Expression of MafA analyzed in conditional knockout mice during embryonic development is the first specific marker of a subpopulation of "early c-ret" positive sensory neurons. PMID: 20213756
    16. human effector and memory T cells expressing KLRG1 lack proliferative capacity PMID: 12393723
    17. KLRG1 expression discriminated between cord blood T cells that differed in their post-thymic expansion rate PMID: 15368283
    18. KLRG1 is expressed in the overwhelming majority of CD8-positive T cells specific for epitopes of cytomegalovirus or Epstein- Barr virus during the latent stage; a slightly lower KLRG1 expression level is observed in HIV-specific T8 cells. PMID: 15879103
    19. virus-specific CD8+ T cells are mostly KLRG1+ in chronic viral infections (human immunodeficiency virus, cytomegalovirus, and Epstein-Barr virus) but not in resolved infection (influenza virus) PMID: 16140789
    20. peripheral HCV-specific CD8+ T cells were CD127+ and KLRG1-; Intrahepatic virus-specific CD8+ T cells displayed significantly reduced levels of CD127 expression but similar levels of KLRG1 expression compared to the peripheral blood. PMID: 17079288
    21. study demonstrates that E-cadherin represents a ligand for KLRG1 and that ligation of KLRG1 by E-cadherin inhibited effector cell functions of polyclonal NK cells PMID: 17617594
    22. Certain aspects of the dysfunction seen in highly differentiated CD8+ T cells are maintained actively by KLRG1 signaling. KLRG1 blockade enhances Akt (ser(473)) phosphorylation & T-cell-receptor-induced proliferation of CD8+CD28-CD27- T cells. PMID: 19406987
    23. E-cadherin may coengage KLRG1 and alpha(E)beta(7) and that KLRG1 overcomes its exceptionally weak affinity for cadherins through multipoint attachment to target cells, resulting in inhibitory signaling. PMID: 19604491

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type II membrane protein.
  • 組織特異性:
    Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6380

    OMIM: 604874

    KEGG: hsa:10219

    STRING: 9606.ENSP00000349477

    UniGene: Hs.558446



主站蜘蛛池模板: 国内精品久久久久影院免费| 男人女人做爽爽18禁网站| 亚洲成年轻人电影网站www| 亚洲精品中文字幕| 亚洲精品国产a久久久久久| 东北妇女精品bbwbbw| 午夜福利麻豆国产精品| 无码av岛国片在线播放| 东京热无码国产精品| 国产日韩av免费无码一区二区三区 | 亚洲国产精品久久久久秋霞影院| 国产精品久久精品国产| 日本一二免费不卡区| 国产精品毛片在线完整版| 2018天天拍拍天天爽视频| 亚洲五月天综合| 中文字幕乱码免费看电影| 四虎成人精品无码永久在线| 麻豆熟妇人妻xxxxxx| 久久www成人片免费看 | 精品无码一区在线观看| 欧美亚洲精品一区二区| 四川丰满妇女毛片四川话| 宅男666在线永久免费观看| 狠狠色噜噜狠狠狠狠蜜桃| 国产1卡2卡三卡四卡精品| 亚洲国产一区二区三区波多野结衣 | 国产suv精品一区二人妻| 自慰系列无码专区| 亚洲精品无码高潮喷水a片软| 三级网站视频在在线播放| 苍井空浴缸大战猛男120分钟| 国产成人无码免费视频在线| 色视频无码专区在线观看| a在线观看免费网站大全| 欧美成年视频在线观看| 久久精品亚洲精品国产色婷| 最新 国产 精品 精品 视频| 天天夜碰日日摸日日澡性色av| 成人性生交片无码免费看| 国产真实偷乱视频|