在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KLK7 Antibody

  • 中文名稱:
    KLK7兔多克隆抗體
  • 貨號:
    CSB-PA094965
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA094965(KLK7 Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA094965(KLK7 Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Chymotryptic stratum corneum antibody; hK 7 antibody; hK7 antibody; hSCCE antibody; Kallikrein 7 (chymotryptic stratum corneum) antibody; Kallikrein related peptidase 7 antibody; Kallikrein-7 antibody; Kallikrein7 antibody; KLK 7 antibody; Klk7 antibody; KLK7_HUMAN antibody; Protease serine 6 antibody; PRSS 6 antibody; PRSS6 antibody; SCCE antibody; Serine protease 6 antibody; Signal protein antibody; Stratum corneum chymotryptic enzyme antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Fusion protein of Human KLK7
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
  • 基因功能參考文獻:
    1. These results show that aberrant KLK7 expression leads to a switch from proliferative to invasive phenotype, suggesting a potential role of KLK7 in melanoma progression. PMID: 28636767
    2. KLK7 is differentially expressed in lesional biopsy specimens from patients with atopic eczema relative to normal skin PMID: 28479159
    3. impaired KLK7 secretion from lamellar granules and increased LEKTI expression could underlie the insufficient activation of KLK in atopic dermatitis. PMID: 27769847
    4. Epigenetic regulation of KLK7 gene expression in pancreatic and cervical cancer cells PMID: 27279059
    5. Korean X-linked ichthyosis patients exhibited unimpaired skin barrier function and frequent association with the KLK7 gene polymorphism, which may differentiate them from Western X-linked ichthyosis patients. PMID: 27478344
    6. This report demonstrates that concurrent loss of KLK5 and KLK7 associates with a poor clinical outcome in Squamous-Cell Carcinoma and could therefore serve as prognostic marker in this disease. PMID: 26022646
    7. Data demonstrate that elevated levels of KLK6, KLK7 and KLK9 proteins are associated with poor glioblastoma patients survival. PMID: 26231762
    8. Our findings suggest that serum KLK7 may be a valuable diagnostic biomarker for cervical cancer, and may help to determine the individual prognosis of these patients. PMID: 25182706
    9. KLK6 and KLK7 mRNA and protein overexpression is directly associated with early-stage ovarian tumors. PMID: 25477184
    10. Proteolytic cleavage of midkine, CYR61, and tenascin-C govern the pathophysiological roles of KLK7. PMID: 26032414
    11. Early-stage oral squamous cell carcinoma and high KLK7 mRNA levels were correlated with the rs10581213(wt/ins + ins/ins) genotypes PMID: 23413953
    12. These results demonstrate the aberrant expression of KLK7 in colon cancer cells and tissues and its involvement in cell proliferation in vitro and in vivo. PMID: 25153388
    13. Daata indicate that the peptide Abz-NLY( downward arrow)RVE-Q-EDDnp is the best synthetic substrate for Kallikrein-related peptidase 7 (KLK7) [kcat/Km=455 (mMs)(-1)]. PMID: 25448018
    14. KLK7 and KLK14 gene expression can be regarded as markers of poor prognosis for colorectal cancer patients with discriminating power between CC and adenoma patients. PMID: 23224034
    15. Prochemerin processing protease converts prochemerin into active chemerinF; the activating truncation by the protease may trigger a structural C-terminal rearrangement leading to increased affinity of chemerin to chemokine-like receptor (CMKLR)1. PMID: 23495698
    16. High KLK7 expression is associated with pancreatic ductal adenocarcinoma. PMID: 22573795
    17. regulation of procaspase-14 maturation during terminal differentiation is a unique two-step process involving KLK7 and an activation intermediate of caspase-14. PMID: 22825846
    18. The enhancement of protease activity through increased KLK7 expression by the TH2 cytokines IL-4 and IL-13 might be an important factor for mechanical and chemical epidermal barrier dysfunction in patients with atopic dermatitis. PMID: 22521249
    19. Stromal cells can suppress the expression of the KLK7 gene in the epithelial cells in benign prostate hyperplasia. PMID: 21548205
    20. Significant co-expression of KLKs 5 and 7 was observed in the same cancer samples. Increased KLK5 expression was a statistically significant independent prognostic factor for DFS and OS of patients PMID: 21868565
    21. Both KLK7 (P=0.026) and KLK11 (P<0.001) expressions were decreased in prostate cancer cells compared to normal/benign prostate cells PMID: 21520985
    22. KLK7 may play an important role in the activation of MMP-9 in tumors that express high levels of both these proteases PMID: 21616098
    23. Our evidence suggests that the AACCins5874 insertion in the 3'untranslated region of the SCCE gene causes an over-expression in COS-7 and HeLa cells but does not have an effect on mRNA stability. PMID: 21168996
    24. in the high-KLK7-expression group there was more progressive liver metastasis and more advanced clinical staging compared with the low-KLK7-expression group PMID: 20544292
    25. hK7 plays an important role in mediating prostate cancer progression PMID: 20944116
    26. Overexpression of kallikrein 7 is associated with cervical neoplasia. PMID: 19921697
    27. expression and activity of KLK are under fine control and can be distinctly influenced by variables such as differentiation, calcium, vitamin D, and retinoic acid PMID: 20090765
    28. High expression of KLK7 transcript with a long 3'-untranslated region is associated with ovarian cancer PMID: 12738725
    29. human kallikrein 7 may have a role in breast carcnoma PMID: 14691584
    30. Among all kallikreins measured, detectable levels in cerebrospinal fluid are identified for kallikrein K7. The most notable difference is seen between controls and frontotemperol dementia patients and controls and Alzheimer patients. PMID: 14972646
    31. SCCE directly cleaved corneodesmosin and desmocollin 1 but was unable to degrade desmoglein 1. PMID: 15140227
    32. The AACC insertion in the SCCE gene may result in a change to SCCE activity within the skin barrier so SCCE could have an important role in the development of atopic dermatitis. PMID: 15191543
    33. Squamous cervical cancer expressed high levels of SCCE, suggesting that this protease may play an important role in invasion and metastasis. PMID: 15297163
    34. in normal skin the LG system transports and secretes LEKTI earlier than KLK7 and KLK5 preventing premature loss of stratum corneum integrity/cohesion. PMID: 15675955
    35. variability in KLK5 and KLK7 gene expression might be involved in lung tumorigenesis PMID: 15766562
    36. in majority of patients with Netherton syndrome, Dsg1 & Dsc1 were reduced in living layers of epidermis; SCTE-like & SCCE-like activities were increased, suggesting these proteases participate in premature degradation of corneodesmosomal cadherins PMID: 16628198
    37. KLK5 and KLK7 were shown to control activation of CAP18 and also influence further processing to smaller peptides with alternate biological activity; the balance of proteolytic activity at an epithelial interface will control innate immune defense PMID: 17012259
    38. x-ray structures of recombinant active K7 at medium and atomic resolution PMID: 17909180
    39. in 99 children and adults with atopic dermatitis found that an association with KLK7 4bp insertion polymorphism was not confirmed. PMID: 17989887
    40. predominant localisation of KLK5 and KLK7 in acinar cells of the exocrine pancreas; KLK5 and KLK7 generate transcripts in pancreas variant from those in skin or ovary PMID: 18163887
    41. Expression of KLK7, a novel biomarker for advanced ovarian carcinoma, was determined by a novel in situ quantitative method. PMID: 18325919
    42. Data show that hK7 was crystallized, and its three-dimensional structure was solved in the absence of protease inhibitors. A model of the interaction between the protease and its inhibitor is proposed. PMID: 18329042
    43. KLK7 is able to cleave fibronectin in a time-dependent manner, but not laminin. PMID: 18343220
    44. KLK7 insertion appears to confer no risk of eczema; no interaction between the SPINK5 risk allele or the putative KLK7 risk allele and FLG mutations was found PMID: 18774391
    45. Expression of kallikrein 7 diminishes pancreatic cancer cell adhesion to vitronectin and enhances urokinase-type plasminogen activator receptor shedding. PMID: 18953252
    46. hK7 and ALP were decreased in malignant prostate epithelium. PMID: 18976018
    47. kallikreins 5, 7, 8, and 10 are abundantly expressed in human OSCC and may be implicated in malignant progression PMID: 19085836
    48. expression of K7 in BxPC-3 cells resulted in increase in shedding of soluble desmoglein 2 consistent with notion that aberrant expression of K7 in pancreatic tumors may result in diminished cell adhesion & facilitate tumor cell invasion PMID: 19091121
    49. reduced expression of LEKTI and increased expression of SCCE and SCTE in human epidermal keratinocytes after UVB irradiation may contribute to desquamation of the stratum corneum. PMID: 19118981
    50. Data suggest that KLK7 gene is up-regulated in colon cancer and its expression predicts poor prognosis for colon cancer patients. PMID: 19350120

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.
  • 蛋白家族:
    Peptidase S1 family, Kallikrein subfamily
  • 組織特異性:
    Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up
  • 數據庫鏈接:

    HGNC: 6368

    OMIM: 604438

    KEGG: hsa:5650

    STRING: 9606.ENSP00000375683

    UniGene: Hs.151254



主站蜘蛛池模板: 激情综合婷婷丁香五月蜜桃| 影音先锋人妻av中文字幕久久| 亚洲欧美人成网站在线观看看| 综合自拍亚洲综合图区高清| 欧美人与动牲猛交a欧美精品 | 99久久综合狠狠综合久久| 久久激情日本亚洲欧洲国产中文| 亚洲成aⅴ人最新无码| 国产乱妇无码大片在线观看| 久久五月精品中文字幕| 欧美网站免费观看在线| 日韩国产精品人妻无码久久久| 好紧好湿好黄的视频| 野狼av午夜福利在线| 日日碰狠狠躁久久躁2023| 中文字字幕在线乱码视频| 国产真人做爰视频免费| 狠狠色综合网丁香五月| 黄网站色视频免费国产| 天堂www中文资源| 国产成人精品电影在线观看| 欧洲熟妇牲交| 久久亚洲精品国产精品婷婷| 亚洲色国产欧美日韩| 亚洲午夜未满十八勿入网站| 国产人妻久久精品二区三区特黄 | 性做久久久久久久久| 51久久成人国产精品麻豆| 一本精品99久久精品77| 国产精品嫩草影院入口一二三| 色一情一乱一伦| 日韩人妻熟女中文字幕aⅴ春菜| 成人a毛片视频免费看| 性色av无码不卡中文字幕| 蜜臀av色欲a片无码精品一区| 电影久久久久久| 色诱久久久久综合网ywww| 国产艳妇av在线观看果冻传媒| 亚洲精品久久久久久久观小说| 天天影视性色香欲综合网| 成熟丰满熟妇高潮xxxxx|