在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KLK10 Antibody

  • 中文名稱:
    KLK10兔多克隆抗體
  • 貨號:
    CSB-PA012447ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA012447ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA012447ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KLK10 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KLK10
  • 別名:
    Breast normal epithelial cell associated serine protease antibody; Kallikrein related peptidase 10 antibody; Kallikrein-10 antibody; Kallikrein10 antibody; KLK 10 antibody; KLK10 antibody; KLK10_HUMAN antibody; NES 1 antibody; NES1 antibody; Normal epithelial cell specific 1 antibody; Normal epithelial cell-specific 1 antibody; Protease serine like 1 antibody; Protease serine-like 1 antibody; PRSS L1 antibody; PRSSL 1 antibody; PRSSL1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Kallikrein-10 protein (35-276AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Has a tumor-suppressor role for NES1 in breast and prostate cancer.
  • 基因功能參考文獻:
    1. MiR-199b-5p promotes cell proliferation, migration and suppresses apoptosis in cervical cancer cells. KLK10 is a direct target of miR-199b-5p. MiR-199b-5p expression is increased and positively correlated with KI-67 in human cervical cancer tissues and cell lines. PMID: 29807015
    2. blockade of KLK10 attenuates epithelial-mesenchymal transition and activation of FAK-SRC-ERK signaling, which explains the mechanism of KLK10 in promoting metastasis. PMID: 29621546
    3. To the best of our knowledge, this is the first report on KLK10 exon 3 unmethylated PCR product concentration as potential early epigenetic diagnostic marker in primary ovarian tumors. PMID: 29690914
    4. KLK10 was verified to be a potential therapeutic target for reversing trastuzumab resistance in breast cancer cells. PMID: 27825132
    5. Pronounced correlations between KLK10/KLK11 (rs = 0.647) and between KLK9/KLK15 (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases PMID: 29095848
    6. identification and molecular cloning of eight novel transcripts of the human KLK10 gene using 3' rapid amplification of cDNA ends (3' RACE) and next-generation sequencing (NGS), as well as their expression analysis in a wide panel of cell lines, originating from several distinct cancerous and normal tissues PMID: 28419837
    7. Data suggest that mature KLK9 (kallikrein 9) is a glycosylated chymotrypsin-like enzyme with strong preference for tyrosine over phenylalanine at P1 cleavage position; substrate specificity of KLK9 appears to extend to KLK10 and midkine; enzyme activity is enhanced by Mg2+ and Ca2+, but is reversibly attenuated by Zn2+; KLK9 is inhibited in vitro by many naturally occurring or synthetic protease inhibitors. PMID: 28559305
    8. KLK10 potentially plays a crucial role in esophageal cancer cell growth. PMID: 26479703
    9. KLK10 may function as a tumour suppressor by repressing proliferation, enhancing apoptosis and decreasing glucose metabolism in PC3 cells. PMID: 26616394
    10. treated and untreated prolactin-producing pituitary adenomas and carcinomas as well as TSH-producing pituitary adenomas and carcinomas were conclusively immunopositive for KLK10 PMID: 25553760
    11. Immunoexpression of KLK10 in the ACTH-secreting tumors as well as in the Crooke cell tumors was significantly increased when compared with the nonfunctioning tumors and in the corticotrophs of non-tumorous pituitaries. PMID: 25517869
    12. is the first correlation of oral squamous cell carcinoma with KLK10 rs3745535G>T polymorphisms PMID: 23413953
    13. KLK10 expression is an independent biomarker of unfavorable prognosis in patients with gastric cancer. PMID: 24409072
    14. Patients with high KLK10 expression had a shorter disease-free and overall survival rates. PMID: 23499583
    15. Enhancing KLK10 gene expression can decrease the proliferation and invasiveness of human tongue cancer cells in vitro. PMID: 23268413
    16. Finding lower KLK10 levels in pleomorphic adenoma suggests aberrant expression in a tumour that develops primarily from myoepithelial cells. A kallikrein cascade may play a role in the development and/or outcome of some salivary gland tumours. PMID: 23250777
    17. KLK10 DNA methylation was significantly associated with prostate cancer. PMID: 22874102
    18. Data indicate a statistically significant positive association between kallikrein-related peptidase 10 (KLK10) and tumor stage and liver metastases. PMID: 22437349
    19. Loss of KLK10 is associated with ovarian cancer. PMID: 22102857
    20. KLK10 gene expression may be used as a marker of unfavorable prognosis for colorectal cancer PMID: 21487810
    21. Single nucleotide polymorphisms in KLK10 is not associated with ovarian cancer. PMID: 20686372
    22. Results indicate that cells underwent EMT exhibited overactive TGFbeta signaling and loss of expression of the CDH1, CGN, CLDN4, and KLK10 genes as a result of hypermethylation of their corresponding promoter regions. PMID: 20086175
    23. NES1/kallikrein 10 mRNA is expressed in normal breast tissue and benign lesions, with loss of NES1/kallikrein 10 expression during tumor progression. PMID: 11705853
    24. Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers. PMID: 11920956
    25. Higher expression in breast cancer predicts tamoxifen resistance PMID: 12087468
    26. kallikrein 10 is expressed in the nonmalignant and malignant prostate, with cancer tissues demonstrating slightly lower expression PMID: 12970725
    27. Downregulation of kallikrein 10 is associated with breast cancer PMID: 14696124
    28. Kallikrein K10 is decreased in cerebrospinal fluid (CSF) of frontotemporal dementia patients and K10 is increased in CSF of Alzheimer patients, compared to control subjects. PMID: 14972646
    29. new splice variants of the KLK10 gene identified; in silico analyses show differential expression of gene in various malignancies and provide basis for directing experimental efforts to investigate possible role of gene as cancer biomarker PMID: 16103744
    30. CpG island hypermethylation plays an important role in the downregulation of kallikrein 10 mRNA and protein expression PMID: 16254462
    31. Kallikrein 10 is highly expressed in uterine serous papillary carcinoma, and it is released in the plasma and serum of uterine serous papillary carcinoma patients. PMID: 16647913
    32. REVIEW of KLK10 gene expression in neoplasm cells PMID: 16800732
    33. functional importance of retinoic acid response elements in the hK10 promoter was demonstrated by retinoid induction of hk10 promoter-reporters PMID: 16800735
    34. results suggest a co-regulation of KLK10 and KLK11 expression in lung and a lack of KLK10 suppressor role in non-small-cell lung cancer PMID: 16800740
    35. KLK10 expression is up-regulated in CRC and GC and higher expression of KLK10 closely correlates with advanced disease stage, which predicts a poorer prognosis. PMID: 16928223
    36. Results suggest that NES1 inactivation might contribute to the malignant progression of human gastric cancers. PMID: 17182177
    37. Glucocorticoid receptor-mediated expression of kallikrein 10 PMID: 17937626
    38. The hormone-specific upregulation of PSA, KLK10 and KLK11 in the breast cancer cell line T47D is dependent on major intracellular signaling pathways. PMID: 18515984
    39. Suppression of gastric cancer growth by baculovirus vector-mediated transfer of normal epithelial cell specific-1 gene. PMID: 18855978
    40. synergistic effects between estrogens and androgens on estrogen-sensitive genes may have implications on the role of the kallikreins 10, 11, and 14 in associated risk of breast cancer and progression. PMID: 19383315
    41. Down-Regulation of KLK10 through DNA Methylation is associated with hepatocellular carcinoma. PMID: 19760608

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Peptidase S1 family, Kallikrein subfamily
  • 組織特異性:
    Expressed in breast, ovary and prostate.
  • 數據庫鏈接:

    HGNC: 6358

    OMIM: 602673

    KEGG: hsa:5655

    STRING: 9606.ENSP00000311746

    UniGene: Hs.275464



主站蜘蛛池模板: 中文字幕在线观看亚洲日韩| 夜夜高潮天天爽欧美| 无码一区二区| 东北少妇不戴套对白第一次| 欧洲亚洲国产成人综合色婷婷| 免费啪视频在线观看视频日本| 日本污ww视频网站| 亚洲精品乱码久久久久久日本 | 黑巨人与欧美精品一区| 欧美人与动人物牲交免费观看| 亚洲日韩色欲色欲com| 欧美人与动牲交a精品| 色五月丁香五月综合五月4438| 亚洲精品国产品国语原创| 久久99精品久久久久蜜芽| 亚洲国产精品无码久久98| 亚洲欧美中文日韩在线视频一| 亚洲最大激情中文字幕| 精品一二三区久久aaa片| 欧美乱色伦图片区| 日韩精品无码一区二区忘忧草| 女人19水真多免费毛片| 狠狠色狠狠色综合| 疯狂做受xxxx高潮不断 | 醉酒后少妇被疯狂内射视频| 精品国产亚洲午夜精品av| 永久免费观看国产裸体美女| 久久无码人妻丰满熟妇区毛片 | 18禁超污无遮挡无码免费网站国产 | 亚洲男男无套gv大学生| 欧美黑人又粗又大又爽免费| 无遮挡aaaaa大片免费看| 男人和女人高潮做爰视频| 国产成人精品免高潮在线观看| 国产精品久久毛片av大全日韩| 精品成人免费国产片| 偷妻之寂寞难耐2中文字幕| 老熟妇仑乱一区二区视頻| 久久www免费人成人片| av性色av久久无码ai换脸| 成 年 人 黄 色 大 片大 全|