在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KLHL3 Antibody, FITC conjugated

  • 中文名稱:
    KLHL3兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA890684HC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KLHL3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KLHL3
  • 別名:
    KLHL3 antibody; KIAA1129 antibody; Kelch-like protein 3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Kelch-like protein 3 protein (1-301AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation. The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney.
  • 基因功能參考文獻:
    1. A new recessive mutation in KLHL3 (S553L) was identified in familial hyperkalemia and hypertension. Increased urinary NCC was found in affected members (heterozygous) with dominant KLHL3 Q309R, and in affected members (homozygous) of the recessive form. PMID: 28511177
    2. Mutation in the KLHL3 gene is associated with Gordon syndrome. PMID: 28222034
    3. The results demonstrate that Hcy decreases the expression of cMyBP-C through a KLHL3-mediated ubiquitin-proteasome pathway, and thereby influences heart development. PMID: 28315668
    4. This study provides substantial new insights into the role of phosphorylation of KLHL3 in regulating the interaction with WNK4 PMID: 27727489
    5. Data indicate that WNK lysine deficient protein kinase 4 protein (WNK4) was degraded not only by proteasomes but also by atypical protein kinase C scaffold protein p62 (p62)-kelch-like 3 protein (KLHL3)-mediated selective autophagy. PMID: 26349538
    6. Familial hyperkalemia and hypertension caused by KLHL3 mutations is accompanied by hypercalciuria as well as hyperkalemia and hypertension. PMID: 25925082
    7. Akt and PKA phosphorylated KLHL3 at S433, and phosphorylation of KLHL3 by PKA inhibited WNK4 degradation. PMID: 26435498
    8. KLHL3 is phosphorylated at serine 433 in the Kelch domain (a site frequently mutated in hypertension with hyperkalemia) by protein kinase C in cultured cells and that this phosphorylation prevents WNK4 binding and degradation. PMID: 25313067
    9. Hyperkalemic hypertension-associated cul3 mutations depletes KLHL3, preventing WNK degradation, despite increased CUL3-mediated WNK ubiquitylation. PMID: 25250572
    10. CUL3 and KLHL3 gene products are physiologically important regulators of thiazide-sensitive distal nephron sodium chloride reabsorption. PMID: 24266877
    11. analysis of how mutations of KLHL3 show less ability to ubiquitinate WNK4 because of KLHL3's low stability and/or decreased binding to CUL3 or WNK4 PMID: 23962426
    12. Disease causing mutations in human KLHL3 disrupt the interaction with CUL3, a crystallographic study. PMID: 23573258
    13. KLHL3 is a substrate adaptor for WNK4 in a ubiquitin E3 ligase complex PMID: 23665031
    14. CUL3 and KLHL3 have roles in in electrolyte homeostasis and in Pseudohypoaldosteronism type II PMID: 23576762
    15. The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction. PMID: 23387299
    16. identified KLHL3 as a third gene responsible for familial hyperkalemic hypertension; study establishes a role for KLHL3 as a new member of the complex signaling pathway regulating ion homeostasis in the distal nephron and indirectly blood pressure PMID: 22406640
    17. fundamental role for KLHL3 and CUL3 in blood pressure, K(+) and pH homeostasis PMID: 22266938

    顯示更多

    收起更多

  • 相關疾病:
    Pseudohypoaldosteronism 2D (PHA2D)
  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Cytoplasm, cytosol.
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 6354

    OMIM: 605775

    KEGG: hsa:26249

    STRING: 9606.ENSP00000312397

    UniGene: Hs.655084



主站蜘蛛池模板: 在线观看的av网站| 激情内射人妻1区2区3区| 久久综合狠狠色综合伊人| 亚洲色自偷自拍另类小说| 狠狠综合亚洲综合亚洲色| 奇米777四色在线精品| 精品国产第一福利网站| 久久久久久人妻精品一区 | 精品国产一区av天美传媒| 人人模人人爽人人喊久久| 美女mm131午夜福利在线| 欧美性受xxxxzooz乱毛| 国产亚洲欧美在线专区| 国产精品自在在线午夜| 天天综合亚洲色在线精品| 亚洲精品无码成人aaa片| 国产成人综合日韩精品无码不卡| 人妻熟女一区二区aⅴ千叶宁真| 狠狠色噜噜狠狠狠狠777米奇| 亚洲成aⅴ人片久青草影院| 九九九精品成人免费视频| 亚洲hdmi高清线| 亚洲欧美国产精品专区久久| 无码av天堂一区二区三区 | 中文字幕精品亚洲无线码vr| 国产md视频一区二区三区| 内射囯产旡码丰满少妇| 成人网站免费大全日韩国产| 中文日产乱幕九区无线码| 99热久久精里都是精品6| 18禁黄网站禁片免费观看| 国产二级一片内射视频播放| 乱中年女人伦av二区 | 亚洲日韩精品a∨片无码加勒比| 婷婷五月深爱憿情网| 97热久久免费频精品99| 亚洲综合av在线在线播放| 美女张开腿黄网站免费下载| 精品成人a区在线观看| 日韩好精品视频你懂的| 欧美性猛交99久久久久99按摩|