在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KLC1 Antibody

  • 中文名稱:
    KLC1兔多克隆抗體
  • 貨號:
    CSB-PA034861
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA034861(KLC1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA034861(KLC1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Lovo cells, Primary antibody: CSB-PA034861(KLC1 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    KLC1
  • 別名:
    Kinesin 2 60/70kDa antibody; Kinesin light chain 1 antibody; Kinesin2 antibody; KLC 1 antibody; KLC antibody; Klc1 antibody; KLC1_HUMAN antibody; KNS 2 antibody; KNS 2A antibody; KNS2 antibody; KNS2A antibody; Medulloblastoma antigen MU MB 2.50 antibody; MGC15245 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human KLC1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
  • 基因功能參考文獻:
    1. structural plasticity of the N-terminal capping helix might represent a structural determinant for TPR domain structural versatility in cargo binding PMID: 29036226
    2. All binary complexes (KLC1:APP, KLC1:JIP1, and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 and JIP1 may take part in APP transport in Alzheimer's disease patients. PMID: 27891669
    3. BNIP-2 is a kinesin-1 adapter involved in vesicular transportation in the cytoplasm and that association with cargos depends on interaction of the CRAL-TRIO domain with membrane phosphatidylserine. PMID: 25472445
    4. The G allele and GG genotype of KLC1 rs8702 were significantly over-represented among cataract patients, as compared to healthy controls, and were associated with an odds ratio for cataract development. PMID: 25883527
    5. Dnm1L interacts with KLC1 through the tetratricopeptide repeat domains. PMID: 25082190
    6. Microtubule-bound kinesin-1 and kinesin-3 motor domains were visualized at multiple steps in their ATPase cycles--including their nucleotide-free states--at approximately 7 A resolution using cryo-electron microscopy. PMID: 25209998
    7. Studies indicate that FEZ1 (fasciculation and elongation protein zeta 1), SCOCO (short coiled-coil protein) and kinesins (kinesin heavy chain) are involved in biological transport process. PMID: 24116125
    8. The expression levels of KLC1 variant E in brain and lymphocytes were significantly higher in Alzheimer's disease patients. PMID: 24497505
    9. study provides evidence that the combined effect of three variants within the KLC1 gene may predispose to age-related cataract. PMID: 23776437
    10. For the binding of cargos shared by KLC1, we propose a different site located within the groove but not involving N343. PMID: 22470497
    11. Data suggest that KLC1 is required for normal neural differentiation, ensuring proper metabolism of AD-associated molecules APP and Tau and for proliferation of neural precursors (NPs). PMID: 22272245
    12. Phosphorylation of KLC1 at serine 460 modulates binding and trafficking of calsyntenin-1. PMID: 21385839
    13. Results do not convincingly support kinesin light chain 1 (KLC1) as a major susceptibility gene in any of the studied diseases, although there is a small effect of KLC1 in relation to cataract. PMID: 19911314
    14. The major binding site for kinesin light chain in kinesin heavy chain has been mapped to residues 789-813 at the C-terminal end of the heavy chain stalk domain. PMID: 12475239
    15. For a single nucleotide polymorphism (G58836C in intron 13) in the kinesin light-chain 1 (KNS2) gene, the association between Alzheimer's disease and the C allele is found to be significant. PMID: 15364413
    16. KNS2 gene may play a role during early stages of Alzheimer's disease pathogenesis. PMID: 17611642
    17. KLC1 gene may be a novel susceptibility gene for age-related cataract. PMID: 17653041
    18. microtubule-dependent functions of von Hippel-Lindau tumour suppressor are influenced by kinesin-2 PMID: 17825299
    19. The present finding supports the involvement of the cytoskeleton and KNS2 in the development of vascular white matter damage, thereby opening up novel fields in the research into leukariois. PMID: 17977659
    20. The KLC1 56836CC variant exerts a significant protective effect on the occurrence of multiple sclerosis. PMID: 17999208
    21. The rs8702 variant of the kinesin light chain 1 genotype proved to exert strong amplifying effects on the occurrence and severity of leukoaraiosis in patients with long-lasting poorly controlled severe hypertension PMID: 19046961

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell projection, growth cone. Cytoplasmic vesicle. Cytoplasm, cytoskeleton.
  • 蛋白家族:
    Kinesin light chain family
  • 組織特異性:
    Found in a variety of tissues. Mostly abundant in brain and spine.
  • 數據庫鏈接:

    HGNC: 6387

    OMIM: 600025

    KEGG: hsa:3831

    STRING: 9606.ENSP00000414982

    UniGene: Hs.20107



主站蜘蛛池模板: 女人大荫蒂毛茸茸视频| 天堂在线www资源| 99亚洲乱人伦aⅴ精品| 国产午夜精品av一区二区| 中文在线а√天堂官网| 免费人成在线观看成人片| 国产av无码专区亚洲aⅴ| 免费观看又污又黄的网站| 成品人视频ww入口| 妺妺跟我一起洗澡没忍住 | 免费不卡无码av在线观看| 超碰aⅴ人人做人人爽欧美| 天天天欲色欲色www免费| 好男人日本社区www| 亚洲精品高清国产一久久| 4399理论片午午伦夜理片| 亚洲人成网77777色在线播放| 无码高潮又爽又黄a片日本动漫| 亚洲国产日韩a在线播放| 搡女人真爽免费视频大全| aaa少妇高潮大片免费看| 极品少妇扒开粉嫩小泬视频| 亚洲精品揄拍自拍首页一 | 国产色无码精品视频国产| 国产白丝无码免费视频| 最大胆裸体人体牲交免费| 国产精品宾馆在线精品酒店| 疯狂做受xxxx高潮不断| a v 在线视频 亚洲免费| 色五月丁香六月欧美综合| 国产看真人毛片爱做a片| 成人无码免费视频在线播| 精品国产日韩亚洲一区| 亚洲精品一区二区久久| 97超碰精品成人国产| 精品熟女少妇av久久免费软件 | 亚洲色播永久网址大全| 久久国产福利国产秒拍| 亚洲va久久久噜噜噜久久4399 | 中文成人在线| 8x福利精品第一导航|