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KIR2DS3 Antibody, Biotin conjugated

  • 中文名稱:
    KIR2DS3兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA613530LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KIR2DS3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    KIR2DS3 antibody; NKAT7Killer cell immunoglobulin-like receptor 2DS3 antibody; MHC class I NK cell receptor antibody; Natural killer-associated transcript 7 antibody; NKAT-7 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Killer cell immunoglobulin-like receptor 2DS3 protein (102-241AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
  • 基因功能參考文獻:
    1. activating KIR2DS3 was associated with rapid leukocyte engraftment after hematopoietic stem cell transplantation from matched sibling PMID: 28993188
    2. Genotypes missing these two inhibitory KIR-HLA combinations in addition to missing activating KIRs 2DS2 and 2DS3 were more common in Vogt-Koyanagi-Harada disease (OR = 1.90, P = 0.002). PMID: 27490240
    3. Loss of KIR2DS3 gene is associated with breast cancer. PMID: 27631728
    4. genetic polymorphism is associated with childhood acute lymphoblastic leukemia among north Indians PMID: 26472014
    5. The genes KIR2DL5, KIR2DS3 and KIR2DS5 were present in a significantly higher proportion of individuals in the asymptomatic control group than in the malaria cases. PMID: 24929143
    6. the presence of host genetic risk factors, IL28B-T and KIR2DS3 alleles, resulted in increased odds of treatment failure in these rapid virological response negative patients. PMID: 23826153
    7. KIR2DS3 and HLA-class I alleles (-Cw*14 and -Cw*17) may play a role in the pathogenesis of the Vogt-Koyanagi-Harada disease. PMID: 22219647
    8. The Natural Killer cell gene KIR2DS3 was significantly increased in patients with chronic hepatitis C virus infection. PMID: 21402922
    9. KIR2DS3 is associated with protection against acute myeloid leukemia. PMID: 20371915
    10. Positive linkage disequilibrium was seen between KRI2DS2 and KIR2DS3. Positive linkage disequilibrium was seen between KIR3DS1 and KIR2DS3. PMID: 12559621
    11. KIR2DS3 is a protective factor for chronic graft-versus-host disease. PMID: 17462498
    12. This focuses on the inheritance of KIR2DS3*001 and *002 to clarify their genetic relationship, and will investigate the diversity of haplotypes containing a KIR2DS3 gene. PMID: 18480828
    13. Genomic and mRNA sequences support the KIR2DS3*002 gene being a hybrid of KIR2DS3*00103 and KIR2DS5. PMID: 18764809
    14. Dramatically reduced surface expression of NK cell receptor KIR2DS3 is attributed to multiple residues throughout the molecule. PMID: 19005473
    15. KIR2DS3 incompatibilities increased risk of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation PMID: 19500138

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  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Immunoglobulin superfamily
  • 數據庫鏈接:

    HGNC: 6335

    OMIM: 604954

    KEGG: hsa:3808

    UniGene: Hs.744266



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