在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. KIF4A Antibody

KIF4A Antibody

  • 中文名稱：
    KIF4A兔多克隆抗體
  • 貨號：
    CSB-PA950042
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA950042(KIF4A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA950042(KIF4A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    KIF4A
  • 別名：
    Chromokinesin antibody; Chromokinesin-A antibody; Chromosome associated kinesin KIF4A antibody; Chromosome-associated kinesin KIF4A antibody; FLJ12530 antibody; FLJ12655 antibody; FLJ14204 antibody; FLJ20631 antibody; HSA271784 antibody; KIF4 antibody; KIF4 G1 antibody; KIF4A antibody; KIF4A_HUMAN antibody; KIF4G1 antibody; Kinesin family member 4A antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human KIF4A
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis. Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization.
  • 基因功能參考文獻(xiàn)：
    1. High KIF4A expression is associated with lung cancer. PMID: 28160558
    2. decrease in Aurora B results in diminished binding of the chromokinesin Kif4A to chromosome arms. PMID: 28821562
    3. Neither KIF4A nor condensin I alone can sufficiently accumulate on the chromosomal axis and confer physiological properties to chromosomes, thus establishing that the functions of KIF4A and condensin I are inseparable PMID: 27633014
    4. Chromokinesin represents a kinesin superfamily regulating cell division through chromosome and spindle. (Review) PMID: 27196062
    5. Hepatitis B virus activates the KIF4A gene promoter and upregulates the mRNA and protein expression of KIF4A. PMID: 25998931
    6. KIF4A and PP2A-B56G and -B56E create a spatially restricted negative feedback loop counteracting Aurora B in anaphase. PMID: 25512391
    7. KIF4A might be a key regulator for tumoral progression in OSCCs. PMID: 24386490
    8. Genetic association of KIF4A and KIF5C mutations in intellectual disability and synaptic function. PMID: 24812067
    9. The KIF4A phosphorylation by Aurora B stimulates the maximal microtubule-dependent ATPase activity of KIF4A and promotes its interaction with PRC1. PMID: 23940115
    10. Studies reveal how interactions between the conserved nonmotor MAP, PRC1, and the motor protein, kinesin-4, generate filament length-dependent tags at microtubule plus ends. PRC1 tags ends of microtubules in dividing cells and the size of these tags increases linearly with filament length. PMID: 23870126
    11. KIF4 regulates midzone length during cytokinesis. PMID: 21565503
    12. Loss of KIF4 expression is associated with gastric carcinoma. PMID: 20711700
    13. Results demonstrating association of KIF4 with BRAF35 through the interaction of their respective alpha-helical coiled-coil domains is unique so far in mammals. PMID: 12809554
    14. These results suggest that KIF4 is involved in cytokinesis, although direct evidence was not provided in this study. PMID: 15031677
    15. KIF4 and its binding partner protein regulator of cytokinesis 1 play essential roles in the organization of central spindles and midzone formation PMID: 15297875
    16. Human KIF4A is an essential chromosome-associated molecular motor involved in faithful chromosome segregation. HKIF4A localizes in the nucleoplasm during interphase and on condensed chromosome arms during mitosis. PMID: 15326200
    17. role of PRC1 in midzone formation, indicate that cell cycle-dependent translocation of PRC1 by Kif4 is essential for midzone formation and cytokinesis. PMID: 15625105
    18. Zip1 and CR motifs are important for Kif4A chromatin-binding and its mitotic function. PMID: 18502200
    19. results suggest a novel role for a chromokinesin family member Kif4 in the DNA damage response by modulating the BRCA2/Rad51 pathway PMID: 18604178
    20. These studies identify a novel transit station through which Gag traffics en route to particle assembly and highlight the importance of KIF4 in regulating HIV-1 Gag trafficking and stability. PMID: 18684836

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus matrix. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Midbody. Chromosome.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Chromokinesin subfamily
  • 組織特異性：
    Highly expressed in hematopoietic tissues, fetal liver, spleen, thymus and adult thymus and bone marrow. Lower levels are found in heart, testis, kidney, colon and lung.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13339

    OMIM: 300521

    KEGG: hsa:24137

    STRING: 9606.ENSP00000363524

    UniGene: Hs.648326



主站蜘蛛池模板： 国产97色在线 | 日| 国产a国产片国产| 国产精品亚洲综合久久系列| 伊人色综合网久久天天| 99久久精品费精品国产一区二区| 亚洲 欧美日韩 综合 国产| 久久中文字幕人妻av熟女| 亚洲国产欧美在线看片一国产| 男人边吃奶边做好爽免费视频| 久久99精品久久久大学生| 人妻被按摩师玩弄到潮喷| 国产精品高潮露脸在线观看| 色综合视频一区二区三区44| 色老板精品视频在线观看| 性无码免费一区二区三区在线| 国产精品高潮呻吟av久久| 男女啪啪高清无遮挡免费| 国产卡一卡二卡三无线乱码新区| 国产内射999视频一区| 国产在线不卡人成视频| 顶级少妇做爰视频在线观看| 亚洲熟妇色自偷自拍另类| 黄在线看片免费人成视频| 国产精品麻豆aⅴ人妻| 精品无码国产污污污免费| 亚洲最大无码中文字幕| 国产美女a做受大片观看| 乱人伦中文无码视频| 特黄特色大片免费播放| 久久久综合九色综合88| 免费无码成人av在线播放不卡| 免费人成在线观看| 欲香欲色天天天综合和网| 97超碰国产精品无码分类| 中文字幕在线精品视频| 国产乱码精品一品二品| 国产精品亚洲五月天高清| 欧美丰满熟妇多毛xxxxx| 国产av国片精品| 欧美极品video粗暴| 久久国产福利播放|