在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KIF3A Antibody

  • 中文名稱:
    KIF3A兔多克隆抗體
  • 貨號:
    CSB-PA236618
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA236618(KIF3A Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA236618(KIF3A Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse brain tissue, human fetal brain tissue, human brain malignant glioma tissue, Primary antibody: CSB-PA236618(KIF3A Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    KIF 3 antibody; KIF 3A antibody; KIF3 antibody; Kif3a antibody; KIF3A_HUMAN antibody; Kifl antibody; Kinesin family member 3A antibody; Kinesin family protein 3 antibody; Kinesin family protein 3A antibody; Kinesin like protein KIF 3A antibody; Kinesin like protein KIF3A antibody; Kinesin-like protein KIF3A antibody; Kns3 antibody; Microtubule plus end directed kinesin motor 3A antibody; Microtubule plus end-directed kinesin motor 3A antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human KIF3A
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.
  • 基因功能參考文獻:
    1. KIF3A plays an important role in epithelium apoptosis and bronchial inflammation in asthma PMID: 29156524
    2. A correlation between KIF3A loss and a poorer NSCLC prognosis as well as beta-catenin and cyclin D1 upregulation further suggests that KIF3A suppresses Wnt/beta-catenin signalling and tumourigenesis in NSCLC PMID: 27596264
    3. The rate of transport is set by an equilibrium between a faster state, where only kinesin family member 17 protein (KIF17) motors move the train, and a slower state, where at least one kinesin family member 3A/B protein (KIF3AB) motor on the train remains active in transport. PMID: 28761002
    4. p0071 is required for directional vesicle movement and secretion of different KIF3-transported carriers, thereby regulating the transport of intracellular membrane vesicles along microtubules. PMID: 28808088
    5. PLCD1 acts as a tumour suppressor, by KIF3A-mediated suppression of ERK1/2/beta-catenin/MMP7 signalling, at least in part, in breast cancer. PMID: 28423710
    6. Inhibition of kif3a in the human dental follicle cells (hDFCs) and human dental pulp cells (hDPCs) is disrupted primary cilia formation and/or function, and it was shown that kif3a is important in the differentiation of hDFCs and hDPCs through the Wnt pathway. PMID: 27432616
    7. High KIF3A expression is associated with glioblastoma. PMID: 26760767
    8. These data suggest that GLI interactions with KIF3A-KIF3B-KAP3 complexes are essential for proper GLI transcriptional activity. PMID: 25588831
    9. KIF3A and OVOL1 are involved in the development of Atopic dermatitis in the Chinese pediatric population. PMID: 26127003
    10. both motor domains of KIF3A/B coordinate for processive motility and move at different speeds PMID: 15345558
    11. Ablation of this phosphorylation abolished herpes simplex virus 1 US3-mediated downregulation of CD1d expression, suggesting that phosphorylation of KIF3A is the primary mechanism of viral suppression of CD1d expression. PMID: 25878107
    12. Findings support the notion that upregulation of KIF3a is causal of aberrant activation of Wnt signaling in advanced prostate cancer through the KIF3a-DVL2-beta-catenin axis. PMID: 24413182
    13. POPX2 affects trafficking by determining the phosphorylation status of KIF3A at serine 690. PMID: 24338362
    14. Association of KIF3A, but not OVOL1 and ACTL9, with atopic eczema in Italian patients PMID: 23278845
    15. in addition to its ciliogenic roles, Kif3a recruits p150(Glued) to the subdistal appendages of mother centrioles, critical for centrosomes to function as microtubule-organizing centres. PMID: 23386061
    16. KIF3A is a novel candidate gene for childhood asthma PMID: 21912604
    17. Our findings suggest that the KIF3A gene and/or its polymorphisms might have a susceptibility effect on aspirin-intolerant asthma (AIA). PMID: 20922562
    18. Variants carried by the haplotypes of SLC22A4, SLC22A5 and KIF3A region potentially contribute to tuberculosis susceptibility among the Thai population. PMID: 20485362
    19. KIF3, cilia, and nodal flow have roles in left-right determination [review] PMID: 20066075
    20. Required for the normal steady-state localization of late endosomes/lysosomes but not early endosomes or recycling endosomes. PMID: 16262723
    21. Interaction of KIF3A/3B with KAP3 may be important for the proper progression of mitosis. PMID: 16298999
    22. We detected ALS-specific down-regulation of KIF1Bbeta and novel KIF3Abeta, two isoforms we show to be enriched in the brain, and also of SOD1, a key enzyme linked to familial ALS PMID: 17418584
    23. Rip11/FIP5-kinesin-II complex plays a key role in the routing of internalized receptors through the perinuclear recycling endosomes. PMID: 18957512
    24. Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion. PMID: 19043453
    25. This study thus reports on transportation of KSHV viral complexes on microtubules by KIF3A PMID: 19282970

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
  • 蛋白家族:
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Kinesin II subfamily
  • 數據庫鏈接:

    HGNC: 6319

    OMIM: 604683

    KEGG: hsa:11127

    STRING: 9606.ENSP00000368020

    UniGene: Hs.43670



主站蜘蛛池模板: 精品国产免费第一区二区三区| 97夜夜澡人人双人人人喊| 成年女人午夜性视频| 国产真实露脸乱子伦| 亚洲一区二区| 3d动漫精品啪啪一区二区下载| 男女吃奶做爰猛烈紧视频| 无码av片av片av无码| 手机看黄av免费网址| 亚洲性av网站| 大伊香蕉精品视频在线| 人妻少妇精品久久久久久| 久久久精品国产sm最大网站| av无码东京热亚洲男人的天堂| 午夜福利影院私人爽爽| 国模大尺度福利视频在线| 亚洲熟女乱色一区二区三区| 国产在线观看码高清视频| 亚洲人成在线观看网站不卡| 欧洲人免费视频网站在线| 久热这里只有精品12| 精品国产污污免费网站入口| 亚洲成av人在线视| 亚洲精品一区二区玖玖爱| 国产l精品国产亚洲区| 久久aⅴ人妻少妇嫩草影院| 日本人妻丰满熟妇久久久久久| 久久久一本精品99久久精品66| 男人天堂2018亚洲男人天堂| 超清无码波多野吉衣中文| 影视先锋av资源噜噜| 久久www成人_看片免费不卡| 国产熟妇另类久久久久久| 亚洲 日韩 国产欧美 另类| 第九色区av天堂| 99精品久久久久久久婷婷| 51被公侵犯玩弄漂亮人妻| 久久www免费人成看片入口| 久久国产欧美日韩精品| а√天堂8资源中文在线| 乌克兰性欧美精品高清|