在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KIF2A Antibody, Biotin conjugated

  • 中文名稱:
    KIF2A兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA012332LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KIF2A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KIF2A
  • 別名:
    CDCBM3 antibody; HK2 antibody; KIF2 antibody; KIF2A antibody; KIF2A_HUMAN antibody; Kinesin 2 antibody; Kinesin heavy chain 2 antibody; Kinesin heavy chain member 2 antibody; Kinesin heavy chain member 2A antibody; Kinesin like protein KIF2A antibody; Kinesin-2 antibody; Kinesin-like protein KIF2A antibody; KNS2 antibody; M Kinesin antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Kinesin-like protein KIF2A protein (5-308AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.
  • 基因功能參考文獻:
    1. the crystal structure of a catalytically active kinesin-13 monomer (Kif2A) in complex with two bent alphabeta-tubulin heterodimers in a head-to-tail array, providing a view of these interactions, is reported. PMID: 29980677
    2. KIF2A expression was increased in human ovarian cancer patients and in tumor tissues and KIF2A mRNA contains two target sites for miR-206 binding and confirmed that miR-206 directly suppresses KIF2A; inhibits ovarian cancer cell proliferation, migration, and invasion; and induces apoptosis. PMID: 30352438
    3. Furthermore, silencing KIF2A inhibited cell proliferation and induced apoptosis in lung adenocarcinoma(LUAD) cells. In conclusion, KIF2A may serve as a valuable prognostic indicator and promising therapeutic target of LUAD. PMID: 29427669
    4. have identified a conserved WDR5 interaction (Win) motif, so far unique to the Mixed-lineage leukemia family PMID: 28633016
    5. The effect of Kif2A Knockdown on spreading could be rescued by expression of Kif2A-GFP or FLAG-AGAP1, but not by Kif2C-GFP. The results support the hypothesis that the Kif2A.AGAP1 complex contributes to control of cytoskeleton remodeling involved in cell movement. PMID: 27531749
    6. Study used high-resolution single-molecule microscopy to directly observe the stepping behavior of kinesin-1 and -2 family motors with different length neck-linker domains. Results provide a kinetic framework for explaining kinesin processivity and for mapping structural differences to functional differences in diverse kinesin isoforms. PMID: 28636917
    7. these data provide the first evidence that increased KIF2A expression predicts poor prognosis in patients with diffuse large B cell lymphoma, and a rationale for treatment of DLBCL by targeting KIF2A. PMID: 28616658
    8. The MuvB multiprotein complex, together with B-MYB and FOXM1 (MMB-FOXM1) regulate the expression of mitotic kinesins in breast cancer cells. PMID: 28061449
    9. Mdp3 (also known as MAP7D3) forms a complex with DDA3 (also known as PSRC1) and controls spindle dynamics at the minus end of Microtubuless by inhibiting DDA3-mediated Kif2a recruitment to the spindle. PMID: 27284004
    10. High KIF2A expression is associated with Gastric Cancer. PMID: 27773961
    11. KIF2A may be important in glioma progression. PMID: 26707290
    12. This study demonstrated colorectal cancer (CRC) tissue-preferred expression pattern of the KIF2A and suggested that high KIF2A expression might serve as an independent maker for poor prognosis in CRC patients. PMID: 26070867
    13. TTBK2 phosphorylates KIF2A and antagonizes KIF2A-induced depolymerization at microtubules plus ends for cell migration. PMID: 26323690
    14. Ras regulates KIF2A to control cell migration pathways in transformed human bronchial epithelial cells. PMID: 24240690
    15. KIF2A may play an important role in breast cancer progression and is potentially a novel predictive and prognostic marker for breast cancer. PMID: 24950762
    16. up-regulation of KIF2C and KIF2A by ERK1/2 caused aberrant lysosomal positioning and mTORC1 activity in a mutant K-Ras-dependent cancer and cancer model. PMID: 25002494
    17. Silencing Kif2a induces apoptosis and decreases the mRNA and protein level of PI3K, Akt and Bcell lymphoma 2 (Bcl2) in Tca8113 cells. PMID: 24248467
    18. The distribution of Kif2A was limited to the distal ends of the central spindle through Aurora B-dependent phosphorylation and exclusion from the spindle midzone. PMID: 23960144
    19. The kinesin-2 deficiency weakened intercellular adhesion, despite the maintenance of adherens junctions and other desmosome components at the plasma membrane. PMID: 22184201
    20. Data show that 4-oxo-4-HPR inhibited tubulin polymerization and modulated gene expression of spindle aberration associated genes Kif 1C, Kif 2A, Eg5, Tara, tankyrase-1, centractin, and TOGp. PMID: 19996280
    21. Kif2a has a role in bipolar spindle assembly along with MCAK PMID: 15302853
    22. Spindles in human mitotic cells depleted of the kinesin-13 proteins Kif2a and MCAK lack detectable flux and that such cells frequently fail to segregate all chromosomes appropriately at anaphase. PMID: 16243029
    23. KIF2 gene, located at 5q12.1, is a potential schizophrenia susceptibility gene PMID: 16959419
    24. kinesin-1, but not kinesin-2, contributes to the specific cytoplasmic distribution of three of the four steps of VV morphogenesis tested. PMID: 17394562
    25. These data demonstrate that Kif2b function is required for spindle assembly and chromosome movement and that the microtubule depolymerase activities of Kif2a, Kif2b, and MCAK fulfill distinct functions during mitosis in human cells. PMID: 17538014
    26. DDA3 interacts with the MT depolymerase Kif2a in an microtubule-dependent manner and recruits Kif2a to the mitotic spindle and spindle poles. PMID: 18411309
    27. Data show that Kif2a is regulated positively by Plk1 and negatively by Aurora A, and suggest that this antagonistic regulation confers differential stability to microtubules in the spindle versus at the pole versus in the cytosol. PMID: 19351716

    顯示更多

    收起更多

  • 相關疾病:
    Cortical dysplasia, complex, with other brain malformations 3 (CDCBM3)
  • 亞細胞定位:
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Note=Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1.
  • 蛋白家族:
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, MCAK/KIF2 subfamily
  • 數據庫鏈接:

    HGNC: 6318

    OMIM: 602591

    KEGG: hsa:3796

    UniGene: Hs.558351



主站蜘蛛池模板: 亚洲无线码免费| 亚洲va在线va天堂xx xx| 免费无码av片在线观看网址| 人妻熟女一区二区aⅴ清水理纱 | 成在人线av无码免费看| 在线观看免费人成视频网| 国产97色在线 | 欧洲| 丁香啪啪综合成人亚洲| www片香蕉内射在线88av8| 成人精品动漫一区二区| 青青草免费国产线观720| 无码国产精品一区二区免费模式| 一本久道高清无码视频| 免费看女人与善牲交| 亚洲亚洲人成无码网www| 色综合伊人色综合网站无码| 久久精品国产99精品国产2021| 成人h动漫精品一区二区| 日韩精品国产另类专区| 亚洲乱妇亚洲乱妇xinglu| 免费久久99精品国产自在现线| 成人亚洲a片v一区二区三区日本| 无码中文字幕va精品影院| 97精品超碰一区二区三区| 国产熟睡乱子伦视频| 成人午夜高潮免费视频在线观看 | 国产一区丝袜在线播放| 成人免费乱码大片a毛片| 中文字幕在线播放| 亚洲欧美日韩国产成人| 亚洲中文字幕伊人久久无码| 初尝黑人嗷嗷叫中文字幕| 国产精品9999久久久久仙踪林| 人妻少妇-嫩草影院| 9lporm自拍视频区| 色偷偷色噜噜狠狠成人免费视频| 狠狠色噜噜狠狠狠狠av不卡 | 免费天堂无码人妻成人av电影| 无码国产色欲xxxx视频| 国产亚洲精品久久久美女18黄| 邪恶肉肉全彩色无遮盖|