在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KIF23 Antibody, Biotin conjugated

  • 中文名稱:
    KIF23兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA23569D0Rb
  • 規(guī)格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KIF23 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KIF23
  • 別名:
    CHO 1 antibody; CHO1 antibody; KIF 23 antibody; KIF23 antibody; KIF23_HUMAN antibody; Kinesin family member 23 antibody; Kinesin like 5 antibody; Kinesin like protein 5 antibody; Kinesin like protein KIF 23 antibody; Kinesin like protein KIF23 antibody; Kinesin-like protein 5 antibody; Kinesin-like protein KIF23 antibody; KNS L5 antibody; KNSL 5 antibody; KNSL5 antibody; Mitotic kinesin like 1 antibody; Mitotic kinesin like protein 1 antibody; Mitotic kinesin-like protein 1 antibody; MKLP 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Kinesin-like protein KIF23 protein (865-960AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.
  • 基因功能參考文獻:
    1. Data show that p120-catenin interacts with kinesin family member 23 (MKLP1) to regulate focused rhoA GTP-binding protein (RhoA) activity during cytokinesis. PMID: 28004812
    2. KIF23 was found highly expressed in NSCLC PMID: 29277180
    3. Results show the mitotic regulators KIF23 and MIS18BP1 to be co-modified by SUMO and ubiquitin on inhibition of the proteasome and subsequently identified as novel RNF4 targets. PMID: 28951443
    4. Authors found that KIF23 was regulated by TCF-4 at transcriptionally level. Therefore, this evidence indicates KIF23 over-expression is associated with glioma malignancy and conferred a worse survival time in glioma. PMID: 27013586
    5. Data show high level of KIF23 expression in the majority of primary and metastatic lung cancer tissues or cell lines and associates with poor survival. PMID: 26775597
    6. In this study we show for the first time that KIF23 V1 and V2 have different localizations in hepatocellular carcinoma cells PMID: 26674738
    7. TRAF6 mediates ubiquitination of the midbody ring localized protein KIF23/MKLP1. PMID: 24128730
    8. Transcriptional regulation of KIF23 is mediated by TP53. PMID: 23650552
    9. KIF23 mutation is associated with congenital dyserythropoietic anemia type III. PMID: 23570799
    10. It was shown that, during cytokinesis, Arf6 is first accumulated around the cleavage furrow and, prior to abscission, recruited onto the Flemming body via interaction with MKLP1. PMID: 22522702
    11. The results of this study indicated that downregulation of KIF23 decreases proliferation of glioma cells and that KIF23 may be a novel therapeutic target in malignant glioma. PMID: 21904957
    12. Study shows that 14-3-3 protein binds centralspindlin when the kinesin-6 component MKLP1 is phosphorylated at S710; 14-3-3 prevents centralspindlin from clustering in vitro, and MKLP1 mutant that is unable to bind 14-3-3 forms aberrant clusters in vivo. PMID: 20451386
    13. CHO1 and its truncated isoform MKLP1 are coexpressed in a single cell. The sequence encoded by exon 18 possesses a capability to interact with F-actin, suggesting that CHO1 can associate with both microtubule and actin cytoskeletons. PMID: 11877456
    14. Plk1 and CHO1/MKLP-1 interact to have a role in cytokinesis PMID: 15199097
    15. Recruitment of MKLP1 to the midzone/midbody by INCENP is a crucial step for the midbody formation and completion of cytokinesis in mammalian cells. PMID: 15796717
    16. Spatial restriction of Aurora B to the central spindle by MKlp2 regulates MKlp1 during cytokinesis in human cells. PMID: 16461284
    17. Cep55 directly binds to MKLP1 in vitro and associates with the MKLP1-MgcRacGAP centralspindlin complex in vivo PMID: 16790497
    18. Ectopic expression of a mutant Mklp-1 without the nuclear localization signal(s)(NLSs) leads to cell cycle arrest at cytokinesis, indicating that the NLSs are necessary for Mklp-1 to execute its normal function during cell division. PMID: 17198681
    19. study reports that mitotic complex genes Ect2, RacGAP, and MKLP1 are coordinately induced in S phase in proliferating T lymphocytes as well as in epithelial cells, depending upon activity of the CUX1 and E2F1 transcription factors PMID: 19015243
    20. MKLP1 interacts with CYK4, a GTPase activating protein for the Rho GTPase, to form the centralspindlin complex. Centralspindlin is a key regulator of Rho function and microtubule organisation during cytokinesis, and is essential for cell division. PMID: 11782313

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody, Midbody ring. Note=Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.
  • 蛋白家族:
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
  • 數據庫鏈接:

    HGNC: 6392

    OMIM: 605064

    KEGG: hsa:9493

    STRING: 9606.ENSP00000260363

    UniGene: Hs.270845



主站蜘蛛池模板: 真人抽搐一进一出gif| 欧美亚洲色欲色一欲www| 免费看成人午夜福利专区| 中国熟妇内谢69xxxxx| 亚洲国产精品毛片av不卡在线| 日日噜噜噜夜夜爽爽狠狠| 国产va免费精品高清在线| 狠狠亚洲色一日本高清色| 国产麻传媒精品国产av| 欧美成人在线视频| 在线亚洲视频网站www色| 国内精品无码一区二区三区 | 国产肥熟女视频一区二区三区 | 国产精品久久久久久亚洲影视| 国产成人av一区二区三区不卡| 137日本免费肉体摄影| 人妻夜夜爽天天爽| 青青草大香焦在线综合视频| 久久国产欧美成人网站| 久久精品国产亚洲a片高清不卡| 国产精品一久久香蕉国产线看观看| 97人人超碰国产精品最新| 爽死你欧美大白屁股在线| 国产成人精品亚洲午夜麻豆| 亚洲视频日韩视欧美视频| 一道精品视频一区二区三区| 日本肉体xxxx裸体137大胆| 一本一道av无码中文字幕﹣百度| 人妻无码手机在线中文| 日韩新无码精品毛片| 亚洲人成网77777色在线播放| 国产成人无码av一区二区| 无码中文字幕免费一区二区三区| 少妇的丰满3中文字幕| 肥臀浪妇太爽了快点再快点 | 日本特黄特色特爽大片| 国产精品无码天天爽视频| 超薄丝袜足j好爽在线观看 | 国产精品国产亚洲区艳妇糸列短篇 | 欧美35页视频在线观看| 国产精品99久久久久久人|