在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KIF20A Antibody

  • 中文名稱(chēng):
    KIF20A兔多克隆抗體
  • 貨號(hào):
    CSB-PA099632
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA099632(KIF20A Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA099632(KIF20A Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    AA415432 antibody; FLJ21151 antibody; GG10 2 antibody; GG10_2 antibody; KI20A_HUMAN antibody; KIF20A antibody; kinesin family member 20A antibody; Kinesin like protein KIF20A antibody; Kinesin-like protein 174 antibody; Kinesin-like protein KIF20A antibody; mitotic kinesin like protein 2 antibody; Mitotic kinesin-like protein 2 antibody; MKlp2 antibody; OTTHUMP00000159481 antibody; RAB6 interacting; kinesin like (rabkinesin6) antibody; Rab6-interacting kinesin-like protein antibody; RAB6-INTERACTING PROTEIN; KINESIN-LIKE antibody; RAB6KIFL antibody; Rabkinesin 6 antibody; Rabkinesin-6 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Fusion protein of Human KIF20A
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.
  • 基因功能參考文獻(xiàn):
    1. KIF20A-knockdown exhibits a suppressive effect on the cell cycle and has an inhibitory effect on the terminal cell division process (cytokinesis) leading to partial multinuclearity of the cells. PMID: 30182171
    2. In conclusion, our findings indicated that FOXM1 was highly expressed in lung cancer cells after exposure to ionizing radiation (IR). We also found that FOXM1 promoted radioresistance, invasion, migration, and EMT of lung cancer cells after IR, partly through upregulating KIF20A. PMID: 29704495
    3. Although the present study was preliminary, these data indicate the possible involvement of KIF20A in the proliferation of clearcell carcinoma (CCC), suggesting that targeting this molecule may contribute to reversing the malignant potential consequently affecting the oncologic outcome of CCC patients. PMID: 29749467
    4. Results suggest that coupling between actin and microtubule cytoskeletons driven by Myosin II and KIF20A ensures the spatial coordination between RAB6-positive vesicles fission from Golgi/trans-Golgi network membranes and their exit along microtubules. PMID: 29093437
    5. Study reveals the mechanism controlling abscission through integration of Aurora B kinase and B56-bound PP2A phosphatase activities on the kinesin motor protein MKlp2. MKlp2 is an essential protein for promoting abscission, which may regulate tethering and stabilizing of the PM to the microtubule cytoskeleton at the intercellular bridge through its previously uncharacterized lipid association motif. PMID: 27939310
    6. Identification of a novel autosomal recessive congenital restrictive cardiomyopathy, caused by a near complete loss-of-function of KIF20A. PMID: 29357359
    7. While the MKLP2 neck-linker is directed towards the microtubule plus-end in an ATP-like state, it does not fully dock along the motor domain. Furthermore, the footprint of the MKLP2 motor domain on the microtubule surface is altered compared to motile kinesins, and enhanced by kinesin-6-specific sequences. PMID: 28826477
    8. High KIF20A expression is associated with hepatocellular carcinoma. PMID: 27036048
    9. Study shows that the kinesin family member 20A (KIF20A) is a tumor-associated antigen involved in the glioma cell growth and cell survival, suggesting that KIF20A is an oncoantigen of gliomas. PMID: 28070829
    10. KIF20A is overexpressed and may serve as an independent prognostic biomarker in Nasopharyngeal Cancer. Targeting KIF20A reduces migration and invasion of Nasopharyngeal Cancer cells. PMID: 28081138
    11. elevated KIF20A expression correlates with HPV infection, clinical stage, tumor recurrence, lymphovascular space involvement, pelvic lymph node metastasis, and poor outcome in early-stage cervical squamous cell carcinoma patients. PMID: 27941992
    12. we identify KIF20A as a direct transcriptional target of FOXM1, involved in paclitaxel action and resistance PMID: 25961928
    13. Our results provide insight into the link between regulation of KIF20A-mediated trafficking of IGF2BP3-containing stress granules and modulation of the motility and invasiveness in pancreatic cancers. PMID: 25499221
    14. Kif20a expression was upregulated in pancreatic ductal adenocarcinoma and pancreatic neuroendocrine cancer compared with normal pancreas. Kif20a silencing resulted in inhibition of proliferation, motility, and invasion of pancreatic cancer cell lines. PMID: 25953216
    15. Authors propose that phosphoregulation of MKlp2 by Cdk1/cyclin B1 ensures that activation of MKlp2 kinesin and relocation of the CPC occur at the appropriate time and space for proper mitotic progression and genomic stability. PMID: 24656812
    16. targeting Aurora B to the cell cortex (or the equatorial cortex) by MKlp2 is essential for the maintenance of the ingressing furrow for successful cytokinesis PMID: 23750214
    17. Primary melanomas that were positive for KIF20A showed a significantly greater thickness than those that were negative, and patients with KIF20A+ melanoma tended to develop recurrence earlier. PMID: 22854760
    18. Used proteomics to identify the genistein-induced protein alterations in gastric cancer cells and found the silencing of KIF20A inhibited cell viability and induced G2/M arrest,& also increased cancer cell sensitivity to genistein inhibition. PMID: 22887948
    19. This gene is not involved in Charcot-Marie-Tooth disease. PMID: 12469216
    20. Collaboration of RAB6KIFL and disc large homologue 5 is likely to be involved in pancreatic cancer. PMID: 15665285
    21. Data demonstrate that Mklp2 and the chromosomal passenger complex mutually depend on each other for microtubule midzone localization, and that the association between the CPC and Mklp2 is negatively regulated by Cdk1. PMID: 19303298
    22. KIF20A (Rab6KIFL/MKlp2) is required for cytokinesis PMID: 11060022
    23. Relocation of the Aurora B/INCENP/survivin passenger protein complex requires KIF20A (MKlp2). PMID: 15263015
    24. KIF20A (MKlp2) is required for targeting of the polo like kinase 1 during anaphase and telophase cells. PMID: 12939256

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Golgi apparatus. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族:
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 9787

    OMIM: 605664

    KEGG: hsa:10112

    STRING: 9606.ENSP00000378356

    UniGene: Hs.718626



主站蜘蛛池模板: 亚洲国产精品综合久久网络| 夜夜夜夜猛噜噜噜噜噜| 国内精品久久久久久久97牛牛| 亚洲已满18点击进入在线看片| 午夜影视啪啪免费体验区入口| 天堂网www天堂资源网| 中文字幕aⅴ在线视频| 国产农村熟妇videos| 东方aⅴ免费观看久久av| 狠狠狠色丁香综合婷婷久久| 伊人久久亚洲综合影院首页| 国产成人精品亚洲日本在线观看| 免费观看性行为视频的网站| 综合色区亚洲熟妇另类| 久久精品国产自在天天线| 亚洲制服丝袜自拍中文字幕| 天天躁夜夜躁狠狠是什么心态| 好湿好紧太硬了我太爽了视频| 成在人线av无码免观看| 黑人巨大白妞出浆| 嫩草av久久伊人妇女超级a| 免费人妻精品一区二区三区| 亚洲熟妇av午夜无码不卡| 精品国产卡一卡2卡3卡| 思思久久99热只有频精品66| 国产精品嫩草影院av| 国产精品午夜福利不卡| 日本一道高清一区二区三区| 后入内射国产一区二区| 中文字幕v亚洲ⅴv天堂| 成人a片产无码免费视频在线观看| 欧美精品色婷婷五月综合| 日本最新免费二区三区| 18禁黄网站禁片免费观看不卡| 久青草国产97香蕉在线视频| 99久热在线精品996热是什么| 插我舔内射18免费视频| 久久中文字幕无码a片不卡古代| 国产高清在线精品一区二区三区 | 国产三级不卡在线观看视频| 亚洲精品专区成人网站|