在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KIF18A Antibody, HRP conjugated

  • 中文名稱:
    KIF18A兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA847753LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KIF18A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    AU024633 antibody; B130001M12Rik antibody; DKFZp434G2226 antibody; KI18A_HUMAN antibody; KIF 18A antibody; KIF18A antibody; kinesin family member 18A antibody; Kinesin like protein KIF18A antibody; Kinesin-like protein KIF18A antibody; Marrow stromal KIF18A antibody; MGC27627 antibody; MS KIF18A antibody; MS-KIF18A antibody; RGD1561740 antibody; RP23 206C1.1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Kinesin-like protein KIF18A protein (176-279AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.
  • 基因功能參考文獻:
    1. High KIF18A expression is associated with invasion and metastasis of hepatocellular carcinoma. PMID: 29466986
    2. Low post translational modifications of KIF18A protein is associated with neoplasms. PMID: 28209915
    3. KIF18a role in microtubule assembly PMID: 26912793
    4. Cdk1-mediated inhibitory phosphorylation of Kif18A promotes chromosome oscillations in early metaphase. PP1 induces metaphase plate thinning by directly dephosphorylating Kif18A. PMID: 25048371
    5. Confocal microscopy shows that cells expressing SUMO-resistant Kif18A display a compromised dissociation of BubR1 from kinetochores after anaphase onset. PMID: 25884224
    6. data support a model in which microtubule-attenuating kinesins are molecularly "tuned" to control the dynamics of specific subsets of spindle microtubules PMID: 25208566
    7. a biomarker for hepatocellular carcinoma diagnosis and an independent predictor of overall survival PMID: 25431949
    8. that the human mitotic kinesin-8, KIF18A, directly interacts with PP1gamma through a conserved RVxF motif PMID: 25281536
    9. the motion of yeast (Kip3) and human (Kif18A) kinesin-8s PMID: 23746518
    10. Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex. PMID: 23288039
    11. Kif18A (kinesin-8) attenuates centromere movement by directly promoting microtubule pausing in a concentration- dependent manner. PMID: 22595673
    12. there is a mutual regulation of kinetochore MT plus-end dynamics and Kif18A accumulation, which may contribute to the highly regulated and ordered changes in kinetochore spindle microtubule dynamics during chromosome congression and oscillation PMID: 22104080
    13. Kif18A controls spindle length independently of its role in chromosome positioning. This is mediated by an ATP-independent spindle microtubule (MT) binding site at C-terminal end of the Kif18A tail that has a strong affinity for MTs in vitro and in cells. PMID: 21885282
    14. The heightened processivity of Kif18A, conferred by its tail domain, thus promotes concentration of Kif18A at K-MT plus ends, where it suppresses their dynamics to control chromosome movements. PMID: 21884977
    15. Kif18A overexpression is associated with colorectal cancer progression. PMID: 21213216
    16. Kinesin (KIF18A) can be potentially used as a blood biomarker to identify asbestosis patients at risk of developing lung cancer. PMID: 21231887
    17. High Kif18A is associated with breast carcinogenesis. PMID: 20595236
    18. The kinesin-8 Kif18A dampens microtubule plus-end dynamics. PMID: 20153196
    19. Kif18A is a dual-functional kinesin and a key component of chromosome congression. PMID: 17346968
    20. Kif18A regulates kinetochore microtubule dynamics to control mitotic chromosome positioning. PMID: 18267093
    21. The current study sheds light on MS-KIF18A a microtubule-dependent kinesin and adds insights on the post-translational modifications that potentially control the protein cellular distribution and its co-association with cytoskeletal proteins. PMID: 18680169
    22. Studies strongly suggest that chromosome congression defects as the result of KIF18A depletion is at least in part mediated through destabilizing kinetochore CENP-E. PMID: 19625775

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell projection, ruffle. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族:
    TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
  • 數據庫鏈接:

    HGNC: 29441

    OMIM: 611271

    KEGG: hsa:81930

    STRING: 9606.ENSP00000263181

    UniGene: Hs.301052



主站蜘蛛池模板: 久久综合九色综合欧洲98| 婷婷成人丁香五月综合激情| 国精品无码一区二区三区在线蜜臀| 欧美成人精品a∨在线观看| 久久精品aⅴ无码中文字字幕不卡| 国产精品欧美成人片| 99热精品毛片全部国产无缓冲| 精品人妻系列无码人妻漫画| 国产欧美在线观看不卡| 奇米777狠狠色噜噜狠狠狠| 2021少妇久久久久久久久久| 四虎影视永久免费观看在线| 精品人伦一区二区三电影| 熟妇人妻系列aⅴ无码专区友真希| 亚欧美无遮挡hd高清在线视频| 国产精品igao视频网网址| 成人做受视频试看120秒| 亚洲欧美中文高清在线专区| 欧美精品v国产精品v日韩精品| 亚洲 中文字幕 日韩 无码| 俺也来俺也去俺也射| 狼人亚洲国内精品自在线| 国产永久免费观看的黄网站| 亚洲精品国产精品乱码不卡√| 午夜在线观看免费线无码视频| 一区二区三区在线 | 网站| 麻豆蜜桃av蜜臀av色欲av| 中文字幕人妻被公上司喝醉506 | 色婷婷久久久swag精品| 国产精品人妻久久毛片| 天堂在线最新版资源www| 亚洲肥老太bbw中国熟女| 色翁荡熄又大又硬又粗又视频图片| 国产xxxx做受性欧美88| 2021最新国产在线人成| 中文字幕在线日亚洲9| 久久精品人妻少妇一区二区三区| 97成人精品国语自产拍| 久久www成人免费直播| 中文字幕无码乱人伦| 日韩 欧美 国产 一区三|