在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. KIDINS220 Antibody

KIDINS220 Antibody

  • 中文名稱：
    KIDINS220兔多克隆抗體
  • 貨號：
    CSB-PA928650
  • 規格：
    ￥1100
  • 圖片：
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Raji cells, Hela cells, Primary antibody: CSB-PA928650(KIDINS220 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Ankyrin repeat-rich membrane-spanning protein antibody; arms antibody; KDIS_HUMAN antibody; kidins220 antibody; Kinase D interacting substance of 220 kDa antibody; Kinase D-interacting substrate of 220 kDa antibody; rgd 619949 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Rat
  • 免疫原：
    Synthetic peptide of Human KIDINS220
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.
  • 基因功能參考文獻：
    1. Kidins220 has a prominent role in tumor development by participating in a complex signaling pathways. (Review) PMID: 28849114
    2. The Kidins220 was detected in CSF from AD patients where it positively correlated with CSF phosphorylated tau and tau. PMID: 27858709
    3. Authors hence propose that the identified homozygous loss-of-function variant in KIDINS220 causes the phenotype in the presented fetuses, and that this represents a hitherto undescribed severe autosomal recessive neurodevelopmental disorder. PMID: 28934391
    4. This work reveals a crucial physiological role of KIDINS220 in development and provides insight into how perturbation of the complex interplay of KIDINS220 isoforms and their relative expression can affect neuron control and human metabolism. Altogether, we here show that de novo protein-truncating KIDINS220 variants cause a new syndrome, SINO. This is the first report of KIDINS220 variants causing a human disease. PMID: 27005418
    5. the existence of novel Kidins220/ARMS splice isoforms with unique properties PMID: 26083449
    6. Our results establish the role of ARMS in microglial activation by HIV Tat PMID: 25636783
    7. Kidins220 is expressed in neuroblastoma tumors and stabilizes NGF-induced, but not BDNF-induced, survival signaling in neuroblastoma cell lines. PMID: 23999075
    8. Kidins220 levels are increased in human brain necropsies from Alzheimer's disease patients. Kidins220 localizes within hyperphosphorylated tau aggregates, and is a substrate for GSK3beta. PMID: 23118350
    9. Kidins220 depletion is associated with the neural-to Schwann-like transition in neuroblastoma. PMID: 23333500
    10. Kidins220 is a novel T-cell receptor (TCR)-interacting protein that couples B-Raf to the TCR. Kidins220 is mandatory for sustained Erk signaling and is crucial for TCR-mediated T cell activation. PMID: 23359496
    11. Kidins220/ARMS is a functional mediator of multiple receptor signalling pathways. PMID: 22562556
    12. a novel partner of Kidins220/ARMS PMID: 22609016
    13. induction of morphological polarization in primary T lymphocytes and Jurkat cells enhances Kidins220/ARMS colocalization with ICAM-3 PMID: 21381019
    14. Ankyrin repeat-rich membrane spanning expression, conjunctly with tumour thickness or ulceration, may serve as a prognostic factor in patients with cutaneous melanoma. PMID: 21343931
    15. endogenous PKD1, PKD2, and Kidins220 co-exist with neurotensin-containing vesicles PMID: 18048355
    16. Down-regulation of ARMS results in inhibition of anchorage-independent growth in soft agar and restrictive growth of melanoma in severe combined immunodeficient mice PMID: 18089783
    17. Ankyrin-rich membrane spanning protein is a major factor that links neurotrophin signaling to nuclear factor-kappa B. PMID: 18501627
    18. sigma-1R overexpression drives sigma agonist-independent dissociation of ANK 220 from IP3R-3, resulting in activation PMID: 18539593

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Spastic paraplegia, intellectual disability, nystagmus, and obesity (SINO)
  • 亞細胞定位：
    Membrane; Multi-pass membrane protein. Late endosome. Note=Localized at late endosome before or after nerve growth factor (NGF) stimulation.
  • 組織特異性：
    Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.
  • 數據庫鏈接：

    HGNC: 29508

    OMIM: 615759

    KEGG: hsa:57498

    STRING: 9606.ENSP00000256707

    UniGene: Hs.467627



主站蜘蛛池模板： 丰满人妻被公侵犯高清版| 成 人 色综合 综合网站| 亚洲高清国产av拍精品青青草原| 成年动漫18禁无码3d动漫| 青青视频免费观看免费| 亚洲日韩国产精品无码av| 国产最大成人亚洲精品| 一本大道东京热无码| 国产精品亚洲一区二区三区在线 | 国产精品 自在自线| 女人与公拘交酡全过程| 久久久97丨国产人妻熟女| 欧美日产国产精品| 一品二品三品中文字幕| 337p西西人体大胆瓣开下部| 久久视频这里只精品| 国产女人高潮叫床免费视频| 国产黄在线观看免费观看软件| 国产午夜福利短视频| 精品人妻系列无码人妻不卡| 日本精品αv中文字幕| 天堂久久天堂av色综合| 国产精品福利一区二区久久| 日韩精品一区二区午夜成人版| 久久久久久欧美精品se一二三四 | 真实国产乱子伦精品一区二区三区| 尹人香蕉99久久综合网站| 国产成人片无码视频在线观看| а天堂中文官网| 99久久精品精品6精品精品 | 国产欧美国日产高清| 国产3p露脸普通话对白| 久久www免费人成精品| 狠人干练合综合网| 无人去码一码二码三码区| 免费拍拍拍网站| 337p粉嫩日本欧洲亚洲大胆| 秋霞av在线露丝片av无码| 久久国产高潮流白浆免费观看| 少妇高潮一区二区三区99| 人禽杂交18禁网站免费 |