在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KHSRP Antibody

  • 中文名稱:
    KHSRP兔多克隆抗體
  • 貨號:
    CSB-PA002508
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of Hela cells using FBP2 Polyclonal Antibody
    • Western Blot analysis of Jurkat cells using FBP2 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    KHSRP
  • 別名:
    Far upstream element-binding protein 2 antibody; FBP2 antibody; FUBP2 antibody; FUBP2_HUMAN antibody; FUSE binding protein 2 antibody; FUSE-binding protein 2 antibody; KH type splicing regulatory protein (FUSE binding protein 2) antibody; KH type splicing regulatory protein antibody; KH type-splicing regulatory protein antibody; KHSRP antibody; KSRP antibody; p75 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the N-terminal region of Human FBP2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
  • 基因功能參考文獻:
    1. KSRP, miR-129, and RUNX1 participate in a regulatory axis to control the outcome of myeloid differentiation. PMID: 29127290
    2. The authors find that KHSRP associates with the regulatory domain of RIG-I to maintain the receptor in an inactive state and attenuate its sensing of viral RNA (vRNA). PMID: 28248290
    3. we discovered a novel mechanism underlying SUMOylation of KHSRP regulating the production of some special miRNAs. PMID: 29020972
    4. KSRP decreased EGR3 mRNA stability in an ARE-independent manner. PMID: 28847731
    5. TGF-beta-induced KHSRP silencing is central in a pathway leading to gene-expression. PMID: 27396342
    6. mechanistic evidence that KSRP promotes the down-regulation of Spry4 by a previously unidentified mechanism, i.e. post-transcriptional mRNA regulation. PMID: 28275056
    7. The interaction between the KLHL12 and the C-terminal domain of KHSRP contributed to KHSRP ubiquitination, leading to downregulation of enterovirus internal ribosome entry sites-mediated translation in infected cells. PMID: 27899653
    8. The miRNA biogenesis factors, DDX17 and KHSRP, regulate the protein level of Ago2 in human cells. PMID: 27478153
    9. Results show that KHSRP protein is highly expressed in osteosarcoma cells and provide evidence for its important roles in regulatory controls of osteosarcoma pathogenesis. PMID: 27573585
    10. High FBP2 expression is associated with doxorubicin resistance in breast cancer . PMID: 26810065
    11. Further analyses indicated that KHSRP was involved in miR-26a maturation and inhibited the expression of PTEN in small cell lung cancer cells PMID: 27644194
    12. The expression of KSRP in liver epithelial cells controlled by mir-27b. PMID: 26631623
    13. Khsrp as a highly regulated RBP in response to genotoxic stress. PMID: 25993413
    14. The ability of KSRP to integrate different levels of gene expression is required for proper immune response. [Review] PMID: 24845017
    15. subcellular localization of KSRP is regulated by competing interactions with DDX1 or 14-3-3 PMID: 24023901
    16. KSRP induces enhanced processing of pri- and pre-miR-155 in cystic fibrosis lung epithelial cells. PMID: 23524258
    17. Enterovirus 71 infection cleaved FBP2, which altered its function when its carboxyl terminus was cleaved. PMID: 23345520
    18. Binding of the human KSRP protein to let-7 miRNA precursors positively regulates their processing to mature let-7, thereby contributing to control of cell proliferation, apoptosis and differentiation PMID: 23142982
    19. The role of KSRP in mRNA decay and microRNA precursor maturation. PMID: 21935887
    20. RACK1 binds to KH-type splicing regulatory protein (KSRP), a member of the Dicer complex, and is required for the recruitment of mature miRNAs to the RNA-induced silencing complex (RISC). PMID: 21935400
    21. KHSRP was identified as being involved in the regulation of rpL3 gene expression via alternative pre-mRNA splicing. PMID: 21705779
    22. KSRP-dependent silencing was reversed by IL-1, a strong inducer of IL-6 mRNA and protein expression. PMID: 21795706
    23. KSRP binds to the terminal loop sequence of a subset of miRNA precursors promoting their maturation (REVIEW) PMID: 21627028
    24. In this review we will discuss in detail KSRP ability to i) promote decay of labile mRNAs interacting with some components of the mRNA decay machinery and ii) favor the maturation of a select group of microRNA precursors[review] PMID: 21196264
    25. hnRNP A1 and KSRP have antagonistic roles in the post-transcriptional regulation of let-7a expression. PMID: 20639884
    26. Dishevelled-KSRP complex operates in Wnt regulation of beta-catenin, functioning post-transcriptionally upon CTNNB1 mRNA stability. PMID: 20332102
    27. KSRP do indeed interact with the c-src transcript in vivo, and that these associations change with the differentiated state of the cell. PMID: 14657238
    28. KSRP, a KH domain-containing ARE-BP, is an essential factor for ARE-directed mRNA decay. Some KH motifs of KSRP mediate RNA binding, mRNA decay, and interactions with the exosome. PMID: 15175153
    29. IL-8 RNA from IL-1beta-stimulated cytoplasmic extract revealed a 20-fold greater association of transcript with the stabilizing factor HuR vs. the destabilizing factor KSRP in breast cancer cells PMID: 15514971
    30. KHSRP, tethered to mRNAs, elicits mRNA decay. PMID: 16648466
    31. These results indicate that KSRP functions as a limiting factor in inflammatory gene expression. PMID: 17908789
    32. These data indicate a novel role for KSRP in parathyroid hormone gene expression. PMID: 18583400
    33. The over-expression of a novel protein family, far upstream binding proteins (FUBPs) was identified in both stages of hepatocellular carcinoma and confirmed by western blots. PMID: 19003864
    34. KSRP serves as a component of both Drosha and Dicer complexes and regulates the biogenesis of a subset of miRNAs PMID: 19458619
    35. The coordinated activation of FBP-1 and FBP-2 represents a novel and frequent pro-tumorigenic mechanism promoting proliferation (tumor growth) and motility (dissemination) of human liver cancer cells. PMID: 19585652
    36. Knock-down of either exosome components or KSRP by siRNAs prevents PMR1-mediated cleavage of PTH mRNA. PMID: 19775426

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    KHSRP family
  • 組織特異性:
    Detected in neural and non-neural cell lines.
  • 數據庫鏈接:

    HGNC: 6316

    OMIM: 603445

    KEGG: hsa:8570

    STRING: 9606.ENSP00000381216

    UniGene: Hs.727344



主站蜘蛛池模板: 伊伊人成亚洲综合人网| 欧美国产日本高清不卡| 99在线精品视频高潮喷吹| 国产精品区一区二区三在线播放| 亚洲另类激情综合偷自拍图| 久久超乳爆乳中文字幕| 国产l精品国产亚洲区久久| 宅男666在线永久免费观看| 久久综合久久88中字幕文| 亚洲国产精品久久精品成人网站| 亚洲综合激情七月婷婷| 裸身美女无遮挡永久免费视频| 国产大屁股喷水视频在线观看| 日本亲与子乱人妻hd| 在线综合亚洲欧美网站| 七月丁香五月婷婷首页| 久久精品无码av| 久久久久99精品成人片直播| 台湾佬中文娱乐22vvvv| 久天啪天天久久99久久| 国产成人精品免费视频大全软件| 性欧美丰满熟妇xxxx性| 国产农村熟妇videos| 久久精品国产99国产精偷| 色婷婷我要去我去也| 国产人妻精品一区二区三首| 国产普通话对白刺激| 97精品人妻一区二区三区香蕉| 欧美大屁股流白浆xxxx| 国产萌白酱喷水视频在线播放| 中文字幕无线码成人免费看| 日韩激情无码不卡码| 中文字幕乱码亚洲精品一区| 国产精品国产自线拍免费不卡| 少妇大胆瓣开下部自慰| 国产精品免费视频网站| 日韩毛片在线视频x| 又粗又紧又湿又爽的视频| 亚洲欧美日产综合在线| 大肉大捧一进一出好爽| 国产亚洲精品久久久ai换|