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  4. KERA Antibody

KERA Antibody

  • 中文名稱：
    KERA兔多克隆抗體
  • 貨號：
    CSB-PA012149ESR1HU
  • 規格：
    ￥3900
  • 圖片：
    • IHC image of CSB-PA012149ESR1HU diluted at 1:50 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) KERA Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KERA
  • 別名：
    CNA2 antibody; KERA antibody; KERA_HUMAN antibody; Keratan sulfate proteoglycan keratocan antibody; Keratocan antibody; KTN antibody; SLRR2B antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Keratocan protein (21-352AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.
  • 基因功能參考文獻：
    1. We expand the phenotypic spectrum of biallelic KERA mutations in this report of a boy with juvenile corneal ectasia who was found to harbor an underlying novel homozygous mutation in the gene. PMID: 28799822
    2. KERA mutation c.740A>G has been identified to date in three different populations, which makes it the most frequently occurring mutation in patients with cornea plana PMID: 28677912
    3. The mutation that we report here leads to the deletion of a conserved amino acid (p.Phe125del) from the third LRR motif of the keratocan protein, which might lead to an abnormal tertiary structure of the protein, thereby leading to the disease. PMID: 25967529
    4. a novel KERA variant, p.(Ile225Thr), was detected that segregates with Cornea plana in the homozygous form. PMID: 26099342
    5. Corneal endothelial disorders were found with compound mutations in KERA PMID: 23834557
    6. rare variant in KERA was identified in a large kindred with premature atherosclerosis PMID: 24879339
    7. Linkage and haplotype analyses identified 12q21.33 as a locus for posterior amorphous corneal dystrophy. However, no mutations were identified in the candidate genes (KERA, LUM, DCN, EPYC) within this region. PMID: 20357198
    8. KERA mutation is associated with autosomal recessive cornea plana PMID: 15370545
    9. This is the first report of the identification of a mutation within KERA in a family of Hispanic origin with autosomal recessive cornea plana. PMID: 16157807
    10. No evidence that endothelial dysfunction and germline mutation of lumican and keratocan genes participate in the etiology of subepithelial corneal haze. PMID: 16760896
    11. Specific for mutation in KERA, the ophthalmic phenotype of recessive cornea plana does not significantly vary with different KERA mutations. PMID: 17011957
    12. In addition, no pathogenic sequence variations were found in DCN, DSPG3, LUM, PITX2 and FOXC1, which have also been implicated in corneal and anterior segment dysgenesis. PMID: 17558846
    13. This is the first description of recessive cornea plana in a white British family and it is the second report on the p.N247S change in the KERA gene. PMID: 17679937
    14. Multiple core-protein species were detected for decorin, biglycan, lumican and keratocan in the degenerate osteoarthritic articular cartilage and menisci. PMID: 18620607

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  • 相關疾病：
    Cornea plana 2, autosomal recessive (CNA2)
  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Small leucine-rich proteoglycan (SLRP) family, SLRP class II subfamily
  • 組織特異性：
    Cornea (at protein level). Increased expression in the stroma of keratoconus corneas. Also detected in trachea, and in low levels, in intestine, skeletal muscle, ovary, lung and putamen.
  • 數據庫鏈接：

    HGNC: 6309

    OMIM: 217300

    KEGG: hsa:11081

    STRING: 9606.ENSP00000266719

    UniGene: Hs.125750



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