在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KDM4B Antibody

  • 中文名稱:
    KDM4B兔多克隆抗體
  • 貨號(hào):
    CSB-PA012138ESR1HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: KDM4B antibody at 4μg/ml
      Lane 1: Jurkat whole cell lysate
      Lane 2: k562 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 122, 51 kDa
      Observed band size: 122 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA012138ESR1HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) KDM4B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KDM4B
  • 別名:
    JHDM3B antibody; JmjC domain-containing histone demethylation protein 3B antibody; JMJD2B antibody; Jumonji domain containing 2B antibody; Jumonji domain containing protein 2B antibody; Jumonji domain-containing protein 2B antibody; Kdm4b antibody; KDM4B_HUMAN antibody; KIAA0876 antibody; Lysine (K) specific demethylase 4B antibody; Lysine demethylase 4B antibody; Lysine-specific demethylase 4B antibody; TDRD14B antibody; Tudor domain containing 14B antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Lysine-specific demethylase 4B protein (1-260AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
  • 基因功能參考文獻(xiàn):
    1. findings illustrate the significance of CREB-KDM4B-STAT3 signaling cascade in DNA damage response, and highlight that KDM4B may potentially be a novel oncotarget for colorectal cancer radiotherapy. PMID: 29633065
    2. p-ERK-mediated phosphorylation and stabilization of JMJD2B during glucose deprivation contributes to its role in glucose uptake and cell viability, which may be modulated through epigenetically upregulation of GLUT1 in colon cancer cells. PMID: 28945223
    3. KDM4B may play an important role in mitochondrial apoptosis and represent a potential therapeutic cancer target in colorectal cancer PMID: 27506941
    4. High KDM4B expression is associated with Neuroblastomas. PMID: 28684529
    5. This is the first demonstration that a Jumonji-domain histone demethylase regulates cellular processes required for peritoneal dissemination of cancer cells, one of the predominant factors affecting prognosis of EOC. The pathways regulated by KDM4B may present novel opportunities to develop combinatorial therapies to improve existing therapies for EOC patients. PMID: 27869162
    6. identification of JMJD2B/KDM4B as a p53-inducible gene in response to DNA damage. PMID: 28073943
    7. KDM4B and KDM4D expression may associate with an aggressive subtype of classical Hodgkin lymphoma and be linked with radioresistance PMID: 27630312
    8. KDM4B is a key mediator in epithelial-mesenchymal transition process, and may serve as an important prognostic marker and therapeutic target for the metastatic progression of human pancreatic cancer PMID: 26511091
    9. The overall survival (OS) of the 50 JMJD2B-positive patients after surgery was significantly inferior to that of the JMJD2B-negative patients (five-year survival=56.7% vs. 92.6%; log-rank: p=0.01). Multivariate analysis showed that JMJD2B positivity was an independent prognostic factor. CONCLUSION: JMJD2B may be a novel prognostic factor for resected lung adenocarcinoma PMID: 27630338
    10. upon TGF-beta stimulation, KDM4B was recruited to the SOX9 promoter, removed the silencing H3K9me3 marks, and activated the transcription of SOX9. PMID: 26485430
    11. High KDM4B expression is associated with endometrial cancer progression. PMID: 26397136
    12. JMJD2B and JMJD2C play an important role in the pathology of osteosarcoma via the up-regulation of FGF2. PMID: 25636512
    13. results reveal that JMJD2B is dramatically upregulated in hepatocellular carcinoma, making it a potential diagnostic marker for the further development of HCC treatment therapies PMID: 25533242
    14. Functional studies demonstrated that KDM4B regulates the Myc pathway. N-Myc was found to physically interact with and recruit KDM4B. KDM4B was found to regulate neuroblastoma cell proliferation and differentiation in vitro and xenograft growth in vivo. PMID: 25925418
    15. Data indicate that miR-491-5p plays a tumor suppressor role in the development and progression of breast cancer via direct targeting the 3'UTR of JMJD2B mRNA. PMID: 25725194
    16. Silencing of JMJD2B induces cell apoptosis via mitochondria-mediated and death receptor-mediated pathway activation in colorectal cancer. PMID: 24957706
    17. KDM4B was upregulated in colon and rectal adenocarcinomas and required for efficient growth and clonogenic activity of human HT-29 colon cancer cells. PMID: 24481461
    18. A novel function of JMJD2B in promoting epithelial-mesenchymal transition and gastric cancer invasion and metastasis. PMID: 24077348
    19. Results suggest that by regulating JMJD2b and SUV39H1 expression, p53 not only controls transcription but also promotes HC relaxation to accelerate a rate-limiting step in the repair of complex genomes. PMID: 23376847
    20. Jumonji domain-containing protein 2B has an essential role in cancer cell survival and tumor growth via DNA damage response mediation, which STAT3 partially regulates. PMID: 24473398
    21. novel pathway by which Hsp90 activity alters the histone code via regulation of KDM4B stability. PMID: 23589305
    22. JMJD2B may play a central role in gastric cancer cell growth and might constitute a novel therapeutic target to overcome hypoxia-induced radio-resistance, thereby improving the efficiency of radiation therapy. PMID: 23046878
    23. JMJD2B interacts with ERalpha and components of the SWI/SNF-B chromatin remodeling complex. JMJD2B is recruited to ERalpha target sites, demethylates H3K9me3 and facilitates transcription of ER responsive genes including MYB, MYC and CCND1. PMID: 21445275
    24. The histone demethylases KDM4B and KDM6B play critical roles in osteogenic commitment of mesenchymal stem/stromal cells. PMID: 22770241
    25. showed that JMJD2B was overexpressed in colorectal cancer tissues and positively correlated with expression of the hypoxic marker carbonic anhydrase 9 PMID: 22745382
    26. High JMJD2B is associated with bladder and lung carcinogenesis through positive regulation of cyclin-dependent kinase 6. PMID: 21930796
    27. JMJD2B is required for sustained proliferation and survival of tumor cells in vitro and in vivo, and its aberrant expression may contribute to the pathogenesis of gastric cancer. PMID: 22133676
    28. knockdown of JMJD2B severely impairs estrogen-induced cell proliferation and the tumor formation capacity of breast cancer cells PMID: 21445275
    29. Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis. PMID: 21502505
    30. Histone demethylase JMJD2B is regulated by both ERalpha and HIF-1alpha, drives breast cancer cell proliferation in normoxia and hypoxia, and epigenetically regulates the expression of cell cycle genes. PMID: 20682797
    31. Two GATA-binding sites within intron 6 of human JMJD2B gene were conserved in mouse Jmjd2b gene. PMID: 17611647
    32. Results show that many genes regulated by hypoxia and HIF-1alpha show patterns of induction with JMJD (Jumonji-domain containing)1A and JMJD2B demonstrating robust, and JMJD2C more modest, up-regulation by hypoxia. PMID: 18713068
    33. histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF PMID: 18984585

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus.
  • 蛋白家族:
    JHDM3 histone demethylase family
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 29136

    OMIM: 609765

    KEGG: hsa:23030

    STRING: 9606.ENSP00000159111

    UniGene: Hs.654816



主站蜘蛛池模板: 狠狠躁天天躁无码中文字幕| 欧洲lv尺码大精品久久久| 台湾无码一区二区| 无码av免费一区二区三区| 亚洲欧美丝袜精品久久| 免费人成视频在线| 在线天堂www在线国语对白| 人妻少妇乱子伦精品| 亚洲日韩欧洲无码av夜夜摸| 十八禁无码精品a∨在线观看| 18禁止午夜福利体验区| 熟妇的奶头又大又粗视频| 国产美女在线精品免费观看网址| 久久久久久av无码免费网站下载| 亚洲国产综合无码一区 | 国产人妻精品一区二区三区不卡 | 亚洲国产精品一区第二页| 丰满肥臀大屁股熟妇激情视频| 天天躁日日躁狠狠躁免费麻豆| 久久久www免费人成精品| 亚洲 另类 日韩 制服 无码| 久久亚洲中文无码咪咪爱| 欧美老妇乱辈通奷| 熟女少妇丰满一区二区| 女人被男人爽到呻吟的视频| 少妇无套内谢久久久久| 亚洲精品欧美综合一区二区| 久久九九精品国产免费看小说| 亚洲男人的天堂av手机在线观看 | 欧美日韩亚洲中文字幕一区二区三区 | 久久国产精品免费一区| 亚洲成_人网站图片| 天天躁日日躁狠狠躁av中文| 国产精品久久国产三级国| 亚洲2021av天堂手机版| 少妇被粗大的猛烈进出动视频| 日本在线视频www色| 久久99热人妻偷产国产| 日本三级香港三级人妇三| 婷婷五月综合国产激情| 欧美成人a在线网站|