在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KCNQ4 Antibody

  • 中文名稱:
    KCNQ4兔多克隆抗體
  • 貨號(hào):
    CSB-PA012092LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunofluorescent analysis of U251 cells using CSB-PA012092LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) KCNQ4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KCNQ4
  • 別名:
    KCNQ4; Potassium voltage-gated channel subfamily KQT member 4; KQT-like 4; Potassium channel subunit alpha KvLQT4; Voltage-gated potassium channel subunit Kv7.4
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Potassium voltage-gated channel subfamily KQT member 4 protein (401-516AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,KCNQ4 Antibody (CSB-PA012092LA01HU),的標(biāo)記方式是Non-conjugated。對(duì)于KCNQ4 Antibody,我們還提供其他標(biāo)記。見下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA012092LB01HU KCNQ4 Antibody, HRP conjugated ELISA
    FITC CSB-PA012092LC01HU KCNQ4 Antibody, FITC conjugated
    Biotin CSB-PA012092LD01HU KCNQ4 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.
  • 基因功能參考文獻(xiàn):
    1. KCNQ4 gene polymorphisms associated with susceptibility to noise-induced hearing loss. PMID: 29072670
    2. mutations in KCNQ4 gene are unlikely to be a major causative factor of ADNSHL in our studied patients from West Bengal, India, pointing to other genes might be responsible for ADNSHL in our studied patients PMID: 28802383
    3. The fundamental processes that dictate Kv7.4 activity. PMID: 27981364
    4. A novel KCNQ4 mutation, c.887 G > A (p.G296D), was identified in all five affected members in a Chinese family with autosomal dominant non-syndromic deafness 2. This mutation leads to a glycine-to-aspartic acid substitution at position 296 in the pore region of the KCNQ4 channel. PMID: 28340560
    5. Tannic acid activates Kv7.4 and Kv7.3/7.5 K(+) channels resulting in vasodilation. PMID: 26969140
    6. Gene and protein expression analyses show the predominance of KV7.4 channels over the other KV7 channel subtypes in human detrusor. PMID: 27761601
    7. Kv7.4 channels are present and functional in cardiac mitochondria; their activation exerts a significant cardioprotective role PMID: 26718475
    8. analysis of mechanistic insights into the critical roles of Ca(2+)/CaM regulation of the Kv7.4 channel under physiological and pathological conditions PMID: 26515070
    9. Interaction between G-protein betagamma subunits and Kv7.4 is crucial for channel responses to membrane voltage. PMID: 25941381
    10. genotype-phenotype correlation is analogous to that in KCNQ1 which causes autosomal dominant hereditary long QT syndrome 1 with milder phenotype and the autosomal recessive Jervell and Lange-Nielsen syndrome 1 with more severe phenotype PMID: 26036578
    11. This study provides evidence that mouse Kv7 channels may contribute differently to regulating the functional properties of cerebral and coronary arteries. PMID: 25476662
    12. The study identified a novel KCNQ4 mutation in a five generation Chinese family and a known KCNQ4 mutation in a six generation Chinese family. PMID: 25116015
    13. These findings suggest a protective role for Kv7.4 channels in the pulmonary circulation, limiting its reactivity to pressor agents and preventing hypoxia-induced pulmonary hypertension. PMID: 25361569
    14. Identified the c.211delC mutation in the KCNQ4 gene and the c.2967C>A (p.H989Q) mutation in the TECTA gene to be associated with high-frequency sensorineural hearing loss in a Japanese family. PMID: 24655070
    15. Kv7.4 currents are inhibited in a CB1 pathway repressed by endocannabinoid 2-AG PMID: 24927567
    16. In-frame deletion in KCNQ4 P-loop was identified in family members with autosomal dominant sensorineural hearing loss. PMID: 23443030
    17. Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels. PMID: 24297175
    18. decreased cell surface expression and impaired conductance of the KCNQ4 channel are two mechanisms underlying hearing loss in DFNA2 PMID: 23750663
    19. A new typical audiogram configuration characterized by mid-frequency predominant hearing loss caused by the KCNQ4 V230E mutation. PMID: 23717403
    20. The present study supports the idea that a non-truncating mutation around the N-terminus of KCNQ4 pore helix may be related to moderate hearing loss. PMID: 23399560
    21. KCNQ4 surface expression was restored by HSP90beta in cells mimicking heterozygous conditions of the DFNA2 patients. PMID: 23431407
    22. The data of this study identified a dynamic redox sensor within neuronal M-channels, which mediates reciprocal regulation of channel activity by NO and ROS PMID: 23554485
    23. Data indicate a missense mutation encoding a Tyr270His located at the N-terminus of the highly conserved of KCNQ4 pore helix sequence. PMID: 22420747
    24. no sequence alterations that segregate with autosomal dominant non-syndromic deafness in either GJB3 or KCNQ4 PMID: 21651318
    25. This work describes a gene mutation that modulates touch sensitivity in mice and humans and establishes KCNQ4 as a specific molecular marker for rapidly adapting Meissner and a subset of hair follicle afferents. PMID: 22101641
    26. Data show that KCNQ4 and KCNE1 isoforms were suppressed in placentas from term preeclamptic women. PMID: 21730298
    27. Identified is novel mutation (c.664_681del) in KCNQ4 associated with hearing loss in a Korean family with dominantly inherited deafness. PMID: 20832469
    28. mutations in the pore region, namely L274H, W276S, L281S, G285C, and G296S, as well as the C-terminal mutant G321S in the heterologous expression system, yielded non-functional channels because of endoplasmic reticulum retention of the mutant channels PMID: 20966080
    29. Autosomal dominant progressive sensorineural hearing loss due to a novel mutation in the KCNQ4 gene. PMID: 21242547
    30. evidence of the cellular etiology and mechanisms of SGN degeneration in DFNA2. PMID: 20739290
    31. The W276S mutation has occurred three times independently, and most likely represents a hot spot for mutation in the KCNQ4 gene. PMID: 12112653
    32. DFNA2 locus was found to be related to hereditary sensorineural hearing loss. PMID: 12484650
    33. KCNQ3 interacts with KCNQ4. . A chimaera (KCNQ1-sid(Q3)) carrying the si domain of KCNQ3 within the KCNQ1 backbone interacted with KCNQ4. PMID: 12524525
    34. Src associates with KCNQ2-5 subunits but phosphorylates only KCNQ3-5. PMID: 15304482
    35. KCNQ4 phosphorylation via PKA and coupling to a complex that may include prestin can lead to the negative activation and the negative resting potential found in adult outer hair cells. PMID: 15660259
    36. Polymorphisms within the KCNQ4 gene are associated with susceptibility Noise-induced hearing loss. PMID: 16823764
    37. Results shows KCNQ4 SNPs were significantly associated with Age-related hearing impairment. PMID: 16917933
    38. a novel mutation of KCNQ4 gene was identified in patients with nonsyndromic deafness. PMID: 17033161
    39. In conclusion, this work demonstrates that inactivation is a key regulatory mechanism of Kv7.4 and Kv7.5 channels. PMID: 17237198
    40. high-resolution structure of the Kv7.4 A-domain Tail together with biochemical experiments show that the domain is a self-assembling, parallel, four-stranded coiled coil PMID: 17329207
    41. G296S mutant exerts a strong dominant-negative effect on potassium currents by reducing the wild type KCNQ4 channel expression at the cell surface PMID: 18030493
    42. among the allowed assembly conformations are KCNQ3/4 and KCNQ4/5 heteromers. PMID: 18786918
    43. KCNQ4 mutations associated with progressive sensorineural hearing loss. PMID: 18797286
    44. Two novel missense mutations and a stop mutation were detected in three American families predicted to have DFNA2-related deafness; The latter is the first DFNA2-causing stop mutation reported in KCNQ4. PMID: 18941426

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Deafness, autosomal dominant, 2A (DFNA2A)
  • 亞細(xì)胞定位:
    Basal cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Potassium channel family, KQT (TC 1.A.1.15) subfamily, Kv7.4/KCNQ4 sub-subfamily
  • 組織特異性:
    Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6298

    OMIM: 600101

    KEGG: hsa:9132

    STRING: 9606.ENSP00000262916

    UniGene: Hs.473058



主站蜘蛛池模板: 天堂а在线中文在线新版| 亚洲午夜私人影院在线观看| 亚洲日韩欧美一区二区三区在线 | 午夜男女无遮挡拍拍视频| 久久国产精品人妻丝袜| 6080亚洲人久久精品| 国产日产久久高清欧美一区| 国产激情久久久久久熟女老人| 国语国产精精品国产国语清晰对话 | 97成人精品区在线播放| 亚洲精品久久久久午夜aⅴ| 香蕉视频在线精品视频| 国产女爽爽精品视频天美传媒| 黑人巨茎大战欧美白妇| 双腿高潮抽搐喷白浆视频| 图片区小说区亚洲欧美自拍| 亚洲狠狠婷婷综合久久久久图片 | 久久综合婷婷丁香五月中文字幕| 大伊香蕉精品一区视频在线| 亚洲国产成人久久一区二区三区 | 精品一区二区三区在线观看视频| 国产亚洲精品久久久久动漫| 中文字幕丰满乱子无码视频| 精品一区二区三区在线观看| 久久五月精品中文字幕| 特殊重囗味sm在线观看无码| 国产360激情盗摄全集| 柠檬福利第一导航在线| 久久99成人免费| 人妻中文字幕无码系列| 最近中文字幕mv在线视频2018| 性一交一乱一乱一视频| 欧美v亚洲v日韩v最新在线| 日本理论片午午伦夜理片2021| 免费国产黄网站在线观看可以下载 | 亚洲色欲色欲77777小说网站| 夜夜香夜夜摸夜夜添视频| 久久久久久综合网天天| 国产女人喷潮视频免费| 久久99九九精品久久久久蜜桃| 免费无码毛片一区二区app|