在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KCNQ3 Antibody, Biotin conjugated

  • 中文名稱:
    KCNQ3兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA012091LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) KCNQ3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    BFNC 2 antibody; BFNC antibody; BFNC2 antibody; EBN 2 antibody; EBN2 antibody; KCNQ 3 antibody; KCNQ3 antibody; KCNQ3_HUMAN antibody; KQT like 3 antibody; KQT-like 3 antibody; KV7.3 antibody; Potassium channel subunit alpha KvLQT3 antibody; Potassium channel voltage gated subfamily Q member 3 antibody; Potassium voltage gated channel KQT like protein 3 antibody; Potassium voltage gated channel KQT like subfamily member 3 antibody; Potassium voltage gated channel subfamily KQT member 3 antibody; Potassium voltage-gated channel subfamily KQT member 3 antibody; Voltage gated potassium channel subunit Kv7.3 antibody; Voltage-gated potassium channel subunit Kv7.3 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Potassium voltage-gated channel subfamily KQT member 3 protein (763-872AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability.
  • 基因功能參考文獻(xiàn):
    1. Phylogenetic analysis, electrostatic potential mapping, in silico docking, electrophysiology, and radioligand binding assays reveal that the anticonvulsant binding pocket evolved to accommodate endogenous neurotransmitters including gamma-aminobutyric acid, which directly activates KCNQ5 and KCNQ3 via W265. PMID: 29748663
    2. Tannic acid activates Kv7.4 and Kv7.3/7.5 K(+) channels resulting in vasodilation. PMID: 26969140
    3. Carboxyl terminus helix C-D linker residues play a role in KCNQ3 current amplitudes by controlling the exit of the KCNQ3 channel from the endoplasmic reticulum. PMID: 26692086
    4. In bipolar disorder patients' prefrontal cortex, Kcnq3 expression was decreased, DNA methylation was decreased, and Kcnq3 mRNA was decreased compared to controls. PMID: 25041603
    5. the clinical and EEG features of this patient further on expand the phenotypic variability of KCNQ3 gene mutations PMID: 25278462
    6. mutations in KCNQ3, similarly to KCNQ2, can be found in patients with more severe phenotypes including intellectual disability PMID: 25524373
    7. We monitored KCNQ2/3 channel currents and translocation of PHPLCdelta1 domains as real-time indicators of PM PI(4,5)P2, and translocation of PHOSH2x2, and PHOSH1 domains as indicators of plasma membrane and Golgi PI(4)P, respectively. PMID: 24843134
    8. This study demonistrated that benign neonatal sleep myoclonus can show autosomal dominant inheritance but not allelic to KCNQ3. PMID: 22447848
    9. KCNQ3 mutations might be involved in families with infantile seizures. PMID: 23360469
    10. Data show that KCNQ3 and KCNE5 mRNA expressions were significantly upregulated in preeclampsia. PMID: 21730298
    11. Different structural determinants, identified at the N and C termini of KCNQ3, prevent the effects of syntaxin 1A and calmodulin, respectively. PMID: 21976501
    12. This study reported that the presence of this uncommon residue at position 315 has a strong impact on the stability of the homotetramers and on channel trafficking. PMID: 20610766
    13. There may be a genetic contribution of this gene in juvenile myoclonic epilepsy in a South Indian population. PMID: 12928862
    14. Several BFNC mutations of KCNQ2 and KCNQ3 disrupt surface expression or polarized surface distribution of KCNQ channels, thereby revealing impaired targeting of KCNQ channels to axonal surfaces as a benign familial neonatal convulsions (BFNC) etiology. PMID: 16735477
    15. ICA-27243 is a novel and selective KCNQ3 potassium channel activator. PMID: 18089837
    16. The expression of KCNQ3 increased in late fetal life to infancy in brain. PMID: 18166285
    17. This study identified a novel missense mutation of KCNQ3, c.988C>T located within exon 6. c.988C>T led to the substitution Cys for Arg in amino acid position 330 (p.R330C) in KCNQ3 potassium channel. PMID: 18249525
    18. A three-dimensional homology model in the W309R mutant indicated that the R side chain of pore helices is too far from the Y side chain of the selectivity filter to interact via hydrogen bonds with each other and stabilize the pore structure. PMID: 18425618
    19. Sequence variations of the KCNQ2 (and KCNQ3)genes may contribute to the etiology of common idiopathic epilepsy syndromes. PMID: 18625963
    20. among the allowed assembly conformations are KCNQ3/4 and KCNQ4/5 heteromers. PMID: 18786918
    21. most wild-type channels are functionally silent, with rearrangements of the pore-loop architecture induced by the presence of a hydroxyl-containing residue at the 315 position "unlocking" the channels into a conductive conformation PMID: 18790849

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Seizures, benign familial neonatal 2 (BFNS2)
  • 亞細(xì)胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Potassium channel family, KQT (TC 1.A.1.15) subfamily, Kv7.3/KCNQ3 sub-subfamily
  • 組織特異性:
    Predominantly expressed in brain.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6297

    OMIM: 121201

    KEGG: hsa:3786

    STRING: 9606.ENSP00000373648

    UniGene: Hs.374023



主站蜘蛛池模板: 国产亚洲精品a在线观看下载| 国产精品久久国产精品99盘| 真实国产精品视频400部| 99国产欧美另娄久久久精品 | 乱人伦中文字幕成人网站在线| 护士脱了内裤让我爽了一夜视频 | 亚洲乱码卡一卡二卡新区仙踪木木| 樱花草视频www日本韩国| 亚洲日韩中文字幕无码一区| 久久久天堂国产精品女人| 亚洲精品国产美女久久久| 久久综合狠狠综合久久激情| 亚洲最新无码中文字幕久久| 亚洲乱码一区二三四区ava| 18禁无遮挡肉动漫在线播放观看| 熟妇五十路六十路息与子| 乱熟女高潮一区二区在线| 84pao国产成视频永久免费 | 久久久水蜜桃国产成人网站| 四虎免费最新在线永久4hu| 国产一区丝袜高跟鞋| 97人妻熟女成人免费视频色戒 | 国产精品久久久久久久9999| 精品亚洲国产成人蜜臀优播av| 99精品全国免费观看视频| 日日摸日日碰人妻无码| 国产免费丝袜调教视频| 久久精品人人槡人妻人人玩av| 欧美做受又硬又粗又大视频| 日本成aⅴ人片日本伦| 久久夜色撩人精品国产小说| 国产午夜福利小视频合集| 成年男女免费视频网站| 亚洲ⅴ国产v天堂a无码二区| 无码av不卡免费播放| 国产人成视频在线观看| 欧美v亚洲v日韩v最新在线| 中国人妻被两个老外三p| 亚洲 欧美 唯美 国产 伦 综合| 成人欧美一区二区三区黑人 | 337p日本欧洲亚洲大胆精品|